{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360294643790416640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/cancers13102379"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2072-6694/13/10/2379/pdf"}},{"identifier":{"@type":"PMID","@value":"34069132"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Fucoxanthin and Colorectal Cancer Prevention"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Colorectal cancer (CRC), which ranks among the top 10 most prevalent cancers, can obtain a good outcome with appropriate surgery and/or chemotherapy. However, the global numbers of both new cancer cases and death from CRC are expected to increase up to 2030. Diet-induced lifestyle modification is suggested to be effective in reducing the risk of human CRC; therefore, interventional studies using diets or diet-derived compounds have been conducted to explore the prevention of CRC. Fucoxanthin (Fx), a dietary carotenoid, is predominantly contained in edible brown algae, such as Undaria pinnatifida (wakame) and Himanthalia elongata (Sea spaghetti), which are consumed particularly frequently in Asian countries but also in some Western countries. Fx is responsible for a majority of the anticancer effects exerted by the lipophilic bioactive compounds in those algae. Interventional human trials have shown that Fx and brown algae mitigate certain risk factors for CRC; however, the direct mechanisms underlying the anti-CRC properties of Fx remain elusive. Fx and its deacetylated type “fucoxanthinol” (FxOH) have been reported to exert potential anticancer effects in preclinical cancer models through the suppression of many cancer-related signal pathways and the tumor microenvironment or alteration of the gut microbiota. We herein review the most recent studies on Fx as a potential candidate drug for CRC prevention.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326217192704","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10391195"},{"@type":"NRID","@value":"1000010391195"},{"@type":"NRID","@value":"9000004262032"},{"@type":"NRID","@value":"9000413360771"},{"@type":"NRID","@value":"9000016854750"},{"@type":"NRID","@value":"9000007040374"},{"@type":"NRID","@value":"9000415157770"},{"@type":"NRID","@value":"9000283423451"},{"@type":"NRID","@value":"9000014162632"},{"@type":"NRID","@value":"9000007050301"},{"@type":"NRID","@value":"9000391552648"},{"@type":"NRID","@value":"9000399343701"},{"@type":"NRID","@value":"9000283423283"},{"@type":"NRID","@value":"9000002103890"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/71931_1658429"}],"foaf:name":[{"@value":"Masaru Terasaki"}],"jpcoar:affiliationName":[{"@value":"School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, Japan"},{"@value":"Advanced Research Promotion Center, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294643790416647","@type":"Researcher","foaf:name":[{"@value":"Atsuhito Kubota"}],"jpcoar:affiliationName":[{"@value":"School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801193937152","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10414286"},{"@type":"NRID","@value":"1000010414286"},{"@type":"NRID","@value":"9000413360769"},{"@type":"NRID","@value":"9000345282373"},{"@type":"NRID","@value":"9000006884693"},{"@type":"NRID","@value":"9000391636368"},{"@type":"NRID","@value":"9000410757922"},{"@type":"NRID","@value":"9000316695823"},{"@type":"NRID","@value":"9000415157774"},{"@type":"NRID","@value":"9000020435201"},{"@type":"NRID","@value":"9000254160127"},{"@type":"NRID","@value":"9000000566442"},{"@type":"NRID","@value":"9000397706738"},{"@type":"NRID","@value":"9000350640298"},{"@type":"NRID","@value":"9000253163877"},{"@type":"NRID","@value":"9000415159936"},{"@type":"NRID","@value":"9000345267362"},{"@type":"NRID","@value":"9000016897141"},{"@type":"NRID","@value":"9000347140821"},{"@type":"NRID","@value":"9000255712256"},{"@type":"NRID","@value":"9000290129063"},{"@type":"NRID","@value":"9000022041903"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0079753"}],"foaf:name":[{"@value":"Hiroyuki Kojima"}],"jpcoar:affiliationName":[{"@value":"School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, Japan"},{"@value":"Advanced Research Promotion Center, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido 061-0293, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801201830528","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80507731"},{"@type":"NRID","@value":"1000080507731"},{"@type":"NRID","@value":"9000019005213"},{"@type":"NRID","@value":"9000411998286"},{"@type":"NRID","@value":"9000414237091"},{"@type":"NRID","@value":"9000408481175"},{"@type":"NRID","@value":"9000408480340"},{"@type":"NRID","@value":"9000404472173"},{"@type":"NRID","@value":"9000399796566"},{"@type":"NRID","@value":"9000399795357"},{"@type":"NRID","@value":"9000399795623"},{"@type":"NRID","@value":"9000363284740"},{"@type":"NRID","@value":"9000391552649"},{"@type":"NRID","@value":"9000258720592"},{"@type":"NRID","@value":"9000399343705"},{"@type":"NRID","@value":"9000283362314"},{"@type":"NRID","@value":"9000398380266"},{"@type":"NRID","@value":"9000404003745"},{"@type":"NRID","@value":"9000305638480"},{"@type":"NRID","@value":"9000021093224"},{"@type":"NRID","@value":"9000021038445"},{"@type":"NRID","@value":"9000402443556"},{"@type":"NRID","@value":"9000413567799"},{"@type":"NRID","@value":"9000413363038"},{"@type":"NRID","@value":"9000409334658"},{"@type":"NRID","@value":"9000399797290"},{"@type":"NRID","@value":"9000350640650"},{"@type":"NRID","@value":"9000283250476"},{"@type":"NRID","@value":"9000413909873"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/hayato-maeda"}],"foaf:name":[{"@value":"Hayato Maeda"}],"jpcoar:affiliationName":[{"@value":"Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki, Aomori 036-8561, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294643790416646","@type":"Researcher","foaf:name":[{"@value":"Kazuo Miyashita"}],"jpcoar:affiliationName":[{"@value":"Center for Industry-University Collaboration, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294643790416642","@type":"Researcher","foaf:name":[{"@value":"Chikara Kawagoe"}],"jpcoar:affiliationName":[{"@value":"Algatech Kyowa, Kyowa Concrete Industry Co. Ltd., Hakodate, Hokkaido 040-0051, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294643790416644","@type":"Researcher","foaf:name":[{"@value":"Takuji Tanaka"}],"jpcoar:affiliationName":[{"@value":"Department of Diagnostic Pathology and Research Center of Diagnostic Pathology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu 500-8513, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294643790416641","@type":"Researcher","foaf:name":[{"@value":"Michihiro Mutoh"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular-Targeting Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-856, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20726694"}],"prism:publicationName":[{"@value":"Cancers"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2021-05-14","prism:volume":"13","prism:number":"10","prism:startingPage":"2379"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/2072-6694/13/10/2379/pdf"}],"createdAt":"2021-05-14","modifiedAt":"2025-10-11","project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256996990464","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K10611"},{"@type":"JGN","@value":"JP19K10611"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K10611/"}],"notation":[{"@language":"ja","@value":"マイクロプラスチック由来化学物質の核内受容体を介した制御性Ｔ細胞応答への影響"},{"@language":"en","@value":"Effects of microplastic-derived chemicals on functions of regulatory T cells via nuclear receptor Nr4a."}]},{"@id":"https://cir.nii.ac.jp/crid/1040285300694518144","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20H00627"},{"@type":"JGN","@value":"JP20H00627"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00627/"}],"notation":[{"@language":"ja","@value":"フェノール系内分泌攪乱化学物質の都市水域への負荷源解析、動態把握、歴史変遷の解明"},{"@language":"en","@value":"Sources and behaviors of broad-spectrum phenolic endocrine distrusting chemicals (EDCs) and historical trends of their pollution"}]},{"@id":"https://cir.nii.ac.jp/crid/1040566775676958592","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20K05879"},{"@type":"JGN","@value":"JP20K05879"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K05879/"}],"notation":[{"@language":"ja","@value":"フコキサンチンによる膵臓腫瘍微小環境抑制の分子Network制御機構の解明"},{"@language":"en","@value":"Elucidation of molecular network-regulating mechanisms on pancreatic tumor microenvironment suppression by fucoxanthin"}]},{"@id":"https://cir.nii.ac.jp/crid/1040569382213726720","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21H04843"},{"@type":"JGN","@value":"JP21H04843"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04843/"}],"notation":[{"@language":"ja","@value":"環境化学物質曝露による有害作用：ヒト疫学研究と動物実験による機序解明"},{"@language":"en","@value":"Adverse health effects of environmental chemical exposure: elucidation of mechanisms via human and animal studies"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050025031474688512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Nutraceutical characteristics of the brown seaweed carotenoid fucoxanthin"}]},{"@id":"https://cir.nii.ac.jp/crid/1050575520348369280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1050856970556364160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Alteration of fecal microbiota by fucoxanthin results in prevention of colorectal cancer in AOM/DSS mice"},{"@value":"Alteration of fecal microbiota by fucoxanthin results in prevention of colorectal cancer in AOM/DSS-treated mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1050869003310596096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ishimozuku (Sphaerotrichia firma) lipids containing fucoxanthin suppress fatty liver and improve short chain fatty acid production in obese model mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002217306605440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Carotenoid Profile of Edible Japanese Seaweeds: An Improved HPLC Method for Separation of Major Carotenoids"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142497229440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143585508224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143909120000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gut microbiota imbalance and colorectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143922727040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011143975604992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adipokines – removing road blocks to obesity and diabetes therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145209427200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Production, Characterization, and Antioxidant Activity of Fucoxanthin from the Marine Diatom Odontella aurita"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145725928192","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The gut microbiota and colon cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145779201792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of Fucoxanthin Addition to Ground Chicken Breast Meat on Lipid and Colour Stability during Chilled Storage, before and after Cooking"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146329971584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gut Microbiota, Inflammation, and Colorectal Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146527760128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antiobesity Effects of\n                    <i>Undaria</i>\n                    Lipid Capsules Prepared with Scallop Phospholipids"}]},{"@id":"https://cir.nii.ac.jp/crid/1360019689971905408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Variation of bioactive compounds in dried seaweed<i>Himanthalia elongata</i>subjected to different culinary processes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360019690555948928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Scientific Approaches on Extraction, Purification and Stability for the Commercialization of Fucoxanthin Recovered from Brown Algae"}]},{"@id":"https://cir.nii.ac.jp/crid/1360019690595897344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Associations among dietary seaweed intake, c-MYC rs6983267 polymorphism, and risk of colorectal cancer in a Korean population: a case–control study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360019690596054784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin Isolated from Undaria pinnatifida Can Interact with Escherichia coli and lactobacilli in the Intestine and Inhibit the Growth of Pathogenic Bacteria"}]},{"@id":"https://cir.nii.ac.jp/crid/1360019690748268928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antioxidant effects of fermented sea tangle (Laminaria japonica) by Lactobacillus brevis BJ20 in individuals with high level of γ-GT: A randomized, double-blind, and placebo-controlled clinical study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360019691976180352","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin—An Antibacterial Carotenoid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021391877752832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Anticancer Effects of Fucoxanthin in a PDX Model of Advanced Stage Pancreatic Cancer with Alteration of Several Multifunctional Molecules"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691092684160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285705260588288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>In Vitro</i> Cytotoxic Effect of Ethanol Extract Prepared From Sporophyll of <i>Undaria pinnatifida</i> on Human Colorectal Cancer Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292617911098624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hallmarks of Cancer: The Next Generation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618479333504","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Diabetes Mellitus and Risk of Colorectal Cancer: A Meta-Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618551383424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The relationship between 8-oxo-7,8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292618887132672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619113046016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619378240000","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cancer prevention by carotenoids"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619409860608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292619904094080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Radical Scavenging and Singlet Oxygen Quenching Activity of Marine Carotenoid Fucoxanthin and Its Metabolites"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620010263680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effective extraction of carotenoids from brown seaweeds and vegetable leaves with edible oils"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620146114048","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Pharmacokinetics of fucoxanthinol in human plasma after the oral administration of kombu extract"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620837530880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cancers Complicating Inflammatory Bowel Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621211458432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Obesity‐induced inflammation: a metabolic dialogue in the language of inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621245788800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of Undaria pinnatifida (Wakame) on Postprandial Glycemia and Insulin Levels in Humans: a Randomized Crossover Trial"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621466521600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294646583400576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Skin Irritation Testing beyond Tissue Viability: Fucoxanthin Effects on Inflammation, Homeostasis, and Metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298342484974720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Edible Brown Seaweed Sargassum horneri (Turner) C. Agardh Ameliorates High-Fat Diet-Induced Obesity, Diabetes, and Hepatic Steatosis in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757192707840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthinol Promotes Apoptosis in MCF-7 and MDA-MB-231 Cells by Attenuating Laminins–Integrins Axis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298759897771520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dendritic cell defects in the colorectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298761617958528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"An assessment of the techno-functional and sensory properties of yoghurt fortified with a lipid extract from the microalga Pavlova lutheri"}]},{"@id":"https://cir.nii.ac.jp/crid/1360301162539642880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of daily intake of Harudori-kombu: A randomized, double-blind, placebo-controlled, parallel-group study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360301162575481472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Impact of a (poly)phenol-rich extract from the brown algae Ascophyllum nodosum on DNA damage and antioxidant activity in an overweight or obese population: a randomized controlled trial"}]},{"@id":"https://cir.nii.ac.jp/crid/1360301163001700480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Recent progress in Lynch syndrome and other familial colorectal cancer syndromes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360301164318575360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anti-inflammatory effect of fucoxanthin on dextran sulfate sodium-induced colitis in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360301165455005824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comprehensive analysis of lncRNA-associated ceRNA network in colorectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360301165525209984","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Role of Oxidative Stress and Its Counteractive Utility in Colorectal Cancer (CRC)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360301165725961088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antioxidant, anti-inflammatory, and antiproliferative activities of organic fractions from the Mediterranean brown seaweed <i>Cystoseira sedoides</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360301166083475968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prolonged administration of Ascophyllum nodosum to healthy human volunteers and cardiovascular risk"}]},{"@id":"https://cir.nii.ac.jp/crid/1360301166615072384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of dietary <i>laminaria angustata</i> (brown seaweed) on azoxymethane‐induced intestinal carcinogenesis in male F344 rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360301167350720256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Lipids, Fatty Acids, and Fucoxanthin Content from Temperate and Tropical Brown Seaweeds"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568619123895552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dietary Fucoxanthin Induces Anoikis in Colorectal Adenocarcinoma by Suppressing Integrin Signaling in a Murine Colorectal Cancer Model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092449095296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin Prevents Colorectal Cancer Development in Dextran Sodium Sulfate-treated<i>Apc</i><sup>Min/+</sup>Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092709087616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of CLIC4 on Fucoxanthinol-Induced Apoptosis in Human Colorectal Cancer Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574092893709824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Comprehensive molecular characterization of human colon and rectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574093495538816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Live Free or Die"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094243901440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094857611264","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095186516096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Petalonia binghamiae Extract and Its Constituent Fucoxanthin Ameliorate High-Fat Diet-Induced Obesity by Activating AMP-Activated Protein Kinase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580235831129856","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Modulation of Gut Microbiota by Fucoxanthin During Alleviation of Obesity in High-Fat Diet-Fed Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580239715527936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Protective Effects of <i>Turbinaria ornata</i>\n and <i>Padina pavonia</i>\n against Azoxymethane-Induced Colon Carcinogenesis through Modulation of PPAR Gamma, NF-κB and Oxidative Stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360582641412142080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Optimisation of fucoxanthin extraction from Irish seaweeds by response surface methodology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360582642121889024","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of apoptosis by the tropical seaweed Pylaiella littoralis in HT-29 cells via the mitochondrial and MAPK pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1360582642223404160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prognostic Factors Involved in the Epithelial–Mesenchymal Transition Process in Colorectal Cancer Have a Preponderant Role in Oxidative Stress: A Systematic Review and Meta-Analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360582642257341824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin enhances 5-FU chemotherapeutic efficacy in colorectal cancer cells by affecting MMP-9 invasive proteins"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641450760704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reduction of HbA1c levels by fucoxanthin-enriched akamoku oil possibly involves the thrifty allele of uncoupling protein 1 (<i>UCP1</i>): a randomised controlled trial in normal-weight and obese Japanese adults"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656417316736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Down‐Regulation of Hepatic Stearoyl‐CoA Desaturase‐1 Expression by Fucoxanthin via Leptin Signaling in Diabetic/Obese KK‐<i>A</i><sup><i>y</i></sup> Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657232979328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin potentiates anoikis in colon mucosa and prevents carcinogenesis in AOM/DSS model mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848663498048128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Salivary Glycine Is a Significant Predictor for the Attenuation of Polyp and Tumor Microenvironment Formation by Fucoxanthin in AOM/DSS Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567686268416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Continuity of Tumor Microenvironmental Suppression in AOM/DSS Mice by Fucoxanthin May Be Able to Track With Salivary Glycine"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569478572800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dietary Combination of Fucoxanthin and Fish Oil Attenuates the Weight Gain of White Adipose Tissue and Decreases Blood Glucose in Obese/Diabetic KK-<i>A<sup>y</sup></i> Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570767148800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin modulates cecal and fecal microbiota differently based on diet"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593693641600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin Prevents Pancreatic Tumorigenesis in C57BL/6J Mice That Received Allogenic and Orthotopic Transplants of Cancer Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861704780341248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Biscuit Containing Fucoxanthin Prevents Colorectal Carcinogenesis in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360864113124528640","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of dietary fucoxanthin from Himanthalia elongata brown seaweed"}]},{"@id":"https://cir.nii.ac.jp/crid/1360864116098548992","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Seasonal variation of total lipid, fatty acids, fucoxanthin content, and antioxidant properties of two tropical brown algae (Nizamuddinia zanardinii and Cystoseira indica) from Iran"}]},{"@id":"https://cir.nii.ac.jp/crid/1360864116242062848","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dictyopteris undulata extract induces apoptosis in human colon cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360864117078544256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Dictyopteris undulata Extract Induces Apoptosis via Induction of Endoplasmic Reticulum Stress in Human Colon Cancer Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360864424758979584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Possible Biomarkers in Blood for Crohn’s Disease: Oxidative Stress and MicroRNAs—Current Evidences and Further Aspects to Unravel"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137043592465408","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anti-obesity property of the brown seaweed, Sargassum polycystum using an in vivo animal model"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045063696896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"K-ras Mutations as the Earliest Driving Force in a Subset of Colorectal Carcinomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137045255563136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat Model"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046517812480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High fucoxanthin wakame (Undaria pinnatifida) prevents tumor microenvironment formation in an AOM/DSS mouse carcinogenic model"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418518985183232","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anticancer effects of fucoxanthin and fucoxanthinol on colorectal cancer cell lines and colorectal cancer tissues"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519321678080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biological Properties of Fucoxanthin in Oil Recovered from  Two Brown Seaweeds Using Supercritical CO2 Extraction"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519565012096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammation and metabolic disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519598410112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519966509056","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cancer Genome Landscapes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520551470720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammatory mediators of pain"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993428200704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699993984364544","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"High oxygen radical production in patients with sporadic colorectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994541124480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Keto-Carotenoids Are the Major Metabolites of Dietary Lutein and Fucoxanthin in Mouse Tissues1–3"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699996226799360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975845328091136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Associations of Japanese food intake with survival of stomach and colorectal cancer: A prospective patient cohort study"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468746750976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Signaling in Innate Immunity and Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470198328320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin and Its Metabolites in Edible Brown Algae Cultivated in Deep Seawater"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981471325977344","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Development, Quantification, Method Validation, and Stability Study of a Novel Fucoxanthin-Fortified Milk"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944736222080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944739698560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of Anoikis in Human Colorectal Cancer Cells by Fucoxanthinol"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944893848576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Hereditary and Familial Colon Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946101011200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The effects of Xanthigen\n                    <sup>™</sup>\n                    in the weight management of obese premenopausal women with non‐alcoholic fatty liver disease and normal liver fat"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946185774976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immune Regulation of Metabolic Homeostasis in Health and Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946197615488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The risk of colorectal cancer in ulcerative colitis: a meta-analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418907000320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Low bioavailability of dietary epoxyxanthophylls in humans"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419184520704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Role of anti-inflammatory adipokines in obesity-related diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544419575864448","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Wnt/β-catenin pathway regulates growth and maintenance of colonospheres"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420695179520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phenotypic characterization of human colorectal cancer stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420745946240","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anticancer effects of seaweed compounds fucoxanthin and phloroglucinol, alone and in combination with 5-fluorouracil in colon cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420783574784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptional control of brown adipocyte development and physiological function—of mice and men"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825894064879488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Obesity—time to wake up"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895398557696","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Concerted down-regulation of immune-system related genes predicts metastasis in colorectal carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895429310464","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825895668630016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896005073536","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Brown and beige fat: development, function and therapeutic potential"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369205920384","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Seaweed Fucoxanthin Supplementation Improves Obesity Parameters in Mild Obese Japanese Subjects"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369700091136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Algae displaying the diadinoxanthin cycle also possess the violaxanthin cycle"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369990033920","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin production by heterokont microalgae"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370000258432","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inflammatory pathways in the early steps of colorectal cancer development"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370105392896","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin content and antioxidant properties of Undaria pinnatifida"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370719691776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"EVALUATION OF RECOVERABLE FUNCTIONAL LIPID COMPONENTS OF SEVERAL BROWN SEAWEEDS (PHAEOPHYTA) FROM JAPAN WITH SPECIAL REFERENCE TO FUCOXANTHIN AND FUCOSTEROL CONTENTS<sup>1</sup>"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107370989196928","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Diet, microorganisms and their metabolites, and colon cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843213469824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anti‐obese property of fucoxanthin is partly mediated by altering lipid‐regulating enzymes and uncoupling proteins of visceral adipose tissue in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843595727616","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Transcriptome Profiling of the Cancer, Adjacent Non-Tumor and Distant Normal Tissues from a Colorectal Cancer Patient by Deep Sequencing"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843653534208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The colorectal adenoma–carcinoma sequence"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844172155008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Marine Algae as a Potential Source for Anti-Obesity Agents"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844744162304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844746423296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of <i>Undaria pinnatifida</i> (Wakame) on the development of cerebrovascular diseases in stroke‐prone spontaneously hypertensive rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845045671168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A genetic model for colorectal tumorigenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845263449472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Adipokines in inflammation and metabolic disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845380344704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845732467968","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Microenvironmental regulation of stem cells in intestinal homeostasis and cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845806241152","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-A mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318888290176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin‐rich seaweed extract suppresses body weight gain and improves lipid metabolism in high‐fat‐fed C57BL/6J mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318914420864","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The metabolic syndrome and adipocytokines"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319483742208","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Immunohistochemical expression of 8-oxo-7,8-dihydro-2′-deoxyguanosine in cytoplasm of tumour and adjacent normal mucosa cells in patients with colorectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319998863360","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Beneficial effects of Undaria pinnatifida ethanol extract on diet-induced-insulin resistance in C57BL/6J mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320178251904","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320388511488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Epithelial-to-mesenchymal transition and the cancer stem cell phenotype: insights from cancer biology with therapeutic implications for colorectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320874130816","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Molecular Genetics of Colorectal Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320947457664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Anoikis molecular pathways and its role in cancer progression"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320954938496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARγ ligand, troglitazone, on colon cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951793466986880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Global patterns and trends in colorectal cancer incidence and mortality"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795517185280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Seasonal Patterns in the Photosynthetic Capacity, Tissue Pigment and Nutrient Content of Different Developmental Stages of Undaria pinnatifida (Phaeophyta: Laminariales) in Port Phillip Bay, South-Eastern Australia"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951795907022976","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxidative Stress Is Inherent in Prostate Cancer Cells and Is Required for Aggressive Phenotype"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951796297510016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268316910720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268372741248","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Brown Macroalgae as Valuable Food Ingredients"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268683458560","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antiangiogenic Activity of Brown Algae Fucoxanthin and Its Deacetylated Product, Fucoxanthinol"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233268878589184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cancer risk in patients with inflammatory bowel disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270695581184","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735081345","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin as a major carotenoid in Isochrysis aff"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735081347","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Extraction, purification and study on antioxidant properties of fucoxanthin from brown seaweeds"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735081483","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of Undaria pinnatifida and Laminaria japonica on rat’s intestinal microbiota and metabolite"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735081487","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of formation of azoxymethane-induced colonic aberrant crypt foci in rats by edible green algae Capsosiphon fulvescens and brown algae Hizikia fusiforme"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735081493","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tocopherol content of Japanese algae and its seasonal variation"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735081601","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antioxidant and anti-inflammatory effects of Padina pavonia and Turbenaria ornate in streptozotocin/nicotinamide diabetic rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735081618","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fucoxanthin-rich brown algae extract decreases inflammation and attenuates colitis-associated colon cancer in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735081861","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effects of a snack enriched with carob and Undaria pinnatifida (wakame) on metabolic parameters in a double blind, randomized clinical trial in obese patient"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735081986","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glycine and succinic acid are effective indicators of the suppression of epithelial-mesenchymal transition by fucoxanthinol in colorectal cancer stem-like cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735081987","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Production of fucoxanthin-rich powder from Cladosiphon okamuranus"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735081989","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Glycine is a predictor for a suppressive effect of fucoxanthinol on colonosphere formation under hypoxia"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735081991","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Study of microwave synergistic enzyme method for extraction from Laminaria Japonica by response surface methodology"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735081993","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Isolation of fucoxanthin and fatty acids analysis of Padina australis and cytotoxic effect of fucoxanthin on human lung cancer (H1299) cell lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735082112","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cellular redox status regulates hypoxia inducible factor-1 activity. Role in tumour development"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735082115","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antioxidant enzyme levels in cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735082128","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Could dietary seaweed reverse the metabolic syndrome?"}]},{"@id":"https://cir.nii.ac.jp/crid/1370864109735082137","@type":"Product","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Production of large amounts of hydrogen peroxide by human tumor cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204226219392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Single and 13-Week Oral Toxicity Study of Fucoxanthin Oil from Microalgae in Rats"},{"@language":"ja","@value":"微細藻類由来フコキサンチンオイルのラットを用いた単回投与毒性試験および１３週間反復経口投与毒性試験"},{"@language":"ja-Kana","@value":"ビサイ ソウルイ ユライ フコキサンチンオイル ノ ラット オ モチイタ タンカイ トウヨ ドクセイ シケン オヨビ 13シュウカン ハンプク ケイコウ トウヨ ドクセイ シケン"},{"@value":"Single and 13-week oral toxicity of fucoxanthin oil from microalgae in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204238622080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Case-Control Study of Colorectal Cancer and Its Relation to Diet, Cigarettes, and Alcohol Consumption in Saitama Prefecture, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204671040000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A marine bio-functional lipid, fucoxanthinol, attenuates human colorectal cancer stem-like cell tumorigenicity and sphere formation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204900223872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Single and repeated oral dose toxicity study of fucoxanthin (FX), a marine carotenoid, in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390012235938633728","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Symposium 6 “Researches for cancer prevention and future development”"},{"@language":"ja","@value":"シンポジウム6『がん予防研究と今後の展開』の企画報告"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679068753280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of Medium-chain Triacylglycerols on Anti-obesity Effect of Fucoxanthin"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679219843584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of the intake of <i>Undaria pinnatifida </i>(Wakame) and its <i>sporophylls </i>(Mekabu) on postprandial glucose and insulin metabolism"},{"@value":"Effects of the intake of Undaria pinnatifida (Wakame) and its sporophylls (Mekabu) on postprandial glucose and insulin metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679431662080","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Commercial-scale Preparation of Biofunctional Fucoxanthin from Waste Parts of Brown Sea Algae Laminalia japonica"},{"@value":"Commercial scale preparation of biofunctional fucoxanthin from waste parts of brown sea algae Laminaria japonica"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679435193088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Stability of Fucoxanthin in Dried <i>Undaria Pinnatifida</i> (Wakame) and Baked Products (Scones) Containing Wakame Powder"},{"@value":"Stability of Fucoxanthin in Dried Undaria Pinnatifida (Wakame) and Baked Products (Scones) Containing Wakame Powder"},{"@value":"Stability of fucoxanthin in dried Undaria pinnatifida (Wakame) and baked products (scone) containing Wakame powder"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679436513280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Fucoxanthin Extractions of Brown Seaweeds and Analysis of Their Lipid Fraction in Methanol"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679649953280","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Japanese Kelp (Kombu) Extract Suppressed the Formation of Aberrant Crypt Foci in Azoxymethane Challenged Mouse Colon"},{"@value":"Japanese kelp (kombu) extracts suppressed the formation of aberrant crypt foci in azoxymethane challenged mouse colon"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564238059753600","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with an anti-tumor predictor of glycine"},{"@value":"Fucoxanthin administration delays occurrence of tumors in xenograft mice by colonospheres, with and anti-tumor predictor of glycine"}]},{"@id":"https://cir.nii.ac.jp/crid/1390566775131430784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Possible Involvement of Lipids in the Effectiveness of Kombu in Individuals with Abnormally High Serum Triglyceride Levels"}]},{"@id":"https://cir.nii.ac.jp/crid/1390846609785797120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Pilot Study: Effects of Kombu Intake on Lifestyle-related Diseases -Possibility that Kombu Intake is Effective in Individuals with Abnormally High Serum Triglyceride Levels-"},{"@value":"A pilot study: Effects of kombu intake on lifestyle-related diseases-possibility that kombu intake is effective in individuals with abnormally high serum triacylglycerol levels"}]},{"@id":"https://cir.nii.ac.jp/crid/1390858209198255616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Antioxidative Activities of Plants and Fungi Used as Herbal Medicines"}]},{"@id":"https://cir.nii.ac.jp/crid/2051433317020842112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inhibition of NF-kappaB transcriptional activity enhances fucoxanthinol-induced apoptosis in colorectal cancer cells"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3390/cancers13102379"},{"@type":"KAKEN","@value":"PRODUCT-23695303"},{"@type":"KAKEN","@value":"PRODUCT-23837546"},{"@type":"KAKEN","@value":"PRODUCT-23841811"},{"@type":"KAKEN","@value":"PRODUCT-23990947"},{"@type":"OPENAIRE","@value":"doi_dedup___::c6070f08afa94acef8cdc0db419686f6"},{"@type":"CROSSREF","@value":"10.3390/onco3040016_references_DOI_K04UUe576fTDKFAxXioWRr66yPl"},{"@type":"CROSSREF","@value":"10.3390/onco2030010_references_DOI_K04UUe576fTDKFAxXioWRr66yPl"},{"@type":"CROSSREF","@value":"10.2198/electroph.66.63_references_DOI_K04UUe576fTDKFAxXioWRr66yPl"},{"@type":"CROSSREF","@value":"10.3389/fsufs.2023.1331061_references_DOI_K04UUe576fTDKFAxXioWRr66yPl"},{"@type":"CROSSREF","@value":"10.3390/ijms222413620_references_DOI_K04UUe576fTDKFAxXioWRr66yPl"},{"@type":"CROSSREF","@value":"10.3177/jnsv.69.76_references_DOI_K04UUe576fTDKFAxXioWRr66yPl"},{"@type":"CROSSREF","@value":"10.1080/01635581.2022.2086703_references_DOI_K04UUe576fTDKFAxXioWRr66yPl"}]}