{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360290617685678080.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.wneu.2019.09.144"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1878875019325884?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1878875019325884?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"32545000"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Revascularization Surgery in Childhood Associated with a Low Incidence of Microbleeds in Adult Patients with Moyamoya"}],"description":[{"notation":[{"@value":"The clinical significance of asymptomatic microbleeds in moyamoya disease remains unclear. The purpose of this study was to clarify the relationship between bypass surgery and the incidence of asymptomatic microbleeds.This retrospective study included 142 adult patients (mean age, 37.7 ± 13.5 years) with moyamoya disease, 36 of whom (25.3%) underwent bypass surgery in childhood. Hemorrhagic onset was diagnosed in 31 patients (21.8%). The incidence of microbleeds was evaluated on T2*-weighted or susceptibility-weighted imaging from 3-T magnetic resonance imaging. The patients were subsequently categorized into MBs (microbleeds) or non-MBs groups. Because previous microbleeds potentially lead to hemorrhage, the MBs group was defined as patients with radiographic evidence of bleeding, including asymptomatic microbleeds and/or hemorrhagic onset. The association of baseline characteristics was evaluated.Asymptomatic microbleeds were detected in 38 patients (26.8%). Of 31 patients with hemorrhagic onset, 18 had microbleeds, whereas 13 had no microbleeds. Therefore, 51 patients (35.9%) were classified into the MBs group. Bypass surgery in childhood (MBs, 7.8% vs. non-MBs, 35.2%; P0.01) and age (MBs, 42.9 ± 1.8 years vs. non-MBs, 34.7 ± 1.4 years; P0.01) were statistically significant factors associated with microbleeds, but only bypass surgery in childhood remained statistically significant after multivariable adjustment (odds ratio, 0.25; 95% confidence interval, 0.07-0.87; P = 0.03).This study shows the clinical significance of revascularization surgery in childhood associated with a low incidence of asymptomatic microbleeds in adult patients with moyamoya disease. This finding indicates that a newly established bypass can reduce hemodynamic overstress."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380290617685678080","@type":"Researcher","foaf:name":[{"@value":"Yukihiro Yamao"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617685678214","@type":"Researcher","foaf:name":[{"@value":"Jun C. Takahashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617685678096","@type":"Researcher","foaf:name":[{"@value":"Takeshi Funaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617685678086","@type":"Researcher","foaf:name":[{"@value":"Yohei Mineharu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617685678083","@type":"Researcher","foaf:name":[{"@value":"Takyuki Kikuchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617685678089","@type":"Researcher","foaf:name":[{"@value":"Tomohisa Okada"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617685678093","@type":"Researcher","foaf:name":[{"@value":"Kaori Togashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801200262016","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70239440"},{"@type":"NRID","@value":"1000070239440"},{"@type":"CINII_AUTHOR_ID","@value":"DA1661166X"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA1661166X#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA1661166X"},{"@type":"NRID","@value":"9000263055448"},{"@type":"NRID","@value":"9000003624665"},{"@type":"NRID","@value":"9000003606346"},{"@type":"NRID","@value":"9000248247606"},{"@type":"NRID","@value":"9000023351024"},{"@type":"NRID","@value":"9000396135194"},{"@type":"NRID","@value":"9000019067295"},{"@type":"NRID","@value":"9000003592912"},{"@type":"NRID","@value":"9000238134224"},{"@type":"NRID","@value":"9000261036738"},{"@type":"NRID","@value":"9000020643157"},{"@type":"NRID","@value":"9000240522205"},{"@type":"NRID","@value":"9000020632715"},{"@type":"NRID","@value":"9000314796044"},{"@type":"NRID","@value":"9000263055481"},{"@type":"NRID","@value":"9000005096186"},{"@type":"NRID","@value":"9000409315499"},{"@type":"NRID","@value":"9000023653255"},{"@type":"NRID","@value":"9000237868328"},{"@type":"NRID","@value":"9000242579259"},{"@type":"NRID","@value":"9000261036719"},{"@type":"NRID","@value":"9000282394335"},{"@type":"NRID","@value":"9000242076752"},{"@type":"NRID","@value":"9000002006981"},{"@type":"NRID","@value":"9000242076997"},{"@type":"NRID","@value":"9000242076944"},{"@type":"NRID","@value":"9000024509340"},{"@type":"NRID","@value":"9000239867948"},{"@type":"NRID","@value":"9000019184079"},{"@type":"NRID","@value":"9000022227562"},{"@type":"NRID","@value":"9000370253140"},{"@type":"NRID","@value":"9000019184093"},{"@type":"NRID","@value":"9000263055506"},{"@type":"NRID","@value":"9000020037256"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000008876"}],"foaf:name":[{"@value":"Susumu Miyamoto"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"18788750"}],"prism:publicationName":[{"@value":"World Neurosurgery"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2020-01","prism:volume":"133","prism:startingPage":"e716","prism:endingPage":"e721"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1878875019325884?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1878875019325884?httpAccept=text/plain"}],"createdAt":"2019-10-04","modifiedAt":"2025-10-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Cerebral%20Revascularization","dc:title":"Cerebral Revascularization"},{"@id":"https://cir.nii.ac.jp/all?q=Incidence","dc:title":"Incidence"},{"@id":"https://cir.nii.ac.jp/all?q=Magnetic%20Resonance%20Imaging","dc:title":"Magnetic Resonance Imaging"},{"@id":"https://cir.nii.ac.jp/all?q=Cross-Sectional%20Studies","dc:title":"Cross-Sectional Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Moyamoya%20Disease","dc:title":"Moyamoya Disease"},{"@id":"https://cir.nii.ac.jp/all?q=Child","dc:title":"Child"},{"@id":"https://cir.nii.ac.jp/all?q=Cerebral%20Hemorrhage","dc:title":"Cerebral Hemorrhage"},{"@id":"https://cir.nii.ac.jp/all?q=Retrospective%20Studies","dc:title":"Retrospective Studies"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782014836864","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19H03770"},{"@type":"JGN","@value":"JP19H03770"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03770/"}],"notation":[{"@language":"ja","@value":"RNF213関連閉塞性血管障害の分子機序解明と新規治療開発"},{"@language":"en","@value":"Identification of molecular mechanisms of RNF213-related occlusive cerebrovascular diseases and development of new treatment strategies"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232328292352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Spatial Relationship between Cerebral Microbleeds, Moyamoya Vessels, and Hematoma in Moyamoya Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145456117120","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of Extracranial–Intracranial Bypass for Patients With Hemorrhagic Moyamoya Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021391871208704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"“Transcallosal” periventricular anastomosis in moyamoya disease: the fourth periventricular anastomosis and a potential predictor of hemorrhage"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711415205760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Incidence, Locations, and Longitudinal Course of Silent Microbleeds in Moyamoya Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618855362688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cerebrovascular \"Moyamoya\" Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619553235840","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"THE PRESENCE OF MULTIPLE MICROBLEEDS AS A PREDICTOR OF SUBSEQUENT CEREBRAL HEMORRHAGE IN PATIENTS WITH MOYAMOYA DISEASE"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165285083648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Incidence of late cerebrovascular events after direct bypass among children with moyamoya disease: a descriptive longitudinal study at a single center"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170529841792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impact of posterior cerebral artery involvement on long-term clinical and social outcome of pediatric moyamoya disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189351540096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hemorrhagic Moyamoya Disease : A Recent Update"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094400364032","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Significance of the Hemorrhagic Site for Recurrent Bleeding"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095701651712","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long-term outcome after STA-MCA anastomosis for moyamoya disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118835760256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Case of <i>de novo</i> cerebral microbleeds in ischemic-type pediatric moyamoya disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568894479872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In vivo demonstration of blood-brain barrier impairment in Moyamoya disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855571415360512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Incidence, Locations, and Longitudinal Course of Cerebral Microbleeds in European Moyamoya"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045355582592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hemorrhage and risk of further hemorrhagic strokes following cerebral revascularization in Moyamoya disease: A review of the literature"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045972357888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Silent Cerebral Microbleeds on T2*-Weighted MRI"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419976833920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Asymptomatic Cerebral Microbleeds in Adult Patients with Moyamoya Disease: A Prospective Cohort Study with 2 Years of Follow-Up"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894699482368","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clinical Associations of Cerebral Microbleeds on Magnetic Resonance Neuroimaging"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895954149760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Frequency and Location of Microbleeds in Patients With Primary Intracerebral Hemorrhage"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370960953472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Moyamoya disease: current concepts and future perspectives"}]},{"@id":"https://cir.nii.ac.jp/crid/1370290617685678081","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds"}]},{"@id":"https://cir.nii.ac.jp/crid/1370290617685678084","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Asymptomatic microbleeds in moyamoya disease: T2*-weighted gradient-echo magnetic resonance imaging study"}]},{"@id":"https://cir.nii.ac.jp/crid/1370290617685678087","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Angiographic features of hemorrhagic moyamoya disease with high recurrence risk: a supplementary analysis of the Japan Adult Moyamoya Trial"}]},{"@id":"https://cir.nii.ac.jp/crid/1370290617685678094","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Study of the posterior circulation in moyamoya disease. Clinical and neuroradiological evaluation"}]},{"@id":"https://cir.nii.ac.jp/crid/1370290617685678096","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Long-term follow-up study after extracranial-intracranial bypass surgery for anterior circulation ischemia in childhood moyamoya disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205057203840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Guidelines for Diagnosis and Treatment of Moyamoya Disease (Spontaneous Occlusion of the Circle of Willis)"},{"@value":"Health Labour Sciences Research Grant for Research on Measures for Infractable Diseases. Guidelines for diagnosis and treatment of moyamoya disease (spontaneous occlusion of the circle of Willis)"},{"@value":"Guidelines for the diagnosis and treatment of Moyamoya disease (spontaneous occlusion of the circle of Willis)."},{"@value":"and treatment of moyamoya disease (spontaneous occlusion of the circle of Willis)"},{"@value":"Treatment of spontaneous occlusion of the circle of W, health labour sciences research grant for research on measures for infractable D. Guidelines for diagnosis and treatment of moyamoya disease (spontaneous occlusion of the circle of Willis)"},{"@value":"Spontaneous Occlusion of the Circle of Willis. Guidelines for diagnosis and treatment of moyamoya disease (spontaneous occlusion of the circle of Willis)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564237991499648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Late Cerebrovascular Events and Social Outcome after Adolescence: Long-term Outcome of Pediatric Moyamoya Disease"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.wneu.2019.09.144"},{"@type":"KAKEN","@value":"PRODUCT-23540474"},{"@type":"OPENAIRE","@value":"doi_dedup___::1f3de4d635822c7d859c1ede4cd68525"},{"@type":"CROSSREF","@value":"10.1016/j.jstrokecerebrovasdis.2023.107428_references_DOI_JzGFyrCCdPs9A49onJiVHB4BVyJ"},{"@type":"CROSSREF","@value":"10.25259/sni_305_2021_references_DOI_JzGFyrCCdPs9A49onJiVHB4BVyJ"}]}