{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360292620129670528.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1191/096120301682430195"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/pdf/10.1191/096120301682430195"}},{"identifier":{"@type":"PMID","@value":"11678449"}},{"identifier":{"@type":"NAID","@value":"30022434295"}}],"dc:title":[{"@value":"Antiribosomal P protein antibody in human systemic lupus erythematosus reacts                 specifically with activated T cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> We examined the presence of the epitope recognized by antiribosomal P protein antibody (anti-P) on the cell surface of human immunocompetent cells. Highly purified CD4/ and CD8/ T cells, and B cells from normal healthy individuals were reacted with affinity-purified IgG anti-P, and were stained with FITC-conjugated F(ab<jats:sup>0</jats:sup>)<jats:sub>2</jats:sub>, fragment goat anti-human IgG, followed by analysis on flow cytometry with gating for viable cells by propidium iodide staining. The presence of an epitope that is antigenically related to the carboxyl-terminal 22-amino-acid sequence of ribosomal P protein was not demonstrated on the surface of fresh CD4/ and CD8/ T cells, or fresh B cells. However, the expression of the ribosomal P epitope was induced on CD4/ and CD8/ T cells after activation with immobilized anti-CD3, whereas the epitope was not expressed on activated B cells. These results indicate that anti-P is an antilymphocyte antibody, which reacts specifically with activated T cells but not with resting T cells or B cells, suggesting possible direct effects of anti-P on the immune dysregulation in systemic lupus erythematosus. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1580291226464953088","@type":"Researcher","foaf:name":[{"@value":"S Hirohata"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620129670529","@type":"Researcher","foaf:name":[{"@value":"K Nakanishi"}],"jpcoar:affiliationName":[{"@value":"Department of Internal Medicine, Teikyo University School of Medicine,                         Tokyo, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09612033"},{"@type":"EISSN","@value":"14770962"}],"prism:publicationName":[{"@value":"Lupus"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"2001-09","prism:volume":"10","prism:number":"9","prism:startingPage":"612","prism:endingPage":"621"},"reviewed":"false","dc:rights":["https://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"https://journals.sagepub.com/doi/pdf/10.1191/096120301682430195"}],"createdAt":"2003-11-12","modifiedAt":"2025-03-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=CD4-Positive%20T-Lymphocytes","dc:title":"CD4-Positive T-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Ribosomal%20Proteins","dc:title":"Ribosomal Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=B-Lymphocytes","dc:title":"B-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Protozoan%20Proteins","dc:title":"Protozoan Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Antibodies,%20Monoclonal","dc:title":"Antibodies, Monoclonal"},{"@id":"https://cir.nii.ac.jp/all?q=CD8-Positive%20T-Lymphocytes","dc:title":"CD8-Positive T-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Flow%20Cytometry","dc:title":"Flow Cytometry"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphocyte%20Activation","dc:title":"Lymphocyte Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Epitopes","dc:title":"Epitopes"},{"@id":"https://cir.nii.ac.jp/all?q=Jurkat%20Cells","dc:title":"Jurkat Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Antibody%20Specificity","dc:title":"Antibody Specificity"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Lupus%20Erythematosus,%20Systemic","dc:title":"Lupus Erythematosus, Systemic"},{"@id":"https://cir.nii.ac.jp/all?q=Cells,%20Cultured","dc:title":"Cells, Cultured"},{"@id":"https://cir.nii.ac.jp/all?q=Autoantibodies","dc:title":"Autoantibodies"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285709230154496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Anti-ribosomal P protein antibodies influence mortality of patients with diffuse psychiatric/neuropsychological syndromes in systemic lupus erythematous involving a severe form of the disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204650002688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Central nervous system involvement in connective tissue diseases"},{"@language":"ja","@value":"こう原病の難治性病態　　中枢神経病変"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206446916096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"5. 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