{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360286991675871360.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.brainres.2019.05.034"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006899319302896?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006899319302896?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"31145904"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Layilin enhances the invasive ability of malignant glioma cells via SNAI1 signaling"}],"description":[{"notation":[{"@value":"Malignant gliomas are characterized by high invasive ability. In this study, we investigated roles of layilin, a C-type lectin-homologous protein, in the invasive ability of malignant glioma cells.Expression of layilin was investigated by western blotting in the malignant glioma cell lines of U251-MG, A172, and T98G and in astrocytes. The effects of layilin-knockdown on the expression and protein levels of snail family transcriptional repressor 1 (SNAI1), a transcriptional factor involved in the acquisition and enhancement of invasive ability in malignant gliomas, and on the expression of its target genes, matrix metalloproteinase 2 (MMP2), MMP9, and collagen type I alpha 1 chain (COL1A1), were investigated by qPCR and/or western blotting. Furthermore, the effects of layilin-knockdown on the expression and protein levels of metastasis associated 1 family member 3 (MTA3), a transcriptional repressor of SNAI1, were also investigated by qPCR and western blotting. Finally, the effects of layilin-knockdown on the invasive ability of the cells were investigated by a wound healing assay.All the tested malignant glioma cells highly expressed layilin, compared to astrocytes, one of representative glial cell types. Layilin-knockdown reduced SNAI1 both at the mRNA and protein levels in A172 cells, and consequently mRNA levels of MMP2, MMP9, and COL1A1 were also reduced. Furthermore, layilin-knockdown increased nuclear protein levels of MTA3 in A172 cells. Notably, layilin-knockdown suppressed the invasive ability of the cells.Layilin up-regulates the expression of SNAI1 via down-regulation of MTA3. This process enhances the invasive ability of malignant glioma cells."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380286991675871363","@type":"Researcher","foaf:name":[{"@value":"Tomohiro 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Kato"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00068993"}],"prism:publicationName":[{"@value":"Brain Research"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2019-09","prism:volume":"1719","prism:startingPage":"140","prism:endingPage":"147"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006899319302896?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006899319302896?httpAccept=text/plain"}],"createdAt":"2019-05-27","modifiedAt":"2025-11-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Brain%20Neoplasms","dc:title":"Brain Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Glioma","dc:title":"Glioma"},{"@id":"https://cir.nii.ac.jp/all?q=Collagen%20Type%20I","dc:title":"Collagen Type I"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Proteins","dc:title":"Neoplasm Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Collagen%20Type%20I,%20alpha%201%20Chain","dc:title":"Collagen Type I, alpha 1 Chain"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation","dc:title":"Gene Expression Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Matrix%20Metalloproteinase%209","dc:title":"Matrix Metalloproteinase 9"},{"@id":"https://cir.nii.ac.jp/all?q=Astrocytes","dc:title":"Astrocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Matrix%20Metalloproteinase%202","dc:title":"Matrix Metalloproteinase 2"},{"@id":"https://cir.nii.ac.jp/all?q=Lectins,%20C-Type","dc:title":"Lectins, C-Type"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Invasiveness","dc:title":"Neoplasm Invasiveness"},{"@id":"https://cir.nii.ac.jp/all?q=Snail%20Family%20Transcription%20Factors","dc:title":"Snail Family Transcription Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription%20Factors","dc:title":"Transcription Factors"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782018080128","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K05721"},{"@type":"JGN","@value":"JP19K05721"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K05721/"}],"notation":[{"@language":"ja","@value":"再発性多発軟骨炎の診断を可能にする血清ペプチドの検出"},{"@language":"en","@value":"Detection of serum peptides enable the diagnosis of relapsing 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