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In the present study, we investigated whether intranasal administration of the effector function‐lacking Fabs of a monoclonal antibody IgG1 (mAb, P1‐8) to the major allergen Cry j1 of Japanese cedar pollen (JCP) suppressed JCP‐induced allergic rhinitis in mice.</jats:p></jats:sec><jats:sec><jats:title>Experimental Approach</jats:title><jats:p>Balb/c mice sensitized with JCP on days 0 and 14 were challenged intranasally with the pollen on days 28, 29, 30 and 35. Fabs prepared by the digestion of P1‐8 with papain were also administered intranasally 15 min before each JCP challenge.</jats:p></jats:sec><jats:sec><jats:title>Key Results</jats:title><jats:p>Intranasal administration of P1‐8 Fabs was followed by marked suppression of sneezing and nasal rubbing in mice with JCP‐induced allergic rhinitis. The suppression of these allergic symptoms by P1‐8 Fabs was associated with decreases in mast cells and eosinophils and decreased hyperplasia of goblet cells in the nasal mucosa.</jats:p></jats:sec><jats:sec><jats:title>Conclusions and Implications</jats:title><jats:p>These results demonstrated that intranasal exposure to P1‐8 Fabs was effective in suppressing JCP‐induced allergic rhinitis in mice, suggesting that allergen‐specific mAb Fabs might be used as a tool to regulate allergic pollinosis.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380285710462339972","@type":"Researcher","foaf:name":[{"@value":"S Yoshino"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology Kobe Pharmaceutical University  Kobe Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380285710462339845","@type":"Researcher","foaf:name":[{"@value":"N Mizutani"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology Kobe Pharmaceutical University  Kobe Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00071188"},{"@type":"EISSN","@value":"14765381"}],"prism:publicationName":[{"@value":"British Journal of Pharmacology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2016-04-06","prism:volume":"173","prism:number":"10","prism:startingPage":"1629","prism:endingPage":"1638"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fbph.13463"},{"@id":"https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bph.13463"}],"createdAt":"2016-02-20","modifiedAt":"2023-09-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20BALB%20C","dc:title":"Mice, Inbred BALB C"},{"@id":"https://cir.nii.ac.jp/all?q=Antibodies,%20Monoclonal","dc:title":"Antibodies, 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