{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360292620391069184.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/jbmr.36"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjbmr.36"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jbmr/article-pdf/25/7/1572/56578381/jbmr36.pdf"}}],"dc:title":[{"@value":"Pathway-based genome-wide association analysis identified the importance of regulation-of-autophagy pathway for ultradistal radius BMD"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>Wrist fracture is not only one of the most common osteoporotic fractures but also a predictor of future fractures at other sites. Wrist bone mineral density (BMD) is an important determinant of wrist fracture risk, with high heritability. Specific genes underlying wrist BMD variation are largely unknown. Most published genome-wide association studies (GWASs) have focused only on a few top-ranking single-nucleotide polymorphisms (SNPs)/genes and considered each of the identified SNPs/genes independently. To identify biologic pathways important to wrist BMD variation, we used a novel pathway-based analysis approach in our GWAS of wrist ultradistal radius (UD) BMD, examining approximately 500,000 SNPs genome-wide from 984 unrelated whites. A total of 963 biologic pathways/gene sets were analyzed. We identified the regulation-of-autophagy (ROA) pathway that achieved the most significant result (p = .005, qfdr = 0.043, pfwer = 0.016) for association with UD BMD. The ROA pathway also showed significant association with arm BMD in the Framingham Heart Study sample containing 2187 subjects, which further confirmed our findings in the discovery cohort. Earlier studies indicated that during endochondral ossification, autophagy occurs prior to apoptosis of hypertrophic chondrocytes, and it also has been shown that some genes in the ROA pathway (e.g., INFG) may play important roles in osteoblastogenesis or osteoclastogenesis. Our study supports the potential role of the ROA pathway in human wrist BMD variation and osteoporosis. Further functional evaluation of this pathway to determine the mechanism by which it regulates wrist BMD should be pursued to provide new insights into the pathogenesis of wrist osteoporosis. © 2010 American Society for Bone and Mineral Research</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380292620391069190","@type":"Researcher","foaf:name":[{"@value":"Lishu Zhang"}],"jpcoar:affiliationName":[{"@value":"Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri–Kansas City, Kansas City, MO, USA"},{"@value":"Institute of Bioscience and Biotechnology, School of Science, Beijing Jiaotong University, Beijing, People's Republic of China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069184","@type":"Researcher","foaf:name":[{"@value":"Yan-Fang Guo"}],"jpcoar:affiliationName":[{"@value":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China"},{"@value":"Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri–Kansas City, Kansas City, MO, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069313","@type":"Researcher","foaf:name":[{"@value":"Yao-Zhong Liu"}],"jpcoar:affiliationName":[{"@value":"Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri–Kansas City, Kansas City, MO, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069185","@type":"Researcher","foaf:name":[{"@value":"Yong-Jun Liu"}],"jpcoar:affiliationName":[{"@value":"Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri–Kansas City, Kansas City, MO, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069187","@type":"Researcher","foaf:name":[{"@value":"Dong-Hai Xiong"}],"jpcoar:affiliationName":[{"@value":"Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri–Kansas City, Kansas City, MO, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069316","@type":"Researcher","foaf:name":[{"@value":"Xiao-Gang Liu"}],"jpcoar:affiliationName":[{"@value":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069188","@type":"Researcher","foaf:name":[{"@value":"Liang Wang"}],"jpcoar:affiliationName":[{"@value":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069318","@type":"Researcher","foaf:name":[{"@value":"Tie-Lin Yang"}],"jpcoar:affiliationName":[{"@value":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069314","@type":"Researcher","foaf:name":[{"@value":"Shu-Feng Lei"}],"jpcoar:affiliationName":[{"@value":"Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri–Kansas City, Kansas City, MO, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069320","@type":"Researcher","foaf:name":[{"@value":"Yan Guo"}],"jpcoar:affiliationName":[{"@value":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069189","@type":"Researcher","foaf:name":[{"@value":"Han Yan"}],"jpcoar:affiliationName":[{"@value":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069317","@type":"Researcher","foaf:name":[{"@value":"Yu-Fang Pei"}],"jpcoar:affiliationName":[{"@value":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069312","@type":"Researcher","foaf:name":[{"@value":"Feng Zhang"}],"jpcoar:affiliationName":[{"@value":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069319","@type":"Researcher","foaf:name":[{"@value":"Christopher J Papasian"}],"jpcoar:affiliationName":[{"@value":"Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri–Kansas City, Kansas City, MO, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069186","@type":"Researcher","foaf:name":[{"@value":"Robert R Recker"}],"jpcoar:affiliationName":[{"@value":"Osteoporosis Research Center, Creighton University, Omaha, NE, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292620391069315","@type":"Researcher","foaf:name":[{"@value":"Hong-Wen Deng"}],"jpcoar:affiliationName":[{"@value":"The Key Laboratory of Biomedical Information Engineering, Ministry of Education and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, People's Republic of China"},{"@value":"Departments of Orthopedic Surgery and Basic Medical Sciences, University of Missouri–Kansas City, Kansas City, MO, USA"},{"@value":"Institute of Bioscience and Biotechnology, School of Science, Beijing Jiaotong University, Beijing, People's Republic of China"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08840431"},{"@type":"EISSN","@value":"15234681"}],"prism:publicationName":[{"@value":"Journal of Bone and Mineral Research"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2010-06-30","prism:volume":"25","prism:number":"7","prism:startingPage":"1572","prism:endingPage":"1580"},"reviewed":"false","dc:rights":["https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjbmr.36"},{"@id":"https://academic.oup.com/jbmr/article-pdf/25/7/1572/56578381/jbmr36.pdf"}],"createdAt":"2010-01-29","modifiedAt":"2024-03-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360013168822816896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Degradation of the NOTCH intracellular domain by elevated autophagy in osteoblasts promotes osteoblast differentiation and alleviates osteoporosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165841776896","@type":"Article","resourceType":"学術雑誌論文(journal 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