{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360290617885027200.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/glycob/cwab015"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/glycob/advance-article-pdf/doi/10.1093/glycob/cwab015/37018325/cwab015.pdf"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/glycob/article-pdf/31/7/827/39610830/cwab015.pdf"}},{"identifier":{"@type":"PMID","@value":"33677516"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Intestinal lamina propria macrophages upregulate interleukin-10 mRNA in response to signals from commensal bacteria recognized by MGL1/CD301a"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Ligand-induced cellular signaling involved in interleukin 10 (IL-10) production by lamina propria macrophages (LPMs) during their interactions with commensal bacteria is not clearly understood. We previously showed, using mice lacking a C-type lectin MGL1/CD301a, that this molecule on colonic LPMs plays an important role in the induction of IL-10 upon interaction with commensal bacteria, Streptococcus sp.</jats:p><jats:p>In the present report, we show that the physical engagement of MGL1/CD301a on LPMs with in-situ isolated Streptococcus sp. bacteria leads to IL-10 messenger RNA (mRNA) induction. Spleen tyrosine kinase (Syk), caspase recruitment domain 9 (CARD9) and extracellular signal-regulated kinase (ERK), but not NF-κB pathway, are shown to be indispensable for IL-10 mRNA induction after stimulation with heat-killed Streptococcus sp. Guanidine hydrochloride treatment of Streptococcus sp., which is known to extract bacterial cell surface glycan-rich components, abolished bacterial binding to recombinant MGL1/CD301a. The extract contained materials which bound rMGL1 in ELISA and appeared to induce IL-10 mRNA expression in LPMs in vitro. Lectin blotting showed that the extract contained glycoproteins that are considered as putative ligands for MGL1. Some human commensal Lactobacillus species also induced IL-10 mRNA expression by colonic LPMs in vitro, which depends on the presence of MGL1/CD301a and CARD9. The present results are the first to show that MGL1/CD301a acts as a signal transducer during colonic host–microbe interactions.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380290617885027342","@type":"Researcher","foaf:name":[{"@value":"Ryosuke Kurashina"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326215888128","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00313122"},{"@type":"NRID","@value":"1000000313122"},{"@type":"NRID","@value":"9000004656876"},{"@type":"NRID","@value":"9000000419608"},{"@type":"NRID","@value":"9000283564133"},{"@type":"NRID","@value":"9000414258397"},{"@type":"NRID","@value":"9000257773310"},{"@type":"NRID","@value":"9000253179265"},{"@type":"NRID","@value":"9000283564530"},{"@type":"NRID","@value":"9000257774073"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0057225"}],"foaf:name":[{"@value":"Kaori Denda-Nagai"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"},{"@value":"Division of Glycobiologics, Intractable Disease Research Center, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617885027343","@type":"Researcher","foaf:name":[{"@value":"Kengo Saba"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617885027336","@type":"Researcher","foaf:name":[{"@value":"Tomoko Hisai"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617885027330","@type":"Researcher","foaf:name":[{"@value":"Hiromitsu Hara"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380290617885027338","@type":"Researcher","foaf:name":[{"@value":"Tatsuro Irimura"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan"},{"@value":"Division of Glycobiologics, Intractable Disease Research Center, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14602423"}],"prism:publicationName":[{"@value":"Glycobiology"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2021-02-23","prism:volume":"31","prism:number":"7","prism:startingPage":"827","prism:endingPage":"837"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by-nc/4.0/"],"url":[{"@id":"http://academic.oup.com/glycob/advance-article-pdf/doi/10.1093/glycob/cwab015/37018325/cwab015.pdf"},{"@id":"http://academic.oup.com/glycob/article-pdf/31/7/827/39610830/cwab015.pdf"}],"createdAt":"2021-02-20","modifiedAt":"2023-10-21","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Bacteria","dc:title":"Bacteria"},{"@id":"https://cir.nii.ac.jp/all?q=Macrophages","dc:title":"Macrophages"},{"@id":"https://cir.nii.ac.jp/all?q=Asialoglycoproteins","dc:title":"Asialoglycoproteins"},{"@id":"https://cir.nii.ac.jp/all?q=Membrane%20Proteins","dc:title":"Membrane 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