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A case of pulmonary adenocarcinoma harboring osteoclast‐like giant cells: Its evaluation by immunohistochemical and genetic analyses
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- Ryoko Saito
- Department of Pathology Tohoku University School of Medicine Miyagi Japan
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- Fumiyoshi Fujishima
- Department of Pathology Tohoku University Hospital Miyagi Japan
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- Yasuhiro Nakamura
- Department of Pathology Tohoku University School of Medicine Miyagi Japan
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- Yasushi Hoshikawa
- Department of Thoracic Surgery Tohoku University Hospital Miyagi Japan
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- Shinji Taniuchi
- Department of Pathology Tohoku University Hospital Miyagi Japan
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- Atsuko Kasajima
- Department of Pathology Tohoku University Hospital Miyagi Japan
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- Mika Watanabe
- Department of Pathology Tohoku University Hospital Miyagi Japan
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- Yoshinori Okada
- Department of Thoracic Surgery Tohoku University Hospital Miyagi Japan
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- Hironobu Sasano
- Department of Pathology Tohoku University School of Medicine Miyagi Japan
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- Junya Tominaga
- Department of Radiology Tohoku University Hospital Miyagi Japan
Bibliographic Information
- Published
- 2016-03-03
- Resource Type
- journal article
- Rights Information
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/pin.12395
- Publisher
- Wiley
Search this article
Description
<jats:p>Tumors harboring osteoclast‐like giant cells (OGCs) at extraosseous site are extremely rare. These rare tumors have been detected most frequently in the pancreas and few pulmonary tumors harboring OGCs have been previously reported. In addition, the genetic profiles of these tumors have remained virtually unknown. Therefore, we report a case of pulmonary adenocarcinoma harboring OGCs in which <jats:italic>k‐ras</jats:italic> mutation and immunohistochemical study of proteins associated with OGCs were examined. The case was a 70‐year‐old man, who demonstrated a pulmonary mass associated with unusual radiological features. Histopathologically, three different cell types, mucinous adenocarcinoma cell, OGC and mononuclear cell were detected. OGCs were immunohistochemically negative for epithelial markers and positive for histiocytic markers but mononuclear cells were immunopositive for epithelial markers. In addition, both mononuclear and adenocarcinoma cells had the same <jats:italic>k‐ras</jats:italic> mutation profiles and mononuclear cells were immunohistochemically positive for macrophage colony‐stimulating factor (M‐CSF), one of the factors associated with OGC differentiation. Therefore, mononuclear cells were considered to be derived from neoplastic epithelium and OGCs could represent non‐neoplastic cells. In addition, M‐CSF locally produced could promote the differentiation of OGCs.</jats:p>
Journal
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- Pathology International
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Pathology International 66 (4), 224-229, 2016-03-03
Wiley
