{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360292621548782848.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/jcm.41.1.304-309.2003"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/JCM.41.1.304-309.2003"}},{"identifier":{"@type":"NAID","@value":"30021103689"}}],"dc:title":[{"@value":"Performance of the APTIMA Combo 2 Assay for Detection of\n            <i>Chlamydia trachomatis</i>\n            and\n            <i>Neisseria gonorrhoeae</i>\n            in Female Urine and Endocervical Swab Specimens"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            The greater sensitivity of nucleic acid amplification tests (NAATs) for\n            <jats:italic>Chlamydia trachomatis</jats:italic>\n            and\n            <jats:italic>Neisseria gonorrhoeae</jats:italic>\n            permits the use of urine and other noninvasive specimens, which can increase the reach and decrease the costs of public health screening programs aimed at controlling these infections. This study evaluated the performance of the APTIMA Combo 2 assay, a multiplex assay based on the transcription-mediated amplification reaction, for the simultaneous detection of both pathogens in endocervical swab and urine specimens from females. Combo 2 assay results were compared with patient infected status, which were available by using other commercial NAATs. Sensitivity and specificity for\n            <jats:italic>C. trachomatis</jats:italic>\n            were 94.2 and 97.6%, respectively, in swabs and 94.7 and 98.9%, respectively, in first-catch urine (FCU). Sensitivity and specificity for\n            <jats:italic>N. gonorrhoeae</jats:italic>\n            were 99.2 and 98.7%, respectively, in swabs and 91.3 and 99.3%, respectively, in FCU. The assay reliably detected both infections in coinfected patients. The Combo 2 assay can be recommended for use with endocervical swab and urine specimens from females, especially for screening tests for asymptomatic women in sexually transmitted disease surveillance programs. This Food and Drug Administration-cleared assay can be a useful tool in efforts to reduce the prevalence and incidence of\n            <jats:italic>C. trachomatis</jats:italic>\n            and\n            <jats:italic>N. gonorrhoeae</jats:italic>\n            infections in sexually active women and to prevent their costly and serious sequelae.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380292621548782849","@type":"Researcher","foaf:name":[{"@value":"C. A. Gaydos"}],"jpcoar:affiliationName":[{"@value":"Johns Hopkins University, Baltimore"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292621548782848","@type":"Researcher","foaf:name":[{"@value":"T. C. Quinn"}],"jpcoar:affiliationName":[{"@value":"Johns Hopkins University, Baltimore"},{"@value":"National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292621548782851","@type":"Researcher","foaf:name":[{"@value":"D. Willis"}],"jpcoar:affiliationName":[{"@value":"Florida State Department of Health, Jacksonville, Florida"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292621548782854","@type":"Researcher","foaf:name":[{"@value":"A. Weissfeld"}],"jpcoar:affiliationName":[{"@value":"Microbiology Specialists Incorporated, Houston, Texas"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292621548782853","@type":"Researcher","foaf:name":[{"@value":"E. W. Hook"}],"jpcoar:affiliationName":[{"@value":"University of Alabama, Birmingham, Alabama"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292621548782850","@type":"Researcher","foaf:name":[{"@value":"D. H. Martin"}],"jpcoar:affiliationName":[{"@value":"Louisiana State University, New Orleans, Louisiana"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292621548782852","@type":"Researcher","foaf:name":[{"@value":"D. V. Ferrero"}],"jpcoar:affiliationName":[{"@value":"San Joaquin County Public Health Services, Stockton"}]},{"@id":"https://cir.nii.ac.jp/crid/1380292621548782720","@type":"Researcher","foaf:name":[{"@value":"J. Schachter"}],"jpcoar:affiliationName":[{"@value":"University of California, San Francisco, California"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00951137"},{"@type":"EISSN","@value":"1098660X"}],"prism:publicationName":[{"@value":"Journal of Clinical Microbiology"}],"dc:publisher":[{"@value":"American Society for Microbiology"}],"prism:publicationDate":"2003-01","prism:volume":"41","prism:number":"1","prism:startingPage":"304","prism:endingPage":"309"},"reviewed":"false","dc:rights":["https://journals.asm.org/non-commercial-tdm-license"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/JCM.41.1.304-309.2003"}],"createdAt":"2003-01-07","modifiedAt":"2022-03-05","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390572321594178432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prevalence of <i>Neisseria gonorrhoeae </i>in Western Iran"},{"@value":"Prevalence of Neisseria gonorrhoeae in Western Iran"}]},{"@id":"https://cir.nii.ac.jp/crid/1571135651235512064","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"男子初尿からの淋菌、Chlamydia trachomatis 検出における APTIMA Combo 2 とAMPLICOR STD-1の比較"},{"@language":"en","@value":"A comparison of the performance of the APTIMA Combo 2 assay with that of the AMPLICOR STD-1 assay in detecting Neisseria gonorrhoeae and Chlamydia trachomatis in first-void urine samples from males with urethral discharge"}]},{"@id":"https://cir.nii.ac.jp/crid/1572261550675426816","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evaluation of Seeplex^【○!R】 STD6 ACE Detection kit for the diagnosis of six bacterial sexually transmitted infections"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449985577216","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"Transcription-Mediated Amplification 法を用いたRNA増幅による Chlamydia trachomatis および Neisseria gonorrhoeae の同時検出 : 産婦人科および泌尿器科における臨床評価"},{"@language":"en","@value":"Simultaneous Detection of Chlamydia trachomatis and Neisseria gonorrhoeae on the Basis of RNA Amplification by the Method of Transcription-Mediated Amplification : Clinical Evaluation at the Department of Obstetrics and Gynecology and the Urology Department"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1128/jcm.41.1.304-309.2003"},{"@type":"CIA","@value":"30021103689"},{"@type":"CROSSREF","@value":"10.7883/yoken.jjid.2021.006_references_DOI_8y3Thb6HzcbkEU5pJOngxqjBktU"}]}