{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360283693197838720.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1440-1789.2011.01287.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1440-1789.2011.01287.x"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1440-1789.2011.01287.x"}},{"identifier":{"@type":"PMID","@value":"22239237"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Bisphenol A, an endocrine‐disrupting chemical, and brain development"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Bisphenol A (BPA) is an endocrine‐disrupting chemical, widely used in various industries and the field of dentistry. The consequent increase in BPA exposure among humans has led us to some concerns regarding the potential deleterious effects on reproduction and brain development. The emphasis of this review is on the effects of prenatal and lactational exposure to low doses of BPA on brain development in mice. We demonstrated that prenatal exposure to BPA affected fetal murine neocortical development by accelerating neuronal differentiation/migration during the early embryonic stage, which was associated with up‐ and down‐regulation of the genes critical for brain development, including the basic helix‐loop‐helix transcription factors. In the adult mice brains, both abnormal neocortical architecture and abnormal corticothalamic projections persisted in the group exposed to the BPA. Functionally, BPA exposure disturbed murine behavior, accompanied with a disrupted neurotransmitter system, including monoamines, in the postnatal development period and in adult mice. We also demonstrated that epigenetic alterations in promoter‐associated CpG islands might underlie some of the effects on brain development after exposure to BPA.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420564276178127616","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80243301"},{"@type":"NRID","@value":"1000080243301"},{"@type":"NRID","@value":"9000010226577"},{"@type":"NRID","@value":"9000006564366"},{"@type":"NRID","@value":"9000402387274"},{"@type":"NRID","@value":"9000409208125"},{"@type":"NRID","@value":"9000002230145"},{"@type":"NRID","@value":"9000001530400"},{"@type":"NRID","@value":"9000283731569"},{"@type":"NRID","@value":"9000309183008"},{"@type":"NRID","@value":"9000255722748"},{"@type":"NRID","@value":"9000239584073"},{"@type":"NRID","@value":"9000401961664"},{"@type":"NRID","@value":"9000003167156"},{"@type":"NRID","@value":"9000023879899"},{"@type":"NRID","@value":"9000347048855"},{"@type":"NRID","@value":"9000003166827"},{"@type":"NRID","@value":"9000020927806"},{"@type":"NRID","@value":"9000016269637"},{"@type":"NRID","@value":"9000107311252"},{"@type":"NRID","@value":"9000022071303"},{"@type":"NRID","@value":"9000402436493"},{"@type":"NRID","@value":"9000021384561"},{"@type":"NRID","@value":"9000345273336"},{"@type":"NRID","@value":"9000005933239"},{"@type":"NRID","@value":"9000020928247"},{"@type":"NRID","@value":"9000021366179"},{"@type":"NRID","@value":"9000402942206"},{"@type":"NRID","@value":"9000414095567"},{"@type":"NRID","@value":"9000244899329"},{"@type":"NRID","@value":"9000391978042"},{"@type":"NRID","@value":"9000325466670"},{"@type":"NRID","@value":"9000015205985"},{"@type":"NRID","@value":"9000381066945"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/kxi14"}],"foaf:name":[{"@value":"Kyoko Itoh"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284921423221378","@type":"Researcher","foaf:name":[{"@value":"Takeshi Yaoi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284921423221376","@type":"Researcher","foaf:name":[{"@value":"Shinji Fushiki"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09196544"},{"@type":"EISSN","@value":"14401789"}],"prism:publicationName":[{"@value":"Neuropathology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2012-01-12","prism:volume":"32","prism:number":"4","prism:startingPage":"447","prism:endingPage":"457"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1440-1789.2011.01287.x"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1440-1789.2011.01287.x"}],"createdAt":"2012-01-13","modifiedAt":"2023-10-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Phenols","dc:title":"Phenols"},{"@id":"https://cir.nii.ac.jp/all?q=Neurogenesis","dc:title":"Neurogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Brain","dc:title":"Brain"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Benzhydryl%20Compounds","dc:title":"Benzhydryl Compounds"},{"@id":"https://cir.nii.ac.jp/all?q=Endocrine%20Disruptors","dc:title":"Endocrine Disruptors"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782032408192","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20310036"},{"@type":"JGN","@value":"JP20310036"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20310036/"}],"notation":[{"@language":"ja","@value":"エピジェネティックスと神経細胞移動に注目したビスフェノールA胎生期曝露の影響解析"},{"@language":"en","@value":"Studies on the effects of prenatal exposure to bisphenol A in mouse brain, with special reference to neuronal migration and epigenetic alteratio ns"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782067912448","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21300324"},{"@type":"JGN","@value":"JP21300324"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21300324/"}],"notation":[{"@language":"ja","@value":"臨床医工学をめぐるコミュニケーション・モデルの構築に向けて"},{"@language":"en","@value":"Toward the establishment of communication model on medical engineering"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782076668544","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21510072"},{"@type":"JGN","@value":"JP21510072"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21510072/"}],"notation":[{"@language":"ja","@value":"神経細胞分化のモデル培養系へのビスフェノールA曝露とエピジェネティック変異"},{"@language":"en","@value":"Changes of Transcriptome and DNA methylation in P19 neurons exposed to Bisphenol A"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050568772226740608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of maternal bisphenol A diglycidyl ether exposure during gestation and lactation on behavior and brain development of the 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