Oxidized albumin is associated with water retention and severity of disease in patients with chronic liver diseases

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Summary Background & aims Serum albumin exists in oxidized and reduced forms. Although oxidation of albumin affects some functions of albumin, the involvement of oxidized albumin in disease progression and water retention in patients with chronic liver disease remains unclear. The aim of this study was to determine whether there is an association between oxidized albumin and water retention in patients with chronic liver disease. Methods Seventy-nine patients with chronic viral liver diseases and 31 cirrhotic patients with hypoalbuminemia were enrolled. The oxidized albumin percentage was determined by high-performance liquid chromatography. Water retention was assessed by the extra cellular fluid/total body fluid ratio (ECF/TBF) using a bioelectrical impedance analyzer. Results The oxidized albumin percentage was significantly increased according to disease progression (chronic hepatitis; 28.3 ± 1.1, Child A; 33.5 ± 1.2, Child B and C; 37.8 ± 1.3, P  Conclusions Oxidized albumin was related to disease progression and water retention in patients with chronic liver disease.

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