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Effects of Surface-Deacetylated Chitin Nanofibers in an Experimental Model of Hypercholesterolemia
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- Kazuo Azuma
- Department of Clinical Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan
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- Tomone Nagae
- Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan
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- Takeshi Nagai
- Japan Food Research Laboratories, Tama 206-0025, Japan
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- Hironori Izawa
- Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan
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- Minoru Morimoto
- Division of Instrumental Analysis, Research Center for Bioscience and Technology, Tottori University, Tottori 680-8550, Japan
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- Yusuke Murahata
- Department of Clinical Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan
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- Tomohiro Osaki
- Department of Clinical Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan
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- Takeshi Tsuka
- Department of Clinical Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan
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- Tomohiro Imagawa
- Department of Clinical Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan
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- Norihiko Ito
- Department of Clinical Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan
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- Yoshiharu Okamoto
- Department of Clinical Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan
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- Hiroyuki Saimoto
- Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan
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- Shinsuke Ifuku
- Graduate School of Engineering, Tottori University, Tottori 680-8552, Japan
Description
<jats:p>This study evaluated the effects of oral administration of surface-deacetylated chitin nanofibers (SDACNFs) on hypercholesterolemia using an experimental model. All rats were fed a high cholesterol diet with 1% w/w cholesterol and 0.5% w/w cholic acid for 28 days. Rats were divided equally into four groups: the control group was administered 0.05% acetic acid dissolved in tap water, and the SDACNF, chitosan (CS), and cellulose nanofiber (CLNF) groups were administered 0.1% CNF, CS, or CLNF dissolved in the tap water, respectively, during the experimental period. Changes in body weight, intake of food and water, and organ weight were measured. Serum blood chemistry and histopathological examination of the liver were performed. Administration of SDACNF did not affect body weight change, food and water intake, or organ weights. Administration of SDACNF and CS decreased the diet-induced increase in serum total cholesterol, chylomicron, very-low-density lipoprotein, and phospholipid levels on day 14. Moreover, oral administration of SDACNFs suppressed the increase of alanine transaminase levels on day 29 and suppressed vacuolar degeneration and accumulation of lipid droplets in liver tissue. These data indicate that SDACNF has potential as a functional food for patients with hypercholesterolemia.</jats:p>
Journal
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- International Journal of Molecular Sciences
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International Journal of Molecular Sciences 16 (8), 17445-17455, 2015-07-30
MDPI AG
