{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360292620007923968.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1177/154405910608500902"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/pdf/10.1177/154405910608500902"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/full-xml/10.1177/154405910608500902"}}],"dc:title":[{"@value":"Role of Macromolecular Assembly of Enamel Matrix Proteins in Enamel Formation"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> Unlike other mineralized tissues, mature dental enamel is primarily (> 95% by weight) composed of apatitic crystals and has a unique hierarchical structure. Due to its high mineral content and organized structure, enamel has exceptional functional properties and is the hardest substance in the human body. Enamel formation (amelogenesis) is the result of highly orchestrated extracellular processes that regulate the nucleation, growth, and organization of forming mineral crystals. However, major aspects of the mechanism of enamel formation are not well-understood, although substantial evidence suggests that protein-protein and protein-mineral interactions play crucial roles in this process. The purpose of this review is a critical evaluation of the present state of knowledge regarding the potential role of the assembly of enamel matrix proteins in the regulation of crystal growth and the structural organization of the resulting enamel tissue. This review primarily focuses on the structure and function of amelogenin, the predominant enamel matrix protein. This review also provides a brief description of novel in vitro approaches that have used synthetic macromolecules ( i.e., surfactants and polymers) to regulate the formation of hierarchical inorganic (composite) structures in a fashion analogous to that believed to take place in biological systems, such as enamel. Accordingly, this review illustrates the potential for developing bio-inspired approaches to mineralized tissue repair and regeneration. In conclusion, the authors present a hypothesis, based on the evidence presented, that the full-length amelogenin uniquely regulates proper enamel formation through a process of cooperative mineralization, and not as a pre-formed matrix. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004231507103372","@type":"Researcher","foaf:name":[{"@value":"H.C. Margolis"}],"jpcoar:affiliationName":[{"@value":"Department of Biomineralization, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA; and"},{"@value":"GlaxoSmithKline, Weybridge, Surrey, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620007923969","@type":"Researcher","foaf:name":[{"@value":"E. Beniash"}],"jpcoar:affiliationName":[{"@value":"Department of Biomineralization, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA; and"},{"@value":"GlaxoSmithKline, Weybridge, Surrey, UK"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620007923968","@type":"Researcher","foaf:name":[{"@value":"C.E. Fowler"}],"jpcoar:affiliationName":[{"@value":"Department of Biomineralization, The Forsyth Institute, 140 The Fenway, Boston, MA 02115, USA; and"},{"@value":"GlaxoSmithKline, Weybridge, Surrey, UK"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00220345"},{"@type":"EISSN","@value":"15440591"}],"prism:publicationName":[{"@value":"Journal of Dental Research"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"2006-09","prism:volume":"85","prism:number":"9","prism:startingPage":"775","prism:endingPage":"793"},"reviewed":"false","dc:rights":["https://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"https://journals.sagepub.com/doi/pdf/10.1177/154405910608500902"},{"@id":"https://journals.sagepub.com/doi/full-xml/10.1177/154405910608500902"}],"createdAt":"2009-01-09","modifiedAt":"2025-01-28","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004231507103488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structural and Morphometric Comparison of the Molar Teeth in Pre-eruptive Developmental Stage of PACAP-Deficient and Wild-Type Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232262394240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Physicochemical properties of artificial proteins that accelerate nucleation of crystalline calcium phosphate"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235496187392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Osteogain improves osteoblast adhesion, proliferation and differentiation on a bovine‐derived natural bone mineral"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236594509312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Amelogenins as Potential Buffers during Secretory-stage Amelogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710487910144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inhibition of hydroxyapatite growth by casein, a potential salivary phosphoprotein homologue"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170613908864","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Protein Phosphorylation and Mineral Binding Affect the Secondary Structure of the Leucine-Rich Amelogenin Peptide"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187537122816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Controlled Osteogenic Differentiation of Mouse Mesenchymal Stem Cells by Tetracycline-Controlled Transcriptional Activation of Amelogenin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643263866496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Twenty years of enamel matrix derivative: the past, the present and the future"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643767510272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Biomimetic Enamel Regeneration Mediated by Leucine-Rich Amelogenin Peptide"}]},{"@id":"https://cir.nii.ac.jp/crid/1360849943818381568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Trafficking and secretion of keratin 75 by ameloblasts in vivo"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1177/154405910608500902"},{"@type":"CROSSREF","@value":"10.1007/s12031-014-0392-6_references_DOI_JFum4w7TPAw4LX9RPItxHGqi721"},{"@type":"CROSSREF","@value":"10.1111/clr.12802_references_DOI_JFum4w7TPAw4LX9RPItxHGqi721"},{"@type":"CROSSREF","@value":"10.1177/0022034514564186_references_DOI_JFum4w7TPAw4LX9RPItxHGqi721"},{"@type":"CROSSREF","@value":"10.1111/eos.12196_references_DOI_JFum4w7TPAw4LX9RPItxHGqi721"},{"@type":"CROSSREF","@value":"10.3389/fphys.2017.00450_references_DOI_JFum4w7TPAw4LX9RPItxHGqi721"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0145677_references_DOI_JFum4w7TPAw4LX9RPItxHGqi721"},{"@type":"CROSSREF","@value":"10.1111/jcpe.12546_references_DOI_JFum4w7TPAw4LX9RPItxHGqi721"},{"@type":"CROSSREF","@value":"10.1177/0022034516688659_references_DOI_JFum4w7TPAw4LX9RPItxHGqi721"},{"@type":"CROSSREF","@value":"10.1074/jbc.ra119.010037_references_DOI_JFum4w7TPAw4LX9RPItxHGqi721"},{"@type":"CROSSREF","@value":"10.1016/j.jcrysgro.2010.10.167_references_DOI_JFum4w7TPAw4LX9RPItxHGqi721"}]}