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This overview of the computational methods for NMR protein structure analysis presents recent automated methods for signal identification in multidimensional NMR spectra, sequence-specific resonance assignment, collection of conformational restraints, and structure calculation, as implemented in the CYANA software package. These algorithms are sufficiently reliable and integrated into one software package to enable the fully automated structure determination of proteins starting from NMR spectra without manual interventions or corrections at intermediate steps, with an accuracy of 1-2 Å backbone RMSD in comparison with manually solved reference structures."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380847868877101954","@type":"Researcher","foaf:name":[{"@value":"Julia M. Würz"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868877101955","@type":"Researcher","foaf:name":[{"@value":"Sina Kazemi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868877101952","@type":"Researcher","foaf:name":[{"@value":"Elena Schmidt"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847868877101953","@type":"Researcher","foaf:name":[{"@value":"Anurag Bagaria"}]},{"@id":"https://cir.nii.ac.jp/crid/1380283690754756864","@type":"Researcher","foaf:name":[{"@value":"Peter Güntert"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00039861"}],"prism:publicationName":[{"@value":"Archives of Biochemistry and Biophysics"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2017-08","prism:volume":"628","prism:startingPage":"24","prism:endingPage":"32"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0003986117301431?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0003986117301431?httpAccept=text/plain"}],"createdAt":"2017-03-02","modifiedAt":"2019-11-28","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Automation","dc:title":"Automation"},{"@id":"https://cir.nii.ac.jp/all?q=Statistics%20as%20Topic","dc:title":"Statistics as Topic"},{"@id":"https://cir.nii.ac.jp/all?q=Proteins","dc:title":"Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Nuclear%20Magnetic%20Resonance,%20Biomolecular","dc:title":"Nuclear Magnetic Resonance, Biomolecular"},{"@id":"https://cir.nii.ac.jp/all?q=Algorithms","dc:title":"Algorithms"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256943613696","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K07312"},{"@type":"JGN","@value":"JP17K07312"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K07312/"}],"notation":[{"@language":"ja","@value":"高分子量蛋白質のNMR構造解析を目指したスパース選択標識とNMR自動解析法の開発"},{"@language":"en","@value":"Enabling NMR studies of sparsely labelled large proteins by automated assignment"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004234670596864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Automated and assisted RNA resonance assignment using NMR chemical shift statistics"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011142938026112","@type":"Article","resourceType":"学術雑誌論文(journal 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