{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360283693315729664.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/joa.12707"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjoa.12707"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/joa.12707"}},{"identifier":{"@type":"PMID","@value":"29023691"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Anatomy and development of the extrahepatic biliary system in mouse and rat: a perspective on the evolutionary loss of the gallbladder"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The gallbladder is the hepatobiliary organ for storing and secreting bile fluid, and is a synapomorphy of extant vertebrates. However, this organ has been frequently lost in several lineages of birds and mammals, including rodents. Although it is known as the traditional problem, the differences in development between animals with and without gallbladders are not well understood. To address this research gap, we compared the anatomy and development of the hepatobiliary systems in mice (gallbladder is present) and rats (gallbladder is absent). Anatomically, almost all parts of the hepatobiliary system of rats are topographically the same as those of mice, but rats have lost the gallbladder and cystic duct completely. During morphogenesis, the gallbladder–cystic duct domain (Gb–Cd domain) and its primordium, the biliary bud, do not develop in the rat. In the early stages, <jats:styled-content style=\"fixed-case\">SOX</jats:styled-content>17, a master regulator of gallbladder formation, is positive in the murine biliary bud epithelium, as seen in other vertebrates with a gallbladder, but there is no <jats:styled-content style=\"fixed-case\">SOX</jats:styled-content>17‐positive domain in the rat hepatobiliary primordia. These findings suggest that the evolutionary loss of the Gb–Cd domain should be translated simply as the absence of a biliary bud at an early stage, which may correlate with alterations in regulatory genes, such as <jats:italic>Sox17</jats:italic>, in the rat. A <jats:styled-content style=\"fixed-case\">SOX</jats:styled-content>17‐positive biliary bud is clearly definable as a developmental module that may be involved in the frequent loss of gallbladder in mammals.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380283693315729664","@type":"Researcher","foaf:name":[{"@value":"Hiroki Higashiyama"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Veterinary Anatomy The University of Tokyo Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284921545753988","@type":"Researcher","foaf:name":[{"@value":"Mami Uemura"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Veterinary Anatomy The University of Tokyo Tokyo Japan"},{"@value":"Center for Experimental Animals Tokyo Medical and Dental University Bunkyo‐ku Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284921545753985","@type":"Researcher","foaf:name":[{"@value":"Hitomi Igarashi"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Veterinary Anatomy The University of Tokyo Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380284921545753984","@type":"Researcher","foaf:name":[{"@value":"Masamichi Kurohmaru"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Veterinary Anatomy The University of Tokyo Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579814296313600","@type":"Researcher","foaf:name":[{"@value":"Masami Kanai‐Azuma"}],"jpcoar:affiliationName":[{"@value":"Center for Experimental Animals Tokyo Medical and Dental University Bunkyo‐ku Tokyo Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751138209792","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30260326"},{"@type":"NRID","@value":"1000030260326"},{"@type":"NRID","@value":"9000000810924"},{"@type":"NRID","@value":"9000253282317"},{"@type":"NRID","@value":"9000009971527"},{"@type":"NRID","@value":"9000415337645"},{"@type":"NRID","@value":"9000415338236"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0123258"}],"foaf:name":[{"@value":"Yoshiakira Kanai"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Veterinary Anatomy The University of Tokyo Tokyo Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00218782"},{"@type":"EISSN","@value":"14697580"}],"prism:publicationName":[{"@value":"Journal of Anatomy"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2017-10-10","prism:volume":"232","prism:number":"1","prism:startingPage":"134","prism:endingPage":"145"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjoa.12707"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/joa.12707"}],"createdAt":"2017-10-11","modifiedAt":"2023-09-29","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Sprague-Dawley","dc:title":"Rats, Sprague-Dawley"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Bile%20Ducts,%20Extrahepatic","dc:title":"Bile Ducts, Extrahepatic"},{"@id":"https://cir.nii.ac.jp/all?q=Morphogenesis","dc:title":"Morphogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Gallbladder","dc:title":"Gallbladder"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781906069248","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16J40235"},{"@type":"JGN","@value":"JP16J40235"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16J40235/"}],"notation":[{"@language":"ja","@value":"胆嚢／胆管系発生におけるＳｏｘ１７を中心とした分子ネットワークの解明"}]},{"@id":"https://cir.nii.ac.jp/crid/1040000782191965056","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24228005"},{"@type":"JGN","@value":"JP24228005"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24228005/"}],"notation":[{"@language":"ja","@value":"胆嚢・胆管の形態形成・再生能と先天性疾患の分子機構の解明"},{"@language":"en","@value":"Morphogenesis, regeneration and congenital disease in gallbladder and bile duct system in mammals"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360283690829237376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interspecies Chimerism with Mammalian Pluripotent Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690834105088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Whole-body and Whole-Organ Clearing and Imaging Techniques with Single-Cell Resolution: Toward Organism-Level Systems Biology in Mammals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706976672640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618525378560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Germ layer patterning in bichir and lamprey; an insight into its evolution in vertebrates"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618855870976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bile salts of vertebrates: structural variation and possible evolutionary significance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620038944128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Shape of Life"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620800242304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Loss and Re-emergence of Legs in Snakes by Modular Evolution of Sonic hedgehog and HOXD Enhancers"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757426242560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Gross anatomy of the Pacific hagfish,\n                    <i>Eptatretus burgeri</i>\n                    , with special reference to the coelomic viscera"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565164386297600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anatomy of the Murine Hepatobiliary System: A Whole‐Organ‐Level Analysis Using a Transparency Method"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165805689216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Generation of Rat Pancreas in Mouse by Interspecific Blastocyst Injection of Pluripotent Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169045028992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Sox17</i> haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186931799936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Embryonic cholecystitis and defective gallbladder contraction in the <i>Sox17</i>-haploinsufficient mouse model of biliary atresia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094976385792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095565493376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adaptive Evolution of Eye Degeneration in the Mexican Blind Cavefish"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095818772992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The extrahepatic biliary tract in the guinea‐pig"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096166980736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evolution in Reverse Gear: The Molecular Basis of Loss and Reversal"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232428123776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"pH-taxis drives aerobic bacteria in duodenum to migrate into the pancreas with tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588380588400896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of gallbladder hypoplasia on hilar hepatic ducts in biliary atresia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569993739648","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biliary tree stem/progenitor cells in glands of extrahepatic and intraheptic bile ducts: an anatomical <i>in situ</i> study yielding evidence of maturational lineages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360862100452108032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Congenital Absence of the Gallbladder and Cystic Duct*"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045368807552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Presence or absence of gall bladder in some Akodontini rodents (Muridae, Sigmodontinae)"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045715347072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anatomy"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045785679104","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"VESTIGIALIZATION AND LOSS OF NONFUNCTIONAL CHARACTERS"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519768990592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Extrahepatic Biliary Tract in Chinchilla (<i>Chinchilla laniger</i>, Molina)"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520875593984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bile salt evolution"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981469951639680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gene expression in the embryonic Xenopus liver"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471456113536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The extrahepatic biliary tract of the camel"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471463257856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The biliary tract of certain rodents with and those without a gall bladder"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262943523699456","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Progressive Loss of Function in a Limb Enhancer during Snake Evolution"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945102658688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Multipotent stem/progenitor cells in human biliary tree give rise to hepatocytes, cholangiocytes, and pancreatic islets"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262945710160128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An anterograde tracing study of the vagal innervation of rat liver, portal vein and biliary system"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946146602368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The septum transversum mesenchyme induces gall bladder development"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419804300672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Surgical anatomy of the liver, hepatic vasculature and bile ducts in the rat"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825893934839552","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Redundant roles of<i>Sox17</i>and<i>Sox18</i>in postnatal angiogenesis in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894754516992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895725801216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The general function of the gall bladder. Do species lacking a gall bladder possess its functional equivalent? the bile and pigment output of various species of animals"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370265008896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Liver development in the rat and in man during the embryonic period (Carnegie stages 11-23)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843741037440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The development of the pars intestinalis of the common bile duct in the human fetus, with special reference to the origin of the ampulla of vater and the sphincter of oddi"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844114742784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A glimpse on the pattern of rodent diversification: a phylogenetic approach"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846294195072","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comparative morphology of the gallbladder and biliary tract in vertebrates: Variation in structure, homology in function and gallstones"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318261710848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pancreas Development in Zebrafish: Early Dispersed Appearance of Endocrine Hormone Expressing Cells and Their Convergence to Form the Definitive Islet"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318342144896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319321474432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Sox17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796186901632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The extrahepatic biliary tract in common domestic and laboratory animals"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268836350336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Xenopus pancreas development"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269071479424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a\n                    <i>Pitx1</i>\n                    Enhancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233269374484096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"On the development of the biliary system in animals lacking a gall‐bladder in postnatal life"}]},{"@id":"https://cir.nii.ac.jp/crid/1370283693315729545","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Studies of the anatomy of the extrahepatic biliary tract in Mammalia"}]},{"@id":"https://cir.nii.ac.jp/crid/1370283693315729550","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"On the gall bladder of a giraffe"}]},{"@id":"https://cir.nii.ac.jp/crid/1370283693315729668","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Studies on the morphological changes of v. umbilicalis in the liver of embryonic stage"}]},{"@id":"https://cir.nii.ac.jp/crid/1370283693315729670","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biliary atresia in lampreys"}]},{"@id":"https://cir.nii.ac.jp/crid/1370283693315729676","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"General function of the gall bladder from the evolutionary standpoint"}]},{"@id":"https://cir.nii.ac.jp/crid/1370283693315729680","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Congenital absence of the gallbladder and cystic duct associated with primary carcinoma of the common bile duct"}]},{"@id":"https://cir.nii.ac.jp/crid/1370579814296313728","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Weight assessment of some accessory digestive organs in the adult african giant pouched rat (Cricetomys gambianus, Waterhouse‐1840)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206430407168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Gallbladder Agenesis in a Chihuahua"},{"@value":"Internal medicine: Gallbladder agenesis in a Chihuahua"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681406616064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Fate mapping of gallbladder progenitors in posteroventral foregut endoderm of          mouse early somite-stage embryos"},{"@value":"Anatomy : Fate mapping of gallbladder progenitors in posteroventral foregut endoderm of mouse early somite-stage embryos"}]},{"@id":"https://cir.nii.ac.jp/crid/1390288225750186880","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparative anatomy of the hepatobiliary systems in quail and pigeon, with a perspective for the gallbladder-loss"}]},{"@id":"https://cir.nii.ac.jp/crid/1572543024474763904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Origin and early development of the liver in various vertebrates."}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/joa.12707"},{"@type":"KAKEN","@value":"PRODUCT-21571810"},{"@type":"KAKEN","@value":"PRODUCT-25085641"},{"@type":"OPENAIRE","@value":"doi_dedup___::738939ff46e5ec77d860c7bfa7f028ff"},{"@type":"CROSSREF","@value":"10.1292/jvms.20-0669_references_DOI_9Q3j1IFYuHYSG4XhUHvezcQxmWP"},{"@type":"CROSSREF","@value":"10.1002/ar.25208_references_DOI_9Q3j1IFYuHYSG4XhUHvezcQxmWP"},{"@type":"CROSSREF","@value":"10.1038/s41598-022-05554-8_references_DOI_9Q3j1IFYuHYSG4XhUHvezcQxmWP"},{"@type":"CROSSREF","@value":"10.1038/s43856-024-00544-5_references_DOI_9Q3j1IFYuHYSG4XhUHvezcQxmWP"}]}