{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360025435946259328.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1212/01.wnl.0000344166.03470.f8"}},{"identifier":{"@type":"URI","@value":"https://www.neurology.org/doi/pdfdirect/10.1212/01.wnl.0000344166.03470.f8"}},{"identifier":{"@type":"PMID","@value":"19273824"}}],"dc:title":[{"@value":"Apathy"}],"dcterms:alternative":[{"@value":"A major symptom in CADASIL"}],"description":[{"notation":[{"@value":"The frequency and impact of apathy in subcortical ischemic vascular dementia (SIVD) remain undetermined. The frequency, clinical, neuropsychological, and imaging correlates of apathy were assessed in a large cohort of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, a genetic model of SIVD.Apathy was diagnosed based on Neuropsychiatric Inventory assessment. Degree of disability was assessed by modified Rankin scale, cognitive impairment by Mattis Dementia Rating Scale (MDRS) and Mini-Mental State Examination (MMSE), autonomy by the Instrumental Activities of Daily Living (IADL) scale, and quality of life by SEP-59 self-questionnaire. Validated imaging methods were used to determine the total burden of cerebral lesions.Among 132 patients, 54 (41%) were apathetic. Apathetic patients were older than nonapathetic subjects, had a lower MMSE and MDRS score, had more global disability, and were more limited in IADL. Apathetic patients were more frequently depressed compared to nonapathetic patients and more frequently presented additional neuropsychiatric symptoms. Multiple regression modeling showed a significant and independent association between apathy and a lower score of overall quality of life and between apathy and a higher load of white matter and lacunar lesions.The results suggest that apathy is common in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), appears in association with cognitive impairment, global functional disability, and severe neuropsychiatric symptoms during the course of the disease, and can occur separately from depression. Apathy has an independent impact on the overall quality of life in CADASIL."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380025435946259328","@type":"Researcher","foaf:name":[{"@value":"S. Reyes"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Neurology (S.R., A.V., K.H., A.K., E.J.) and Geriatry (S.B.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, and INSERM U740 (M.G.B., H.C.), France; Department of Neurology and Clinical Trials Unit (A.V.), Massachusetts General Hospital and Harvard Medical School, Boston; INSERM U708 (O.G., C.D.), Université Pierre et Marie Curie, Paris, France; Department of Neurology (M.O.), Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany; and INSERM..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380025435946259332","@type":"Researcher","foaf:name":[{"@value":"A. Viswanathan"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Neurology (S.R., A.V., K.H., A.K., E.J.) and Geriatry (S.B.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, and INSERM U740 (M.G.B., H.C.), France; Department of Neurology and Clinical Trials Unit (A.V.), Massachusetts General Hospital and Harvard Medical School, Boston; INSERM U708 (O.G., C.D.), Université Pierre et Marie Curie, Paris, France; Department of Neurology (M.O.), Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany; and INSERM..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380025435946259333","@type":"Researcher","foaf:name":[{"@value":"O. Godin"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Neurology (S.R., A.V., K.H., A.K., E.J.) and Geriatry (S.B.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, and INSERM U740 (M.G.B., H.C.), France; Department of Neurology and Clinical Trials Unit (A.V.), Massachusetts General Hospital and Harvard Medical School, Boston; INSERM U708 (O.G., C.D.), Université Pierre et Marie Curie, Paris, France; Department of Neurology (M.O.), Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany; and INSERM..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380025435946259340","@type":"Researcher","foaf:name":[{"@value":"C. Dufouil"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Neurology (S.R., A.V., K.H., A.K., E.J.) and Geriatry (S.B.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, and INSERM U740 (M.G.B., H.C.), France; Department of Neurology and Clinical Trials Unit (A.V.), Massachusetts General Hospital and Harvard Medical School, Boston; INSERM U708 (O.G., C.D.), Université Pierre et Marie Curie, Paris, France; Department of Neurology (M.O.), Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany; and INSERM..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380025435946259336","@type":"Researcher","foaf:name":[{"@value":"S. Benisty"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Neurology (S.R., A.V., K.H., A.K., E.J.) and Geriatry (S.B.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, and INSERM U740 (M.G.B., H.C.), France; Department of Neurology and Clinical Trials Unit (A.V.), Massachusetts General Hospital and Harvard Medical School, Boston; INSERM U708 (O.G., C.D.), Université Pierre et Marie Curie, Paris, France; Department of Neurology (M.O.), Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany; and INSERM..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380025435946259329","@type":"Researcher","foaf:name":[{"@value":"K. Hernandez"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Neurology (S.R., A.V., K.H., A.K., E.J.) and Geriatry (S.B.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, and INSERM U740 (M.G.B., H.C.), France; Department of Neurology and Clinical Trials Unit (A.V.), Massachusetts General Hospital and Harvard Medical School, Boston; INSERM U708 (O.G., C.D.), Université Pierre et Marie Curie, Paris, France; Department of Neurology (M.O.), Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany; and INSERM..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380025435946259335","@type":"Researcher","foaf:name":[{"@value":"A. Kurtz"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Neurology (S.R., A.V., K.H., A.K., E.J.) and Geriatry (S.B.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, and INSERM U740 (M.G.B., H.C.), France; Department of Neurology and Clinical Trials Unit (A.V.), Massachusetts General Hospital and Harvard Medical School, Boston; INSERM U708 (O.G., C.D.), Université Pierre et Marie Curie, Paris, France; Department of Neurology (M.O.), Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany; and INSERM..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380025435946259338","@type":"Researcher","foaf:name":[{"@value":"E. Jouvent"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Neurology (S.R., A.V., K.H., A.K., E.J.) and Geriatry (S.B.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, and INSERM U740 (M.G.B., H.C.), France; Department of Neurology and Clinical Trials Unit (A.V.), Massachusetts General Hospital and Harvard Medical School, Boston; INSERM U708 (O.G., C.D.), Université Pierre et Marie Curie, Paris, France; Department of Neurology (M.O.), Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany; and INSERM..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380025435946259339","@type":"Researcher","foaf:name":[{"@value":"M. O’Sullivan"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Neurology (S.R., A.V., K.H., A.K., E.J.) and Geriatry (S.B.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, and INSERM U740 (M.G.B., H.C.), France; Department of Neurology and Clinical Trials Unit (A.V.), Massachusetts General Hospital and Harvard Medical School, Boston; INSERM U708 (O.G., C.D.), Université Pierre et Marie Curie, Paris, France; Department of Neurology (M.O.), Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany; and INSERM..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380025435946259334","@type":"Researcher","foaf:name":[{"@value":"V. Czernecki"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Neurology (S.R., A.V., K.H., A.K., E.J.) and Geriatry (S.B.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, and INSERM U740 (M.G.B., H.C.), France; Department of Neurology and Clinical Trials Unit (A.V.), Massachusetts General Hospital and Harvard Medical School, Boston; INSERM U708 (O.G., C.D.), Université Pierre et Marie Curie, Paris, France; Department of Neurology (M.O.), Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany; and INSERM..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380025435946259337","@type":"Researcher","foaf:name":[{"@value":"M. G. Bousser"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Neurology (S.R., A.V., K.H., A.K., E.J.) and Geriatry (S.B.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, and INSERM U740 (M.G.B., H.C.), France; Department of Neurology and Clinical Trials Unit (A.V.), Massachusetts General Hospital and Harvard Medical School, Boston; INSERM U708 (O.G., C.D.), Université Pierre et Marie Curie, Paris, France; Department of Neurology (M.O.), Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany; and INSERM..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380025435946259331","@type":"Researcher","foaf:name":[{"@value":"M. Dichgans"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Neurology (S.R., A.V., K.H., A.K., E.J.) and Geriatry (S.B.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, and INSERM U740 (M.G.B., H.C.), France; Department of Neurology and Clinical Trials Unit (A.V.), Massachusetts General Hospital and Harvard Medical School, Boston; INSERM U708 (O.G., C.D.), Université Pierre et Marie Curie, Paris, France; Department of Neurology (M.O.), Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany; and INSERM..."}]},{"@id":"https://cir.nii.ac.jp/crid/1380025435946259330","@type":"Researcher","foaf:name":[{"@value":"H. Chabriat"}],"jpcoar:affiliationName":[{"@value":"From the Departments of Neurology (S.R., A.V., K.H., A.K., E.J.) and Geriatry (S.B.), CHU Lariboisière, Assistance Publique des Hôpitaux de Paris, and INSERM U740 (M.G.B., H.C.), France; Department of Neurology and Clinical Trials Unit (A.V.), Massachusetts General Hospital and Harvard Medical School, Boston; INSERM U708 (O.G., C.D.), Université Pierre et Marie Curie, Paris, France; Department of Neurology (M.O.), Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany; and INSERM..."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00283878"},{"@type":"EISSN","@value":"1526632X"}],"prism:publicationName":[{"@value":"Neurology"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2009-03-10","prism:volume":"72","prism:number":"10","prism:startingPage":"905","prism:endingPage":"910"},"reviewed":"false","url":[{"@id":"https://www.neurology.org/doi/pdfdirect/10.1212/01.wnl.0000344166.03470.f8"}],"createdAt":"2009-03-09","modifiedAt":"2024-03-27","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Image%20Processing","dc:title":"Image Processing"},{"@id":"https://cir.nii.ac.jp/all?q=CADASIL","dc:title":"CADASIL"},{"@id":"https://cir.nii.ac.jp/all?q=Neuropsychological%20Tests","dc:title":"Neuropsychological Tests"},{"@id":"https://cir.nii.ac.jp/all?q=Cohort%20Studies","dc:title":"Cohort Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Computer-Assisted","dc:title":"Computer-Assisted"},{"@id":"https://cir.nii.ac.jp/all?q=Vascular","dc:title":"Vascular"},{"@id":"https://cir.nii.ac.jp/all?q=616","dc:title":"616"},{"@id":"https://cir.nii.ac.jp/all?q=Image%20Processing,%20Computer-Assisted","dc:title":"Image Processing, Computer-Assisted"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Prospective%20Studies","dc:title":"Prospective Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Psychiatric%20Status%20Rating%20Scales","dc:title":"Psychiatric Status Rating Scales"},{"@id":"https://cir.nii.ac.jp/all?q=Depression","dc:title":"Depression"},{"@id":"https://cir.nii.ac.jp/all?q=Dementia,%20Vascular","dc:title":"Dementia, Vascular"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Magnetic%20Resonance%20Imaging","dc:title":"Magnetic Resonance Imaging"},{"@id":"https://cir.nii.ac.jp/all?q=Affect","dc:title":"Affect"},{"@id":"https://cir.nii.ac.jp/all?q=Quality%20of%20Life","dc:title":"Quality of Life"},{"@id":"https://cir.nii.ac.jp/all?q=Dementia","dc:title":"Dementia"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=2728%20Clinical%20Neurology","dc:title":"2728 Clinical Neurology"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360025430657664384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Disease Severity Staging System for <i>NOTCH3</i>-Associated Small Vessel Disease, Including CADASIL"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1212/01.wnl.0000344166.03470.f8"},{"@type":"OPENAIRE","@value":"doi_dedup___::2ed50f4d673927e8eb540a308b0735af"},{"@type":"CROSSREF","@value":"10.1001/jamaneurol.2024.4487_references_DOI_45JCzmfwfpCyYd5v0TzLQSUiBtX"}]}