{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360290617536300288.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41467-020-19279-7"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-020-19279-7.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-020-19279-7"}},{"identifier":{"@type":"PMID","@value":"33110091"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    De novo DNA methylation (DNAme) during mammalian spermatogenesis yields a densely methylated genome, with the exception of CpG islands (CGIs), which are hypomethylated in sperm. While the paternal genome undergoes widespread DNAme loss before the first S-phase following fertilization, recent mass spectrometry analysis revealed that the zygotic paternal genome is paradoxically also subject to a low level of de novo DNAme. However, the loci involved, and impact on transcription were not addressed. Here, we employ allele-specific analysis of whole-genome bisulphite sequencing data and show that a number of genomic regions, including several dozen CGI promoters, are de novo methylated on the paternal genome by the 2-cell stage. A subset of these promoters maintains DNAme through development to the blastocyst stage. Consistent with paternal DNAme acquisition, many of these loci are hypermethylated in androgenetic blastocysts but hypomethylated in parthenogenetic blastocysts. Paternal DNAme acquisition is lost following maternal deletion of\n                    <jats:italic>Dnmt3a</jats:italic>\n                    , with a subset of promoters, which are normally transcribed from the paternal allele in blastocysts, being prematurely transcribed at the 4-cell stage in maternal\n                    <jats:italic>Dnmt3a</jats:italic>\n                    knockout embryos. These observations uncover a role for maternal DNMT3A activity in post-fertilization epigenetic reprogramming and transcriptional silencing of the paternal genome.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380290617536300421","@type":"Researcher","foaf:name":[{"@value":"Julien Richard Albert"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617536300557","@type":"Researcher","foaf:name":[{"@value":"Wan Kin Au Yeung"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617536300302","@type":"Researcher","foaf:name":[{"@value":"Keisuke Toriyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617536300291","@type":"Researcher","foaf:name":[{"@value":"Hisato Kobayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617536300553","@type":"Researcher","foaf:name":[{"@value":"Ryutaro Hirasawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617536300428","@type":"Researcher","foaf:name":[{"@value":"Julie Brind’Amour"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617536300430","@type":"Researcher","foaf:name":[{"@value":"Aaron Bogutz"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326207979008","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30183825"},{"@type":"NRID","@value":"1000030183825"},{"@type":"ORCID","@value":"0000-0001-8239-8275"},{"@type":"CINII_AUTHOR_ID","@value":"DA14449538"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA14449538#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA14449538"},{"@type":"NRID","@value":"9000001758644"},{"@type":"NRID","@value":"9000002735810"},{"@type":"NRID","@value":"9000253176762"},{"@type":"NRID","@value":"9000000360519"},{"@type":"NRID","@value":"9000019185732"},{"@type":"NRID","@value":"9000014625483"},{"@type":"NRID","@value":"9000412110305"},{"@type":"NRID","@value":"9000253179756"},{"@type":"NRID","@value":"9000253167396"},{"@type":"NRID","@value":"9000364095070"},{"@type":"NRID","@value":"9000001182252"},{"@type":"NRID","@value":"9000262363512"},{"@type":"NRID","@value":"9000270141603"},{"@type":"NRID","@value":"9000369354272"},{"@type":"NRID","@value":"9000253175402"},{"@type":"NRID","@value":"9000023387070"},{"@type":"NRID","@value":"9000000362985"},{"@type":"NRID","@value":"9000259341647"},{"@type":"NRID","@value":"9000409360025"},{"@type":"NRID","@value":"9000024893917"},{"@type":"NRID","@value":"9000262363523"},{"@type":"NRID","@value":"9000376923014"},{"@type":"NRID","@value":"9000391612359"},{"@type":"NRID","@value":"9000006222550"},{"@type":"NRID","@value":"9000253177441"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0001709"}],"foaf:name":[{"@value":"Hiroyuki Sasaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617536300293","@type":"Researcher","foaf:name":[{"@value":"Matthew Lorincz"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1891709542766182145","@type":"Researcher","foaf:name":[{"@value":"Department of Medical Genetics, University of British Columbia"}]},{"@id":"https://cir.nii.ac.jp/crid/1891709542766182020","@type":"Researcher","foaf:name":[{"@value":"Division of Epigenomics and Development, Medical Institute of Bioregulation, Kyushu University"}]},{"@id":"https://cir.nii.ac.jp/crid/1891709542766182146","@type":"Researcher","foaf:name":[{"@value":"NODAI Genome Research Center, Tokyo University of Agriculture"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20411723"}],"prism:publicationName":[{"@value":"Nature Communications"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2020-10-27","prism:volume":"11","prism:number":"1","prism:startingPage":"5417"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41467-020-19279-7.pdf"},{"@id":"https://www.nature.com/articles/s41467-020-19279-7"}],"createdAt":"2020-10-27","modifiedAt":"2022-12-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Epigenomics","dc:title":"Epigenomics"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=%5BSDV%5DLife%20Sciences%20%5Bq-bio%5D","dc:title":"[SDV]Life Sciences [q-bio]"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Methyltransferase%203A","dc:title":"DNA Methyltransferase 3A"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20(Cytosine-5-)-Methyltransferases","dc:title":"DNA (Cytosine-5-)-Methyltransferases"},{"@id":"https://cir.nii.ac.jp/all?q=Alleles","dc:title":"Alleles"},{"@id":"https://cir.nii.ac.jp/all?q=Genome","dc:title":"Genome"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Developmental","dc:title":"Gene Expression Regulation, Developmental"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Methylation","dc:title":"DNA Methylation"},{"@id":"https://cir.nii.ac.jp/all?q=Spermatozoa","dc:title":"Spermatozoa"},{"@id":"https://cir.nii.ac.jp/all?q=Blastocyst","dc:title":"Blastocyst"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20DBA","dc:title":"Mice, Inbred DBA"},{"@id":"https://cir.nii.ac.jp/all?q=Oocytes","dc:title":"Oocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Paternal%20Inheritance","dc:title":"Paternal Inheritance"},{"@id":"https://cir.nii.ac.jp/all?q=CpG%20Islands","dc:title":"CpG Islands"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Maternal%20Inheritance","dc:title":"Maternal Inheritance"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256971482112","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H05214"},{"@type":"JGN","@value":"JP18H05214"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H05214/"}],"notation":[{"@language":"ja","@value":"多階層オミックスによる卵子の発生能制御分子ネットワークの解明"},{"@language":"en","@value":"Omics approaches towards the elucidation of the molecular network regulating the developmental capacity of the mammalian oocyte"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202560823936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1050015520409311872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Five nucleotides found in RCTG motifs are essential for post-fertilization methylation imprinting of the H19 ICR in YAC transgenic mice"},{"@value":"Five nucleotides found in RCTG motifs are essential for post-fertilization methylation imprinting of the <i>H19</i> ICR in YAC transgenic mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1050567175345790464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus"}]},{"@id":"https://cir.nii.ac.jp/crid/1050577541485176960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The transgenic IG-DMR sequence of the mouse Dlk1-Dio3 domain acquired imprinted DNA methylation during the post-fertilization period"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002218989226112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Software updates in the Illumina HiSeq platform affect whole-genome bisulfite sequencing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219385799808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004234948370944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004240542488320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011142935324032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011142936263680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011142937070720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145167280640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145500161536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Active demethylation of the paternal genome in the mouse zygote"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145799410944","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transient reduction of DNA methylation at the onset of meiosis in male mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145940920832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Resetting Epigenetic Memory by Reprogramming of Histone Modifications in Mammals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022307166696960","@type":"Article","resourceType":"preprint","relationType":["hasPreprint"],"jpcoar:relatedTitle":[{"@value":"Maternal DNMT3A-dependent de novo methylation of the zygotic paternal genome inhibits gene expression in the early embryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691777698432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"De novo DNA methylation drives 5hmC accumulation in mouse zygotes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693965724032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707021691904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709924606592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>Setdb1</i>\n                    is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620037374976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development of androgenetic mouse embryos produced by in vitro fertilization of enucleated oocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620067171968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621544488192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A unique regulatory phase of DNA methylation in the early mammalian embryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182467187328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186931574656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>De novo</i>DNA methylation through 5'-segment of the<i>H19</i>ICR maintains its imprint during early embryogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187584291328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNMTs and SETDB1 function as co-repressors in MAX-mediated repression of germ cell–related genes in mouse embryonic stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574092884632576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Trimmomatic: a flexible trimmer for Illumina sequence data"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574092887928192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095736728192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095871963904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Expression of Cre recombinase in mouse oocytes: A means to study maternal effect genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096058100864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Differential roles of Stella in the modulation of DNA methylation during oocyte and zygotic development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360845538917134720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dnmt3L and the Establishment of Maternal Genomic Imprints"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642720679680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643934050432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846644312757504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Mouse Oocyte Methylomes at Base Resolution Reveal Genome-Wide Accumulation of Non-CpG Methylation and Role of DNA Methyltransferases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656974998912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Re-evaluating the Localization of Sperm-Retained Histones Revealed the Modification-Dependent Accumulation in Specific Genome Regions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658397461504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855567860583040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569029159808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569066150912","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reprogramming of H3K9me3-dependent\n                            heterochromatin during mammalian embryo development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570240335360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570770441984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular determinants of nucleosome retention at CpG-rich sequences in mouse spermatozoa"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707114667648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Low Input Genome-Wide DNA Methylation Analysis with Minimal Library Amplification"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043774053376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Post-implantation development of mouse androgenetic embryos produced by in-vitro fertilization of enucleated oocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043849821056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Ontogeny of CpG island methylation and specificity of DNMT3 methyltransferases during embryonic development in the mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045717587328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"BEDOPS: high-performance genomic feature operations"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045810125184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Maternal-Zygotic Effect Gene, Zfp57, Maintains Both Maternal and Paternal Imprints"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046182112640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MEME SUITE: tools for motif discovery and searching"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046213797248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Allelic reprogramming of the histone modification H3K4me3 in early mammalian development"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518789218560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dynamic Reprogramming of DNA Methylation in the Early Mouse Embryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520370533632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genome-wide Bisulfite Sequencing in Zygotes Identifies Demethylation Targets and Maps the Contribution of TET3 Oxidation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520711705088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dynamic changes in histone modifications precede de novo DNA methylation in oocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993850386560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DNA methylation dynamics of the human preimplantation embryo"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994596796032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dynamic CpG island methylation landscape in oocytes and preimplantation 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