{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360285706976672640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.bbrc.2009.11.063"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X09022384?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X09022384?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"19913509"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis"}],"description":[{"notation":[{"@value":"In early-organogenesis-stage mouse embryos, the posteroventral foregut endoderm adjacent to the heart tube gives rise to liver, ventral pancreas and gallbladder. Hepatic and pancreatic primordia become specified in the posterior segment of the ventral foregut endoderm at early somite stages. The mechanisms for demarcating gallbladder and bile duct primordium, however, are poorly understood. Here, we demonstrate that the gallbladder and bile duct progenitors are specified in the paired lateral endoderm domains outside the heart field at almost the same timing as hepatic and pancreatic induction. In the anterior definitive endoderm, Sox17 reactivation occurs in a certain population within the most lateral domains posterolateral to the anterior intestinal portal (AIP) lip on both the left and right sides. During foregut formation, the paired Sox17-positive domains expand ventromedially to merge in the midline of the AIP lip and become localized between the liver and pancreatic primordia. In Sox17-null embryos, these lateral domains are missing, resulting in a complete loss of the gallbladder/bile-duct structure. Chimera analyses revealed that Sox17-null endoderm cells in the posteroventral foregut do not display any gallbladder/bile-duct molecular characters. Our findings show that Sox17 functions cell-autonomously to specify gallbladder/bile-duct in the mouse embryo."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380285706976672640","@type":"Researcher","foaf:name":[{"@value":"Mami Uemura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285706976672642","@type":"Researcher","foaf:name":[{"@value":"Kenshiro Hara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285706976672646","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Shitara"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276186227584","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50431838"},{"@type":"NRID","@value":"1000050431838"},{"@type":"NRID","@value":"9000248218167"},{"@type":"NRID","@value":"9000382098172"},{"@type":"NRID","@value":"9000292182046"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000011725"}],"foaf:name":[{"@value":"Naoki Tsunekawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285706976672650","@type":"Researcher","foaf:name":[{"@value":"Yutaroh Miura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285706976672644","@type":"Researcher","foaf:name":[{"@value":"Choji Taya"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285706976672649","@type":"Researcher","foaf:name":[{"@value":"Masamichi Kurohmaru"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285706976672647","@type":"Researcher","foaf:name":[{"@value":"Masami Kanai-Azuma"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751138209792","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30260326"},{"@type":"NRID","@value":"1000030260326"},{"@type":"NRID","@value":"9000000810924"},{"@type":"NRID","@value":"9000253282317"},{"@type":"NRID","@value":"9000009971527"},{"@type":"NRID","@value":"9000415337645"},{"@type":"NRID","@value":"9000415338236"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0123258"}],"foaf:name":[{"@value":"Yoshiakira Kanai"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285706976672648","@type":"Researcher","foaf:name":[{"@value":"Rie Ishii"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285706976672645","@type":"Researcher","foaf:name":[{"@value":"Hiromichi Yonekawa"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006291X"}],"prism:publicationName":[{"@value":"Biochemical and Biophysical Research Communications"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2010-01","prism:volume":"391","prism:number":"1","prism:startingPage":"357","prism:endingPage":"363"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006291X09022384?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006291X09022384?httpAccept=text/plain"}],"createdAt":"2009-11-13","modifiedAt":"2025-09-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Endoderm","dc:title":"Endoderm"},{"@id":"https://cir.nii.ac.jp/all?q=Gallbladder","dc:title":"Gallbladder"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Developmental","dc:title":"Gene Expression Regulation, Developmental"},{"@id":"https://cir.nii.ac.jp/all?q=Embryo,%20Mammalian","dc:title":"Embryo, Mammalian"},{"@id":"https://cir.nii.ac.jp/all?q=Intestines","dc:title":"Intestines"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=HMGB%20Proteins","dc:title":"HMGB Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Morphogenesis","dc:title":"Morphogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=SOXF%20Transcription%20Factors","dc:title":"SOXF Transcription Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Bile%20Ducts","dc:title":"Bile Ducts"},{"@id":"https://cir.nii.ac.jp/all?q=Intestinal%20Mucosa","dc:title":"Intestinal Mucosa"},{"@id":"https://cir.nii.ac.jp/all?q=Body%20Patterning","dc:title":"Body Patterning"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782066441600","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21248034"},{"@type":"JGN","@value":"JP21248034"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21248034/"}],"notation":[{"@language":"ja","@value":"内胚葉形成因子SOX17の肝臓、胆管、膵臓発生における役割"},{"@language":"en","@value":"Crucial roles of SOX17 in liver-gallbladder-pancreas development"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257024022272","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20590178"},{"@type":"JGN","@value":"JP20590178"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590178/"}],"notation":[{"@language":"ja","@value":"マウス初期内胚葉からその派生組織への分化過程におけるSox17因子の役割"},{"@language":"en","@value":"The role of Sox17 during mouse early endoderm to its delivertives"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004235994179456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sox17-Mediated Maintenance of Fetal Intra-Aortic Hematopoietic Cell Clusters"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145226501248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A glimpse into the molecular entrails of endoderm formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145799414272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Depletion of definitive gut endoderm in<i>Sox17</i>-null mutant mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693315729664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Anatomy and development of the extrahepatic biliary system in mouse and rat: a perspective on the 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mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370063314816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regionalisation of the endoderm progenitors and morphogenesis of the gut portals of the mouse embryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844177751168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844435195264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tissue-specific requirements for the proprotein convertase Furin/SPC1 during embryonic turning and heart looping"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388846004198912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Defective development of the gall bladder and cystic duct in <i>Lgr4</i>‐ hypomorphic 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