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Incidence, Locations, and Longitudinal Course of Silent Microbleeds in Moyamoya Disease
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- Satoshi Kuroda
- From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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- Daina Kashiwazaki
- From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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- Tatsuya Ishikawa
- From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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- Naoki Nakayama
- From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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- Kiyohiro Houkin
- From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Bibliographic Information
- Other Title
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- A Prospective T2*-Weighted MRI Study
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Description
<jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p>Clinical significance of silent microbleeds is unknown in moyamoya disease. This study was aimed to clarify the incidence, locations, and longitudinal course.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p>This prospective cohort study included 78 nontreated patients with moyamoya disease. The incidence and locations of silent microbleeds were evaluated on T2*-weighted MRI. MR examinations were repeated every 6 or 12 months during a mean follow-up period of 43.1 months.</jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> T2*-weighted MRI identified silent microbleeds in 17 (29.3%) of 58 adult patients with moyamoya disease, but in none of 20 pediatric patients. During follow-up periods, de novo silent microbleeds developed in 4 (6.9%) of 58 adult patients. Hemorrhagic stroke occurred in 4 patients (6.9%), all of who had silent microbleeds on initial examination. The presence of silent microbleeds was a significant predictor for subsequent hemorrhagic stroke in adult moyamoya disease ( <jats:italic>P</jats:italic> <0.001). </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>Careful and long-term follow-up of silent microbleeds would be essential to improve their outcome in adult patients with moyamoya disease.</jats:p> </jats:sec>
Journal
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- Stroke
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Stroke 44 (2), 516-518, 2013-02
Ovid Technologies (Wolters Kluwer Health)