{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360023720974534144.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1113/jp284967"}},{"identifier":{"@type":"URI","@value":"https://physoc.onlinelibrary.wiley.com/doi/pdf/10.1113/JP284967"}}],"dc:title":[{"@value":"Low energy availability reduces myofibrillar and sarcoplasmic muscle protein synthesis in trained females"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec><jats:title>Abstract</jats:title><jats:p>Low energy availability (LEA) describes a state where the energy intake is insufficient to cover the energy costs of both exercise energy expenditure and basal physiological body functions. LEA has been associated with various physiological consequences, such as reproductive dysfunction. However, the effect of LEA on skeletal muscle protein synthesis in females performing exercise training is still poorly understood. We conducted a randomized controlled trial to investigate the impact of LEA on daily integrated myofibrillar and sarcoplasmic muscle protein synthesis in trained females. Thirty eumenorrheic females were matched based on training history and randomized to undergo 10 days of LEA (25 kcal · kg fat‐free mass (FFM)<jats:sup>−1</jats:sup> · day<jats:sup>−1</jats:sup>) or optimal energy availability (OEA, 50 kcal · kg FFM<jats:sup>−1</jats:sup> · day<jats:sup>−1</jats:sup>). Before the intervention, both groups underwent a 5‐day ‘run‐in’ period with OEA. All foods were provided throughout the experimental period with a protein content of 2.2 g kg lean mass<jats:sup>−1</jats:sup> · day<jats:sup>−1</jats:sup>. A standardized, supervised combined resistance and cardiovascular exercise training programme was performed over the experimental period. Daily integrated muscle protein synthesis was measured by deuterium oxide (D<jats:sub>2</jats:sub>O) consumption along with changes in body composition, resting metabolic rate, blood biomarkers and 24 h nitrogen balance. We found that LEA reduced daily integrated myofibrillar and sarcoplasmic muscle protein synthesis compared with OEA. Concomitant reductions were observed in lean mass, urinary nitrogen balance, free androgen index, thyroid hormone concentrations and resting metabolic rate following LEA. These results highlight that LEA may negatively affect skeletal muscle adaptations in females performing exercise training.\n<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mimetype=\"image/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic/tjp15634-gra-0001-m.png\"><jats:alt-text>image</jats:alt-text></jats:graphic></jats:boxed-text></jats:p></jats:sec><jats:sec><jats:title>Key points</jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Low energy availability (LEA) with potential health and performance impairments is widespread among female athletes.</jats:p></jats:list-item>\n<jats:list-item><jats:p>We investigated the impact of 10 days of LEA on daily integrated myofibrillar and sarcoplasmic muscle protein synthesis in young, trained females.</jats:p></jats:list-item>\n<jats:list-item><jats:p>We show that LEA impairs myofibrillar and sarcoplasmic muscle protein synthesis in trained females performing exercise training.</jats:p></jats:list-item>\n<jats:list-item><jats:p>These findings suggest that LEA may have negative consequences for skeletal muscle adaptations and highlight the importance of ensuring adequate energy availability in female athletes.</jats:p></jats:list-item>\n</jats:list></jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380023720974534151","@type":"Researcher","foaf:name":[{"@value":"Mikkel Oxfeldt"}],"jpcoar:affiliationName":[{"@value":"Department of Public Health Aarhus University Aarhus C Denmark"}]},{"@id":"https://cir.nii.ac.jp/crid/1380023720974534149","@type":"Researcher","foaf:name":[{"@value":"Stuart M. Phillips"}],"jpcoar:affiliationName":[{"@value":"Department of Kinesiology McMaster University Hamilton Ontario Canada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380023720974534147","@type":"Researcher","foaf:name":[{"@value":"Ole Emil Andersen"}],"jpcoar:affiliationName":[{"@value":"Department of Public Health Aarhus University Aarhus C Denmark"},{"@value":"Steno Diabetes Center Aarhus Aarhus University Aarhus Denmark"}]},{"@id":"https://cir.nii.ac.jp/crid/1380023720974534144","@type":"Researcher","foaf:name":[{"@value":"Frank Ted Johansen"}],"jpcoar:affiliationName":[{"@value":"Department of Public Health Aarhus University Aarhus C Denmark"}]},{"@id":"https://cir.nii.ac.jp/crid/1380023720974534148","@type":"Researcher","foaf:name":[{"@value":"Maj Bangshaab"}],"jpcoar:affiliationName":[{"@value":"Steno Diabetes Center Aarhus Aarhus University Aarhus Denmark"},{"@value":"Department of Clinical Medicine Aarhus University Aarhus C Denmark"}]},{"@id":"https://cir.nii.ac.jp/crid/1380023720974534152","@type":"Researcher","foaf:name":[{"@value":"Jeyanthini Risikesan"}],"jpcoar:affiliationName":[{"@value":"Department of Child and Adolescent Medicine Regional Hospital Gødstrup Gødstrup Denmark"}]},{"@id":"https://cir.nii.ac.jp/crid/1380023720974534145","@type":"Researcher","foaf:name":[{"@value":"James McKendry"}],"jpcoar:affiliationName":[{"@value":"Department of Kinesiology McMaster University Hamilton Ontario Canada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380023720974534150","@type":"Researcher","foaf:name":[{"@value":"Anna Katarina Melin"}],"jpcoar:affiliationName":[{"@value":"Department of Sport Science Linnaeus University Växjö/Kalmar Sweden"}]},{"@id":"https://cir.nii.ac.jp/crid/1380023720974534146","@type":"Researcher","foaf:name":[{"@value":"Mette Hansen"}],"jpcoar:affiliationName":[{"@value":"Department of Public Health Aarhus University Aarhus C Denmark"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00223751"},{"@type":"EISSN","@value":"14697793"}],"prism:publicationName":[{"@value":"The Journal of Physiology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2023-06-29","prism:volume":"601","prism:number":"16","prism:startingPage":"3481","prism:endingPage":"3497"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"https://physoc.onlinelibrary.wiley.com/doi/pdf/10.1113/JP284967"}],"createdAt":"2023-06-17","modifiedAt":"2023-08-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390585636769671296","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"発育期における長期間の自発走運動とカロリー制限が雌ラット骨格筋の細胞内シグナル伝達に及ぼす影響"},{"@language":"en","@value":"Effects of long-term voluntary running exercise and caloric restriction during development on intracellular signaling in female rat skeletal muscles"},{"@language":"ja-Kana","@value":"ハツイクキ ニ オケル チョウキカン ノ ジハツソウ ウンドウ ト カロリー セイゲン ガ メス ラット コッカクキン ノ サイボウ ナイ シグナル デンタツ ニ オヨボス エイキョウ"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1113/jp284967"},{"@type":"CROSSREF","@value":"10.7600/jspfsm.74.155_references_DOI_3OWTllYPcnaAbNepsjD5ZtYPgLY"}]}