<i>Cryptococcus neoformans</i> var. <i>grubii</i> : Separate Varietal Status for <i>Cryptococcus neoformans</i> Serotype A Isolates

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  • Sarah P. Franzot
    <!--label omitted: 1-->Department of Pharmacology, Cornell University Medical College, New York,1
  • Ira F. Salkin
    <!--label omitted: 2-->Wadsworth Center, New York State Department of Health, Albany,2 and
  • Arturo Casadevall
    <!--label omitted: 3-->Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx,3 New York

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<jats:title>ABSTRACT</jats:title> <jats:p> <jats:italic>Cryptococcus neoformans</jats:italic> var. <jats:italic>neoformans</jats:italic> presently includes isolates which have been determined by the immunologic reactivity of their capsular polysaccharides to be serotype A and those which have been determined to be serotype D. However, recent analyses of the <jats:italic>URA5</jats:italic> sequences and DNA fingerprinting patterns suggest significant genetic differences between the two serotypes. Therefore, we propose to recognize these genotypic distinctions, as well as previously reported phenotypic differences, by restricting <jats:italic>C. neoformans</jats:italic> var. <jats:italic>neoformans</jats:italic> to isolates which are serotype D and describing a new variety, <jats:italic>C. neoformans</jats:italic> var. <jats:italic>grubii</jats:italic> , for serotype A isolates. </jats:p>

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