{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360290617866445824.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3389/fimmu.2021.639844"}},{"identifier":{"@type":"URI","@value":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.639844/full"}},{"identifier":{"@type":"PMID","@value":"33732260"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Pathologically Relevant Mouse Models for Epstein–Barr Virus–Associated B Cell Lymphoma"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The Epstein–Barr virus (EBV) is endemic in humans and can efficiently transform infected B cells under some circumstances. If an EBV carrier experiences immune suppression, EBV<jats:sup>+</jats:sup> B cells can turn into lymphoblasts and exhibit growth expansion that may cause lymphoproliferative diseases which often develop into lymphoma. Our immune system conducts surveillance for EBV<jats:sup>+</jats:sup> B cells in order to block spontaneous tumor formation. Here, we summarize the EBV products involved in tumorigenesis, EBV-associated lymphomas, and pathologically relevant mouse models. Preclinical mouse models for a range of EBV-associated diseases not only clear the path to new therapeutic approaches but also aid in our understanding of the nature of lymphomagenesis and immune surveillance.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380290617866445963","@type":"Researcher","foaf:name":[{"@value":"Shiyu Huang"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326220369792","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"40334429"},{"@type":"NRID","@value":"1000040334429"},{"@type":"NRID","@value":"9000002039702"},{"@type":"NRID","@value":"9000398802204"},{"@type":"NRID","@value":"9000399833400"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0099505"}],"foaf:name":[{"@value":"Tomoharu Yasuda"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"16643224"}],"prism:publicationName":[{"@value":"Frontiers in Immunology"}],"dc:publisher":[{"@value":"Frontiers Media SA"}],"prism:publicationDate":"2021-02-24","prism:volume":"12"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.frontiersin.org/articles/10.3389/fimmu.2021.639844/full"}],"createdAt":"2021-02-24","modifiedAt":"2021-02-24","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Epstein-Barr%20Virus%20Infections","dc:title":"Epstein-Barr Virus Infections"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphoma,%20B-Cell","dc:title":"Lymphoma, B-Cell"},{"@id":"https://cir.nii.ac.jp/all?q=immune%20surveillance","dc:title":"immune surveillance"},{"@id":"https://cir.nii.ac.jp/all?q=mouse%20model","dc:title":"mouse model"},{"@id":"https://cir.nii.ac.jp/all?q=RC581-607","dc:title":"RC581-607"},{"@id":"https://cir.nii.ac.jp/all?q=B%20cell%20lymphoma","dc:title":"B cell lymphoma"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Transformation,%20Neoplastic","dc:title":"Cell Transformation, Neoplastic"},{"@id":"https://cir.nii.ac.jp/all?q=Epstein-Barr%20virus","dc:title":"Epstein-Barr virus"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Immunologic%20diseases.%20Allergy","dc:title":"Immunologic diseases. Allergy"},{"@id":"https://cir.nii.ac.jp/all?q=lymphoproliferative%20disease","dc:title":"lymphoproliferative disease"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781993346560","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H02669"},{"@type":"JGN","@value":"JP18H02669"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02669/"}],"notation":[{"@language":"ja","@value":"免疫特性と癌化に及ぼすリンパ球増殖限界制御の分子基盤"},{"@language":"en","@value":"Regulation of lymphocyte cell division and oncogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1040566775636685952","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K22538"},{"@type":"JGN","@value":"JP19K22538"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22538/"}],"notation":[{"@language":"ja","@value":"体細胞寿命および新旧細胞間相互作用の解析"},{"@language":"en","@value":"Whole-life tracing and cell-cell regulation in B cells"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144135696256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oncogenic Mechanisms in Burkitt Lymphoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011144472897280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation."}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146595057536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lymphoid Hyperplasia and Lymphoma in Transgenic Mice Expressing the Small Non-Coding RNA, EBER1 of Epstein-Barr Virus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620031550080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comprehensive Genomic Profiling of EBV-Positive Diffuse Large B-cell Lymphoma and the Expression and Clinicopathological Correlations of Some Related 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