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Carnitine/Organic Cation Transporter OCTN1 Negatively Regulates Activation in Murine Cultured Microglial Cells
Bibliographic Information
- Published
- 2018-01
- Resource Type
- journal article
- Rights Information
-
- http://www.springer.com/tdm
- http://www.springer.com/tdm
- DOI
-
- 10.1007/s11064-017-2350-5
- Publisher
- Springer Science and Business Media LLC
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Description
Brain immune cells, i.e., microglia, play an important role in the maintenance of brain homeostasis, whereas chronic overactivation of microglia is involved in the development of various neurodegenerative disorders. Therefore, the regulation of microglial activation may contribute to their treatment. The aim of the present study was to clarify the functional expression of carnitine/organic cation transporter OCTN1/SLC22A4, which recognizes the naturally occurring food-derived antioxidant ergothioneine (ERGO) as a substrate in vivo, in microglia and its role in regulation of microglial activation. Primary cultured microglia derived from wild-type mice (WT-microglia) and mouse microglial cell line BV2 exhibited time-dependent uptake of [
Journal
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- Neurochemical Research
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Neurochemical Research 43 (1), 116-128, 2018-01
Springer Science and Business Media LLC
