{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360286994708317952.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1096/fj.201901955r"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1096%2Ffj.201901955R"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.201901955R"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1096/fj.201901955R"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/am-pdf/10.1096%2Ffj.201901955R"}},{"identifier":{"@type":"URI","@value":"https://faseb.onlinelibrary.wiley.com/doi/pdf/10.1096/fj.201901955R"}},{"identifier":{"@type":"PMID","@value":"32112485"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"EP3 signaling in dendritic cells promotes liver repair by inducing IL‐13‐mediated macrophage differentiation in mice"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    Macrophage plasticity is essential for liver wound healing; however, the mechanisms underlying macrophage phenotype switching are largely unknown. Dendritic cells (DCs) are critical initiators of innate immune responses; as such, they orchestrate inflammation following hepatic injury. Here, we subjected EP3‐deficient (Ptger3\n                    <jats:sup>−/−</jats:sup>\n                    ) and wild‐type (WT) mice to hepatic ischemia‐reperfusion (I/R) and demonstrate that signaling via the prostaglandin E (PGE) receptor EP3 in DCs regulates macrophage plasticity during liver repair. Compared with WT mice,\n                    <jats:italic>Ptger3</jats:italic>\n                    <jats:sup>−/−</jats:sup>\n                    mice showed delayed liver repair accompanied by reduced expression of hepatic growth factors and accumulation of Ly6C\n                    <jats:sup>low</jats:sup>\n                    reparative macrophages and monocyte‐derived DCs (moDCs). MoDCs were recruited to the boundary between damaged and undamaged liver tissue in an EP3‐dependent manner. Adoptive transfer of moDCs from\n                    <jats:italic>Ptger3</jats:italic>\n                    <jats:sup>−/−</jats:sup>\n                    mice resulted in impaired repair, along with increased numbers of Ly6C\n                    <jats:sup>high</jats:sup>\n                    inflammatory macrophages. Bone marrow macrophages (BMMs) up‐regulated expression of genes related to a reparative macrophage phenotype when co‐cultured with moDCs; this phenomenon was dependent on EP3 signaling. In the presence of an EP3 agonist, interleukin (IL)‐13 derived from moDCs drove BMMs to increase expression of genes characteristic of a reparative macrophage phenotype. The results suggest that EP3 signaling in moDCs facilitates liver repair by inducing IL‐13‐mediated switching of macrophage phenotype from pro‐inflammatory to pro‐reparative.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380286994708318082","@type":"Researcher","foaf:name":[{"@value":"Shuji Nakamoto"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Pharmacology Graduate School of Medical Sciences Kitasato University Sagamihara Japan"},{"@value":"Department of Pharmacology Kitasato University School of Medicine Sagamihara Japan"},{"@value":"Department of Surgery Kitasato University School of Medicine Sagamihara Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380286994708318083","@type":"Researcher","foaf:name":[{"@value":"Yoshiya Ito"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Pharmacology Graduate School of Medical Sciences Kitasato University Sagamihara Japan"},{"@value":"Department of Pharmacology Kitasato University School of Medicine Sagamihara Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751153126912","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60566925"},{"@type":"NRID","@value":"1000060566925"},{"@type":"NRID","@value":"9000258626222"},{"@type":"NRID","@value":"9000258626113"},{"@type":"NRID","@value":"9000017288489"},{"@type":"NRID","@value":"9000384356180"},{"@type":"NRID","@value":"9000384356191"},{"@type":"NRID","@value":"9000326656518"},{"@type":"NRID","@value":"9000411522775"},{"@type":"NRID","@value":"9000258627192"},{"@type":"NRID","@value":"9000368919069"},{"@type":"NRID","@value":"9000405687429"},{"@type":"NRID","@value":"9000406184058"},{"@type":"NRID","@value":"9000283668282"},{"@type":"NRID","@value":"9000258626207"},{"@type":"NRID","@value":"9000258626040"},{"@type":"NRID","@value":"9000347133297"},{"@type":"NRID","@value":"9000347133448"},{"@type":"NRID","@value":"9000347133285"},{"@type":"NRID","@value":"9000326656762"},{"@type":"NRID","@value":"9000326656710"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/60566925"}],"foaf:name":[{"@value":"Nobuyuki Nishizawa"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology Kitasato University School of Medicine Sagamihara Japan"},{"@value":"Department of Surgery Kitasato University School of Medicine Sagamihara Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380286994708318081","@type":"Researcher","foaf:name":[{"@value":"Takuya Goto"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Pharmacology Graduate School of Medical Sciences Kitasato University Sagamihara Japan"},{"@value":"Department of Pharmacology Kitasato University School of Medicine Sagamihara Japan"},{"@value":"Department of Surgery Kitasato University School of Medicine Sagamihara Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658699544448","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20525414"},{"@type":"NRID","@value":"1000020525414"}],"foaf:name":[{"@value":"Ken Kojo"}],"jpcoar:affiliationName":[{"@value":"Department of Surgery Kitasato University School of Medicine Sagamihara Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380286994708317953","@type":"Researcher","foaf:name":[{"@value":"Yusuke Kumamoto"}],"jpcoar:affiliationName":[{"@value":"Department of Surgery Kitasato University School of Medicine Sagamihara Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380286994708318208","@type":"Researcher","foaf:name":[{"@value":"Masahiko Watanabe"}],"jpcoar:affiliationName":[{"@value":"Department of Surgery Kitasato University School of Medicine Sagamihara Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380286994708318084","@type":"Researcher","foaf:name":[{"@value":"Shuh Narumiya"}],"jpcoar:affiliationName":[{"@value":"Center for Innovation in Immunoregulation Technology and Therapeutics Kyoto University Graduate School of Medicine Kyoto Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326234576896","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70181641"},{"@type":"NRID","@value":"1000070181641"},{"@type":"NRID","@value":"9000001646671"},{"@type":"NRID","@value":"9000259836007"},{"@type":"NRID","@value":"9000000400401"},{"@type":"NRID","@value":"9000283603956"},{"@type":"NRID","@value":"9000356588084"},{"@type":"NRID","@value":"9000283604056"},{"@type":"NRID","@value":"9000319068786"},{"@type":"NRID","@value":"9000021377969"},{"@type":"NRID","@value":"9000259835852"},{"@type":"NRID","@value":"9000388493730"},{"@type":"NRID","@value":"9000001824824"},{"@type":"NRID","@value":"9000020380428"},{"@type":"NRID","@value":"9000259835859"},{"@type":"NRID","@value":"9000283603863"},{"@type":"NRID","@value":"9000014197032"},{"@type":"NRID","@value":"9000020524373"},{"@type":"NRID","@value":"9000001766929"},{"@type":"NRID","@value":"9000309185816"},{"@type":"NRID","@value":"9000347361111"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/mmajima"}],"foaf:name":[{"@value":"Masataka Majima"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Pharmacology Graduate School of Medical Sciences Kitasato University Sagamihara Japan"},{"@value":"Department of Pharmacology Kitasato University School of Medicine Sagamihara Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08926638"},{"@type":"EISSN","@value":"15306860"}],"prism:publicationName":[{"@value":"The FASEB Journal"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2020-02-28","prism:volume":"34","prism:number":"4","prism:startingPage":"5610","prism:endingPage":"5627"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1096%2Ffj.201901955R"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1096/fj.201901955R"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1096/fj.201901955R"},{"@id":"https://onlinelibrary.wiley.com/doi/am-pdf/10.1096%2Ffj.201901955R"},{"@id":"https://faseb.onlinelibrary.wiley.com/doi/pdf/10.1096/fj.201901955R"}],"createdAt":"2020-02-29","modifiedAt":"2025-10-28","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-13","dc:title":"Interleukin-13"},{"@id":"https://cir.nii.ac.jp/all?q=Liver%20Diseases","dc:title":"Liver Diseases"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophages","dc:title":"Macrophages"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Differentiation","dc:title":"Cell Differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=Dendritic%20Cells","dc:title":"Dendritic Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Prostaglandin%20E,%20EP3%20Subtype","dc:title":"Receptors, Prostaglandin E, EP3 Subtype"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782004740352","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18K16373"},{"@type":"JGN","@value":"JP18K16373"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16373/"}],"notation":[{"@language":"ja","@value":"プロスタグランジンを介した肝樹状細胞の肝修復における役割解明"},{"@language":"en","@value":"Role of dendritic cells in liver repiar via prostaglandin receptor signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256970022912","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H02605"},{"@type":"JGN","@value":"JP18H02605"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02605/"}],"notation":[{"@language":"ja","@value":"リンパ管、リンパ組織の可塑性を制御する生理活性脂質の解析と治療応用への基盤研究"},{"@language":"en","@value":"Bioactive lipids as regulators of plasticity of lymphatics"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256996336000","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K09156"},{"@type":"JGN","@value":"JP19K09156"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K09156/"}],"notation":[{"@language":"ja","@value":"リンパ管可塑性による肝組織修復と制御機構の解明"},{"@language":"en","@value":"Lymphangiogenesis during liver repair after acute liver injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1040285300705251328","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20K17630"},{"@type":"JGN","@value":"JP20K17630"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K17630/"}],"notation":[{"@language":"ja","@value":"肝NKT細胞を基軸とする肝修復制御機構の解明"},{"@language":"en","@value":"Underlying mechanism of liver repair mediated by iNKT cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1040848250658698240","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20K17702"},{"@type":"JGN","@value":"JP20K17702"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K17702/"}],"notation":[{"@language":"ja","@value":"脂質メディエーターを介したリンパ管新生による炎症性腸疾患制御"},{"@language":"en","@value":"Lipid mediators regulate inflammatory bowel diseases via lymphangiogenesis"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002219445971712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"VEGFR1-Positive Macrophages Facilitate Liver Repair and Sinusoidal Reconstruction after Hepatic Ischemia/Reperfusion Injury"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144420305408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Significance and Therapeutic Potential of Prostaglandin E2 Receptor in Hepatic 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