{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360292619698928640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/ajh.2009.270"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/ajh/article-pdf/23/4/368/6629720/23_4_368.pdf"}},{"identifier":{"@type":"PMID","@value":"20075849"}}],"dc:title":[{"@value":"Additive Beneficial Effects of Lactotripeptides Intake With Regular Exercise on Endothelium-Dependent Dilatation in Postmenopausal Women"}],"description":[{"notation":[{"@value":"Peripheral conduit artery endothelium-dependent dilatation decreases with aging in humans. Lactotripeptides (LTPs) and regular exercise can improve endothelium-dependent dilatation, but combining these lifestyle modifications may be more effective than either treatment alone. We conducted a randomized, place-controlled trial with four different intervention arms.A total of 43 postmenopausal women (50-65 years old) were randomly divided into placebo, LTP, exercise and placebo (Ex+placebo), or exercise and LTP (Ex+LTP) groups. LTP or placebo was administered orally for 8 weeks. The exercise groups completed an 8-week moderate aerobic exercise (walking or cycling) intervention.There were no statistically significant differences in baseline flow-mediated dilatation (FMD) and most other key dependent variables among the groups. FMD significantly increased in the LTP, Ex+placebo, and Ex+LTP groups whereas no such changes were observed in the placebo control group. The magnitude of increases in FMD was significantly greater in the Ex+LTP group than other intervention groups.We concluded that LTP ingestion combined with regular aerobic exercise improves endothelium-dependent dilatation to a greater extent than monotherapy with either intervention alone in postmenopausal women."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380292619698928642","@type":"Researcher","foaf:name":[{"@value":"M. Yoshizawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292619698928646","@type":"Researcher","foaf:name":[{"@value":"S. Maeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292619698928647","@type":"Researcher","foaf:name":[{"@value":"A. Miyaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292619698928644","@type":"Researcher","foaf:name":[{"@value":"M. Misono"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292619698928645","@type":"Researcher","foaf:name":[{"@value":"Y. Choi"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292619698928640","@type":"Researcher","foaf:name":[{"@value":"N. Shimojo"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292619698928643","@type":"Researcher","foaf:name":[{"@value":"R. Ajisaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292619698928641","@type":"Researcher","foaf:name":[{"@value":"H. Tanaka"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08957061"},{"@type":"EISSN","@value":"19417225"}],"prism:publicationName":[{"@value":"American Journal of Hypertension"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2010-04-01","prism:volume":"23","prism:number":"4","prism:startingPage":"368","prism:endingPage":"372"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://academic.oup.com/ajh/article-pdf/23/4/368/6629720/23_4_368.pdf"}],"createdAt":"2010-01-14","modifiedAt":"2025-02-16","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Endothelium-Dependent%20Relaxing%20Factors","dc:title":"Endothelium-Dependent Relaxing Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Dose-Response%20Relationship,%20Drug","dc:title":"Dose-Response Relationship, Drug"},{"@id":"https://cir.nii.ac.jp/all?q=Blood%20Pressure","dc:title":"Blood Pressure"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Combined%20Modality%20Therapy","dc:title":"Combined Modality Therapy"},{"@id":"https://cir.nii.ac.jp/all?q=Postmenopause","dc:title":"Postmenopause"},{"@id":"https://cir.nii.ac.jp/all?q=Vasodilation","dc:title":"Vasodilation"},{"@id":"https://cir.nii.ac.jp/all?q=Cardiovascular%20Diseases","dc:title":"Cardiovascular Diseases"},{"@id":"https://cir.nii.ac.jp/all?q=Dietary%20Supplements","dc:title":"Dietary Supplements"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Endothelium,%20Vascular","dc:title":"Endothelium, Vascular"},{"@id":"https://cir.nii.ac.jp/all?q=Exercise","dc:title":"Exercise"},{"@id":"https://cir.nii.ac.jp/all?q=Oligopeptides","dc:title":"Oligopeptides"},{"@id":"https://cir.nii.ac.jp/all?q=Blood%20Flow%20Velocity","dc:title":"Blood Flow Velocity"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004234516665984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Combined effects of lactotripeptide and aerobic exercise on cognitive function and cerebral oxygenation in middle-aged and older adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236341654912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Blood Flow Restricted Exercise and Vascular Function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657338767616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lactotripeptide ingestion increases cerebral blood flow velocity in middle-aged and older adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204671159552","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Habitual exercise decreases plasma xanthine oxidoreductase activity in middle-aged and older women"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001277367752448","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of Lactotripeptide Supplementation on Tele-Monitored Home Blood Pressure and on Vascular and Renal Function in Prehypertension　― Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study ―"}]},{"@id":"https://cir.nii.ac.jp/crid/1390005667264222208","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Possible renoprotective effect of lactotripeptides: A brief review"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681303228800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Rice Bran Extract Reduces the Risk of Atherosclerosis in Post-Menopausal Vietnamese Women"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/ajh.2009.270"},{"@type":"OPENAIRE","@value":"doi_dedup___::10ea983bd9ce9b3c34586f3df72cb2c3"},{"@type":"CROSSREF","@value":"10.1093/ajcn/nqy235_references_DOI_3mDV0tQJOPHpFRMS3T6xoBwD6UD"},{"@type":"CROSSREF","@value":"10.1155/2012/543218_references_DOI_3mDV0tQJOPHpFRMS3T6xoBwD6UD"},{"@type":"CROSSREF","@value":"10.1253/circrep.cr-19-0061_references_DOI_3mDV0tQJOPHpFRMS3T6xoBwD6UD"},{"@type":"CROSSREF","@value":"10.3164/jcbn.17-101_references_DOI_3mDV0tQJOPHpFRMS3T6xoBwD6UD"},{"@type":"CROSSREF","@value":"10.1016/j.nutres.2018.03.009_references_DOI_3mDV0tQJOPHpFRMS3T6xoBwD6UD"},{"@type":"CROSSREF","@value":"10.30548/vascfail.4.1_1_references_DOI_3mDV0tQJOPHpFRMS3T6xoBwD6UD"},{"@type":"CROSSREF","@value":"10.3177/jnsv.62.295_references_DOI_3mDV0tQJOPHpFRMS3T6xoBwD6UD"}]}