{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360283694068302720.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1242/dev.079590"}},{"identifier":{"@type":"URI","@value":"http://journals.biologists.com/dev/article-pdf/139/22/4111/1574037/4111.pdf"}},{"identifier":{"@type":"PMID","@value":"23093423"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"In vitro organogenesis in three dimensions: self-organising stem cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Organ formation during embryogenesis is a complex process that involves various local cell-cell interactions at the molecular and mechanical levels. Despite this complexity, organogenesis can be modelled in vitro. In this article, we focus on two recent examples in which embryonic stem cells can self-organise into three-dimensional structures – the optic cup and the pituitary epithelium; and one case of self-organising adult stem cells – the gut epithelium. We summarise how these approaches have revealed intrinsic programs that drive locally autonomous modes of organogenesis and homeostasis. We also attempt to interpret the results of previous in vivo studies of retinal development in light of the self-organising nature of the retina.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380006464162300674","@type":"Researcher","foaf:name":[{"@value":"Yoshiki Sasai"}],"jpcoar:affiliationName":[{"@value":"Neurogenesis and Organogenesis Group, RIKEN Center for Developmental Biology, Kobe, 650-0047, 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Eiraku"}],"jpcoar:affiliationName":[{"@value":"Unit of Four-Dimensional Tissue Analysis, RIKEN Center for Developmental Biology, Kobe, 650-0047, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380006464162300686","@type":"Researcher","foaf:name":[{"@value":"Hidetaka Suga"}],"jpcoar:affiliationName":[{"@value":"Neurogenesis and Organogenesis Group, RIKEN Center for Developmental Biology, Kobe, 650-0047, Japan"},{"@value":"Unit of Four-Dimensional Tissue Analysis, RIKEN Center for Developmental Biology, Kobe, 650-0047, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14779129"},{"@type":"PISSN","@value":"09501991"}],"prism:publicationName":[{"@value":"Development"}],"dc:publisher":[{"@value":"The Company of Biologists"}],"prism:publicationDate":"2012-11-15","prism:volume":"139","prism:number":"22","prism:startingPage":"4111","prism:endingPage":"4121"},"reviewed":"false","url":[{"@id":"http://journals.biologists.com/dev/article-pdf/139/22/4111/1574037/4111.pdf"}],"createdAt":"2012-10-23","modifiedAt":"2021-04-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Organogenesis","dc:title":"Organogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Differentiation","dc:title":"Cell Differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=Epithelial%20Cells","dc:title":"Epithelial Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Eye","dc:title":"Eye"},{"@id":"https://cir.nii.ac.jp/all?q=Retina","dc:title":"Retina"},{"@id":"https://cir.nii.ac.jp/all?q=Adult%20Stem%20Cells","dc:title":"Adult Stem Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Pituitary%20Gland","dc:title":"Pituitary Gland"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Intestinal%20Mucosa","dc:title":"Intestinal Mucosa"},{"@id":"https://cir.nii.ac.jp/all?q=Embryonic%20Stem%20Cells","dc:title":"Embryonic Stem Cells"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782224019712","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"24680037"},{"@type":"JGN","@value":"JP24680037"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24680037/"}],"notation":[{"@language":"ja","@value":"眼杯のパターン形成を制御する位置情報シグナルの３次元イメージングによる解析"},{"@language":"en","@value":"Dorsal and ventral specification in optic cup derived from ES cells in 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