{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360283692584897152.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/ndt/gfv221"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/ndt/article-pdf/30/8/1315/17173251/gfv221.pdf"}},{"identifier":{"@type":"PMID","@value":"26058592"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Novel lectin-independent approach to detect galactose-deficient IgA1 in IgA nephropathy"}],"description":[{"notation":[{"@value":"Galactose-deficient IgA1 (Gd-IgA1) is a critical effector molecule in the pathogenesis of IgA nephropathy (IgAN). Although many researchers have measured serum levels of Gd-IgA1 using snail helix aspersa agglutinin (HAA) lectin-based assay, the lectin-dependent assay has some serious problems in robustness. In this study, we aimed to establish a more robust and stable enzyme-linked immunosorbent assay (ELISA) method that uses a specific monoclonal antibody to recognize a hinge region in human Gd-IgA1 (Gd-IgA1 ELISA).Rats were immunized with human Gd-IgA1 hinge region peptide to obtain Gd-IgA1-specific monoclonal antibody KM55. Gd-IgA1 ELISA for specifically detecting serum Gd-IgA1 was consequently constructed. Serum Gd-IgA1 concentrations in human subjects were measured using KM55 ELISA assay. To further confirm specificity of the Gd-IgA1-specific antibody, KM55 was also applied for immunofluorescence staining of glomerular Gd-IgA1 in paraffin-embedded sections of renal biopsy specimens.Measurement of serum levels of Gd-IgA1 in human subjects by Gd-IgA1 ELISA revealed increased serum Gd-IgA1 level in patients with IgAN compared with patients with other renal diseases or non-renal diseases. Importantly, the results obtained from Gd-IgA1 ELISA positively correlated with those from the HAA lectin-based assay (R = 0.75). Immunofluorescence staining of renal biopsy specimens with KM55 detected glomerular co-localization of Gd-IgA1 and IgA.This novel lectin-independent method with KM55 for measuring serum levels of Gd-IgA1 can pave the way for more convincing diagnosis and activity assessment of IgAN, and can expedite clinical research to better understand this difficult disease."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380847870747993859","@type":"Researcher","foaf:name":[{"@value":"Junichi Yasutake"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801189441152","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70372935"},{"@type":"NRID","@value":"1000070372935"},{"@type":"NRID","@value":"9000019083452"},{"@type":"NRID","@value":"9000273016503"},{"@type":"NRID","@value":"9000256090958"},{"@type":"NRID","@value":"9000380978493"},{"@type":"NRID","@value":"9000000301149"},{"@type":"NRID","@value":"9000381455620"},{"@type":"NRID","@value":"9000020513812"},{"@type":"NRID","@value":"9000414346507"},{"@type":"NRID","@value":"9000361700398"},{"@type":"NRID","@value":"9000415088577"},{"@type":"NRID","@value":"9000343333470"},{"@type":"NRID","@value":"9000255722233"},{"@type":"NRID","@value":"9000378652447"},{"@type":"NRID","@value":"9000346931995"},{"@type":"NRID","@value":"9000356658855"},{"@type":"NRID","@value":"9000335558611"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/juntendo1227"}],"foaf:name":[{"@value":"Yusuke Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751158647808","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10468572"},{"@type":"NRID","@value":"1000010468572"},{"@type":"NRID","@value":"9000005990282"},{"@type":"NRID","@value":"9000398624487"},{"@type":"NRID","@value":"9000415088579"},{"@type":"NRID","@value":"9000402763942"},{"@type":"NRID","@value":"9000309181770"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/hyy"}],"foaf:name":[{"@value":"Hitoshi Suzuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847870747993858","@type":"Researcher","foaf:name":[{"@value":"Naoko Hiura"}]},{"@id":"https://cir.nii.ac.jp/crid/1030285133862189057","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000018563374"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/h-yanagawa"}],"foaf:name":[{"@value":"Hiroyuki Yanagawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1410282679656912131","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000019195114"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/juntendojinzo"}],"foaf:name":[{"@value":"Yuko Makita"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847870747993856","@type":"Researcher","foaf:name":[{"@value":"Etsuji Kaneko"}]},{"@id":"https://cir.nii.ac.jp/crid/1380847870747993860","@type":"Researcher","foaf:name":[{"@value":"Yasuhiko Tomino"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09310509"},{"@type":"EISSN","@value":"14602385"}],"prism:publicationName":[{"@value":"Nephrology Dialysis Transplantation"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2015-06-23","prism:volume":"30","prism:number":"8","prism:startingPage":"1315","prism:endingPage":"1321"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"http://academic.oup.com/ndt/article-pdf/30/8/1315/17173251/gfv221.pdf"}],"createdAt":"2015-06-25","modifiedAt":"2018-04-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Kidney%20Glomerulus","dc:title":"Kidney Glomerulus"},{"@id":"https://cir.nii.ac.jp/all?q=Antibodies,%20Monoclonal","dc:title":"Antibodies, Monoclonal"},{"@id":"https://cir.nii.ac.jp/all?q=Fluorescent%20Antibody%20Technique","dc:title":"Fluorescent Antibody Technique"},{"@id":"https://cir.nii.ac.jp/all?q=Galactose","dc:title":"Galactose"},{"@id":"https://cir.nii.ac.jp/all?q=Enzyme-Linked%20Immunosorbent%20Assay","dc:title":"Enzyme-Linked Immunosorbent Assay"},{"@id":"https://cir.nii.ac.jp/all?q=Glomerulonephritis,%20IGA","dc:title":"Glomerulonephritis, IGA"},{"@id":"https://cir.nii.ac.jp/all?q=CLINICAL%20SCIENCE","dc:title":"CLINICAL SCIENCE"},{"@id":"https://cir.nii.ac.jp/all?q=Immunoglobulin%20A","dc:title":"Immunoglobulin A"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Sprague-Dawley","dc:title":"Rats, Sprague-Dawley"},{"@id":"https://cir.nii.ac.jp/all?q=Agglutinins","dc:title":"Agglutinins"},{"@id":"https://cir.nii.ac.jp/all?q=Lectins","dc:title":"Lectins"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers","dc:title":"Biomarkers"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781850743424","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K09274"},{"@type":"JGN","@value":"JP15K09274"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09274/"}],"notation":[{"@language":"ja","@value":"IgA腎症の病態におけるTLR/BAFF/APRILの役割の解明"},{"@language":"en","@value":"Role of TLR/BAFF/APRIL in the pathogenesis of IgA nephropathy"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050294045368759936","@type":"Article","resourceType":"学術雑誌論文(journal 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