{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360283692468614784.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1091/mbc.e17-01-0017"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1091/mbc.E17-01-0017"}},{"identifier":{"@type":"PMID","@value":"28428259"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"RABL2 interacts with the intraflagellar transport-B complex and CEP19 and participates in ciliary assembly"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> Proteins localized to the basal body and the centrosome play crucial roles in ciliary assembly and function. Although RABL2 and CEP19 are conserved in ciliated organisms and have been implicated in ciliary/flagellar functions, their roles are poorly understood. Here we show that RABL2 interacts with CEP19 and is recruited to the mother centriole and basal body in a CEP19-dependent manner and that CEP19 is recruited to the centriole probably via its binding to the centrosomal protein FGFR1OP. Disruption of the RABL2 gene in Chlamydomonas reinhardtii results in the nonflagellated phenotype, suggesting a crucial role of RABL2 in ciliary/flagellar assembly. We also show that RABL2 interacts, in its GTP-bound state, with the intraflagellar transport (IFT)-B complex via the IFT74–IFT81 heterodimer and that the interaction is disrupted by a mutation found in male infertile mice (Mot mice) with a sperm flagella motility defect. Intriguingly, RABL2 binds to CEP19 and the IFT74–IFT81 heterodimer in a mutually exclusive manner. Furthermore, exogenous expression of the GDP-locked or Mot-type RABL2 mutant in human cells results in mild defects in ciliary assembly. These results indicate that RABL2 localized to the basal body plays crucial roles in ciliary/flagellar assembly via its interaction with the IFT-B complex. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380566395652946948","@type":"Researcher","foaf:name":[{"@value":"Yuya Nishijima"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566395652946945","@type":"Researcher","foaf:name":[{"@value":"Yohei Hagiya"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751143350656","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70778745"},{"@type":"NRID","@value":"1000070778745"},{"@type":"NRID","@value":"9000017715475"},{"@type":"NRID","@value":"9000238282468"},{"@type":"NRID","@value":"9000018807534"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/_tkubo"}],"foaf:name":[{"@value":"Tomohiro Kubo"}],"jpcoar:affiliationName":[{"@value":"University of Yamanashi Graduate School of Medical Science, Chuo 409-3898, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566395652946949","@type":"Researcher","foaf:name":[{"@value":"Ryota Takei"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, 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Nakayama"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276179787904","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90568172"},{"@type":"NRID","@value":"1000090568172"},{"@type":"ORCID","@value":"0000-0003-1649-4917"},{"@type":"NRID","@value":"9000255679742"},{"@type":"NRID","@value":"9000347361340"},{"@type":"NRID","@value":"9000390430745"},{"@type":"NRID","@value":"9000399588058"},{"@type":"NRID","@value":"9000408485835"},{"@type":"NRID","@value":"9000255959983"},{"@type":"NRID","@value":"9000397866211"},{"@type":"NRID","@value":"9000022843340"},{"@type":"NRID","@value":"9000404638713"},{"@type":"NRID","@value":"9000347362805"},{"@type":"NRID","@value":"9000255959663"},{"@type":"NRID","@value":"9000356683364"},{"@type":"NRID","@value":"9000402125265"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/ykatoh"}],"foaf:name":[{"@value":"Yohei Katoh"}],"jpcoar:affiliationName":[{"@value":"Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1380566395652946950","@type":"Researcher","foaf:name":[{"@value":"Yixian Zheng"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10591524"},{"@type":"EISSN","@value":"19394586"}],"prism:publicationName":[{"@value":"Molecular Biology of the Cell"}],"dc:publisher":[{"@value":"American Society for Cell Biology (ASCB)"}],"prism:publicationDate":"2017-06-15","prism:volume":"28","prism:number":"12","prism:startingPage":"1652","prism:endingPage":"1666"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1091/mbc.E17-01-0017"}],"createdAt":"2017-04-21","modifiedAt":"2019-07-14","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Biological%20Transport","dc:title":"Biological Transport"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Cycle%20Proteins","dc:title":"Cell Cycle Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Articles","dc:title":"Articles"},{"@id":"https://cir.nii.ac.jp/all?q=Basal%20Bodies","dc:title":"Basal Bodies"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=HEK293%20Cells","dc:title":"HEK293 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Phenotype","dc:title":"Phenotype"},{"@id":"https://cir.nii.ac.jp/all?q=Flagella","dc:title":"Flagella"},{"@id":"https://cir.nii.ac.jp/all?q=rab%20GTP-Binding%20Proteins","dc:title":"rab GTP-Binding Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Sperm%20Motility","dc:title":"Sperm Motility"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Cilia","dc:title":"Cilia"},{"@id":"https://cir.nii.ac.jp/all?q=Chlamydomonas%20reinhardtii","dc:title":"Chlamydomonas reinhardtii"},{"@id":"https://cir.nii.ac.jp/all?q=Infertility,%20Male","dc:title":"Infertility, Male"},{"@id":"https://cir.nii.ac.jp/all?q=Centrioles","dc:title":"Centrioles"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Binding","dc:title":"Protein Binding"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781830771328","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15H04370"},{"@type":"JGN","@value":"JP15H04370"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04370/"}],"notation":[{"@language":"ja","@value":"繋留複合体とSNARE複合体の連動による小胞輸送の調節"},{"@language":"en","@value":"Regulation of vesicular trafficking by tethering complex and SNARE proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781848523264","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K07929"},{"@type":"JGN","@value":"JP15K07929"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K07929/"}],"notation":[{"@language":"ja","@value":"男性不妊と肥満の原因となるRabL2-Cep19複合体の機能解析"},{"@language":"en","@value":"Functional analysis of RABL2-CEP19 complex involved in primary cilium formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000781972445824","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K15115"},{"@type":"JGN","@value":"JP17K15115"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K15115/"}],"notation":[{"@language":"ja","@value":"チューブリンポリグルタミン酸化修飾による鞭毛繊毛構築メカニズムの解明"},{"@language":"en","@value":"Elucidation of flagellar/ciliary assembly mechanism by tubulin polyglutamylation"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050012313331718528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1"}]},{"@id":"https://cir.nii.ac.jp/crid/1050013939100622464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Interactions of the dynein-2 intermediate chain WDR34 with the light chains are required for ciliary retrograde protein trafficking"}]},{"@id":"https://cir.nii.ac.jp/crid/1050016494530900096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary 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trafficking"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142814924544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Practical method for superresolution imaging of primary cilia and centrioles by expansion microscopy using an amplibody for fluorescence signal amplification"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142815553920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011142940143744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Proteome-Scale Map of the Human Interactome 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