Suppression of SOX7 by DNA methylation and its tumor suppressor function in acute myeloid leukemia
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- Nelson Ng
- Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;
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- Christa Ho
- Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;
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- Cheuk Him Man
- Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;
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- Thomas S. K. Wan
- Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; and
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- Tsz Kan Fung
- Leukaemia and Stem Cell Biology Laboratory, Department of Haematological Medicine, King’s College London, London, United Kingdom;
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- Toshiyuki Tanaka
- Laboratory of Immunobiology, School of Pharmacy, Hyogo University of Health Sciences, Kobe, Japan
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- Haixia Wan
- Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;
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- Chi Wai Eric So
- Leukaemia and Stem Cell Biology Laboratory, Department of Haematological Medicine, King’s College London, London, United Kingdom;
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- Chae Yin Cher
- Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;
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- August Fan
- Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;
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- Yok Lam Kwong
- Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;
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- Anskar Y. H. Leung
- Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China;
書誌事項
- 公開日
- 2015-06-18
- 資源種別
- journal article
- DOI
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- 10.1182/blood-2014-06-580993
- 公開者
- American Society of Hematology
この論文をさがす
説明
<jats:title>Key Points</jats:title><jats:p>SOX7 expression is silenced in common myeloid malignancies. SOX7 interacts directly with β-catenin and regulates the Wnt pathway in acute myeloid leukemia.</jats:p>
収録刊行物
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- Blood
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Blood 125 (25), 3928-3936, 2015-06-18
American Society of Hematology
- Tweet
キーワード
- Myeloid
- Immunoblotting
- Mice, SCID
- Acute
- SCID
- Real-Time Polymerase Chain Reaction
- Cell Line
- Mice
- Mice, Inbred NOD
- Cell Line, Tumor
- SOXF Transcription Factors
- Animals
- Humans
- Genes, Tumor Suppressor
- Tumor
- Leukemia
- Reverse Transcriptase Polymerase Chain Reaction
- DNA Methylation
- Leukemia, Myeloid, Acute
- Genes
- Gene Expression Regulation
- Inbred NOD
- Heterografts
- Transcriptome
- Tumor Suppressor
- Signal Transduction
詳細情報 詳細情報について
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- CRID
- 1360285711736670592
-
- ISSN
- 15280020
- 00064971
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- PubMed
- 25940713
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- 資料種別
- journal article
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- データソース種別
-
- Crossref
- KAKEN
- OpenAIRE
