{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360285707291670656.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.jphs.2016.03.004"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1347861316000396?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1347861316000396?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"27032909"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition"}],"description":[{"notation":[{"@value":"S-allyl-l-cysteine (SAC) is known to have neuroprotective properties. We synthesized various SAC derivatives and tested their effects on endoplasmic reticulum stress-induced neurotoxicity in cultured hippocampal neurons (HPNs). Among the compounds tested, S-propyl-l-cysteine (SPC) exhibited the strongest neuroprotective activity in HPNs, followed by S-ethyl-l-cysteine (SEC) and S-methyl-l-cysteine (SMC). Unlike SAC and SMC, SPC and SEC did not have inhibitory activity on μ-calpain, suggesting that the mechanism underlying the protective activity of SPC and SEC differs from that of SAC."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380285707291670660","@type":"Researcher","foaf:name":[{"@value":"Toru Imai"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276177310208","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70383726"},{"@type":"NRID","@value":"1000070383726"},{"@type":"NRID","@value":"9000001130534"},{"@type":"NRID","@value":"9000020896647"},{"@type":"NRID","@value":"9000296679201"},{"@type":"NRID","@value":"9000001678419"},{"@type":"NRID","@value":"9000263057007"},{"@type":"NRID","@value":"9000259320537"},{"@type":"NRID","@value":"9000392001294"},{"@type":"NRID","@value":"9000010161309"},{"@type":"NRID","@value":"9000317128861"},{"@type":"NRID","@value":"9000254367724"},{"@type":"NRID","@value":"9000261654894"},{"@type":"NRID","@value":"9000408481365"},{"@type":"NRID","@value":"9000369746623"},{"@type":"NRID","@value":"9000410164437"},{"@type":"NRID","@value":"9000408487683"},{"@type":"NRID","@value":"9000311506089"},{"@type":"NRID","@value":"9000408479884"},{"@type":"NRID","@value":"9000410164364"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0127131"}],"foaf:name":[{"@value":"Yasuhiro Kosuge"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285707291670657","@type":"Researcher","foaf:name":[{"@value":"Hiroaki Saito"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285707291670656","@type":"Researcher","foaf:name":[{"@value":"Taketo Uchiyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801206425600","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20597398"},{"@type":"NRID","@value":"1000020597398"},{"@type":"NRID","@value":"9000006297057"},{"@type":"NRID","@value":"9000329885640"},{"@type":"NRID","@value":"9000006243909"},{"@type":"NRID","@value":"9000002651494"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0165121"}],"foaf:name":[{"@value":"Taira Wada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285707291670665","@type":"Researcher","foaf:name":[{"@value":"Shigeki Shimba"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285707291670664","@type":"Researcher","foaf:name":[{"@value":"Kumiko Ishige"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285707291670663","@type":"Researcher","foaf:name":[{"@value":"Shinichi Miyairi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285707291670662","@type":"Researcher","foaf:name":[{"@value":"Makoto Makishima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285707291670658","@type":"Researcher","foaf:name":[{"@value":"Yoshihisa Ito"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13478613"}],"prism:publicationName":[{"@value":"Journal of Pharmacological Sciences"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2016-03","prism:volume":"130","prism:number":"3","prism:startingPage":"185","prism:endingPage":"188"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","http://creativecommons.org/licenses/by-nc-nd/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1347861316000396?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1347861316000396?httpAccept=text/plain"}],"createdAt":"2016-03-14","modifiedAt":"2018-09-14","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Neurons","dc:title":"Neurons"},{"@id":"https://cir.nii.ac.jp/all?q=Calpain","dc:title":"Calpain"},{"@id":"https://cir.nii.ac.jp/all?q=S-allyl-l-cysteine%20derivatives","dc:title":"S-allyl-l-cysteine derivatives"},{"@id":"https://cir.nii.ac.jp/all?q=RM1-950","dc:title":"RM1-950"},{"@id":"https://cir.nii.ac.jp/all?q=Endoplasmic%20Reticulum%20Stress","dc:title":"Endoplasmic Reticulum Stress"},{"@id":"https://cir.nii.ac.jp/all?q=Hippocampus","dc:title":"Hippocampus"},{"@id":"https://cir.nii.ac.jp/all?q=Neuroprotective%20Agents","dc:title":"Neuroprotective Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Hippocampal%20neuron","dc:title":"Hippocampal neuron"},{"@id":"https://cir.nii.ac.jp/all?q=Endoplasmic%20reticulum%20stress","dc:title":"Endoplasmic reticulum stress"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Therapeutics.%20Pharmacology","dc:title":"Therapeutics. 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