{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360285708459260032.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41598-017-16163-1"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41598-017-16163-1.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41598-017-16163-1"}},{"identifier":{"@type":"PMID","@value":"29150640"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Early endosome motility mediates α-amylase production and cell differentiation in Aspergillus oryzae"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Recent research in filamentous fungi has revealed that the motility of an endocytic organelle early endosome (EE) has a versatile role in many physiological functions. Here, to further examine the motility of EEs in the industrially important fungus<jats:italic>Aspergillus oryzae</jats:italic>, we visualized these organelles via the Rab5 homolog AoRab5 and identified AoHok1, a putative linker protein between an EE and a motor protein. The<jats:italic>Aohok1</jats:italic>disruptant showed retarded mycelial growth and no EE motility, in addition to an apical accumulation of EEs and peroxisomes. We further demonstrated that the<jats:italic>Aohok1</jats:italic>disruptant exhibited less sensitivity to osmotic and cell wall stresses. Analyses on the protein secretory pathway in Δ<jats:italic>Aohok1</jats:italic>cells showed that, although distribution of the endoplasmic reticulum and Golgi was not affected, formation of the apical secretory vesicle cluster Spitzenkörper was impaired, probably resulting in the observed reduction of the<jats:italic>A. oryzae</jats:italic>major secretory protein α-amylase. Moreover, we revealed that the transcript level of α-amylase-encoding gene<jats:italic>amyB</jats:italic>was significantly reduced in the<jats:italic>Aohok1</jats:italic>disruptant. Furthermore, we observed perturbed conidial and sclerotial formations, indicating a defect in cell differentiation, in the<jats:italic>Aohok1</jats:italic>disruptant. Collectively, our results suggest that EE motility is crucial for α-amylase production and cell differentiation in<jats:italic>A. oryzae</jats:italic>.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380285708459260037","@type":"Researcher","foaf:name":[{"@value":"Yusuke Togo"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801198747264","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50732765"},{"@type":"NRID","@value":"1000050732765"},{"@type":"ORCID","@value":"0000-0001-7309-291X"},{"@type":"NRID","@value":"9000291272471"},{"@type":"NRID","@value":"9000395374684"},{"@type":"NRID","@value":"9000381068929"},{"@type":"NRID","@value":"9000410037436"},{"@type":"NRID","@value":"9000410046200"},{"@type":"NRID","@value":"9000363279138"},{"@type":"NRID","@value":"9000411382348"},{"@type":"NRID","@value":"9000342443517"},{"@type":"NRID","@value":"9000257905243"},{"@type":"NRID","@value":"9000409192172"},{"@type":"NRID","@value":"9000018470201"},{"@type":"NRID","@value":"9000398611168"},{"@type":"NRID","@value":"9000369734176"},{"@type":"NRID","@value":"9000356663582"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/yujiro_higuchi"}],"foaf:name":[{"@value":"Yujiro Higuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285708459259915","@type":"Researcher","foaf:name":[{"@value":"Yoshinori Katakura"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285708459260160","@type":"Researcher","foaf:name":[{"@value":"Kaoru Takegawa"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20452322"}],"prism:publicationName":[{"@value":"Scientific Reports"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2017-11-17","prism:volume":"7","prism:number":"1","prism:startingPage":"15757"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41598-017-16163-1.pdf"},{"@id":"https://www.nature.com/articles/s41598-017-16163-1"}],"createdAt":"2017-11-13","modifiedAt":"2025-06-27","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Osmosis","dc:title":"Osmosis"},{"@id":"https://cir.nii.ac.jp/all?q=Mycelium","dc:title":"Mycelium"},{"@id":"https://cir.nii.ac.jp/all?q=Aspergillus%20oryzae","dc:title":"Aspergillus oryzae"},{"@id":"https://cir.nii.ac.jp/all?q=Secretory%20Vesicles","dc:title":"Secretory Vesicles"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Differentiation","dc:title":"Cell Differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=Endosomes","dc:title":"Endosomes"},{"@id":"https://cir.nii.ac.jp/all?q=Spores,%20Fungal","dc:title":"Spores, Fungal"},{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Biological","dc:title":"Models, Biological"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Fungal%20Proteins","dc:title":"Fungal Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Wall","dc:title":"Cell Wall"},{"@id":"https://cir.nii.ac.jp/all?q=Stress,%20Physiological","dc:title":"Stress, Physiological"},{"@id":"https://cir.nii.ac.jp/all?q=Peroxisomes","dc:title":"Peroxisomes"},{"@id":"https://cir.nii.ac.jp/all?q=alpha-Amylases","dc:title":"alpha-Amylases"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Deletion","dc:title":"Gene Deletion"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256902009600","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"16K18837"},{"@type":"JGN","@value":"JP16K18837"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18837/"}],"notation":[{"@language":"ja","@value":"“国菌”黄麹菌における初期エンドソーム動態の生理学的機能解析"},{"@language":"en","@value":"Analysis of physiological role of early endosome motility in the \"Japanese national fungus\" Aspergillus oryzae"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202619726208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"COPI is essential for Golgi cisternal maturation and dynamics"}]},{"@id":"https://cir.nii.ac.jp/crid/1050017057726844288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Correlative 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oryzae"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319518655744","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hook is an adapter that coordinates kinesin-3 and dynein cargo attachment on early endosomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320018888064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ER Contact Sites Define the Position and Timing of Endosome Fission"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793750411392","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A putative endosomal t-SNARE links exo- and endocytosis in the phytopathogenic fungus Ustilago maydis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794300071808","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Enhanced Production and Secretion of Heterologous Proteins by the Filamentous Fungus\n            <i>Aspergillus oryzae</i>\n            via Disruption of 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