{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360292619589052544.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1155/2008/384010"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/archive/2008/384010.pdf"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/archive/2008/384010.xml"}}],"dc:title":[{"@value":"Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>A class of Ag(I) N-heterocyclic carbene silver complexes, <jats:bold>1</jats:bold>–<jats:bold>3</jats:bold>, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes <jats:bold>1</jats:bold>–<jats:bold>3</jats:bold> are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows <jats:bold>1</jats:bold> to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380292619589052548","@type":"Researcher","foaf:name":[{"@value":"Doug A. Medvetz"}],"jpcoar:affiliationName":[{"@value":"Knight Chemical Laboratory 105, Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292619589052547","@type":"Researcher","foaf:name":[{"@value":"Khadijah M. Hindi"}],"jpcoar:affiliationName":[{"@value":"Knight Chemical Laboratory 105, Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292619589052546","@type":"Researcher","foaf:name":[{"@value":"Matthew J. Panzner"}],"jpcoar:affiliationName":[{"@value":"Knight Chemical Laboratory 105, Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292619589052545","@type":"Researcher","foaf:name":[{"@value":"Andrew J. Ditto"}],"jpcoar:affiliationName":[{"@value":"Olsen Research Center 301D, Department of Biomedical Engineering, The University of Akron, Akron, OH 44325-0302, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292619589052544","@type":"Researcher","foaf:name":[{"@value":"Yang H. Yun"}],"jpcoar:affiliationName":[{"@value":"Olsen Research Center 301D, Department of Biomedical Engineering, The University of Akron, Akron, OH 44325-0302, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292619589052549","@type":"Researcher","foaf:name":[{"@value":"Wiley J. Youngs"}],"jpcoar:affiliationName":[{"@value":"Knight Chemical Laboratory 105, Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"07930291"},{"@type":"EISSN","@value":"16875486"}],"prism:publicationName":[{"@value":"Metal-Based Drugs"}],"dc:publisher":[{"@value":"Hindawi Limited"}],"prism:publicationDate":"2008-07-01","prism:volume":"2008","prism:startingPage":"1","prism:endingPage":"7"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/3.0/"],"url":[{"@id":"http://downloads.hindawi.com/archive/2008/384010.pdf"},{"@id":"http://downloads.hindawi.com/archive/2008/384010.xml"}],"createdAt":"2008-07-03","modifiedAt":"2020-12-08","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004233637841536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Blue-emitting acridine-tagged silver(<scp>i</scp>)-bis-N-heterocyclic carbene"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1155/2008/384010"},{"@type":"CROSSREF","@value":"10.1039/c9ra00281b_references_DOI_OjAt2Wy3F7YCpk2KApK2HU9FZHb"}]}