{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360294646711448704.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2215/cjn.04290417"}},{"identifier":{"@type":"URI","@value":"https://journals.lww.com/01277230-201801000-00013"}}],"dc:title":[{"@value":"Predicting Outcome in Patients with Anti-GBM Glomerulonephritis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n            <jats:title>Background and objectives</jats:title>\n            <jats:p>Large studies on long-term kidney outcome in patients with anti-glomerular basement membrane (anti-GBM) GN are lacking. This study aimed to identify clinical and histopathologic parameters that predict kidney outcome in these patients.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Design, setting, participants, & measurements</jats:title>\n            <jats:p>This retrospective analysis included a total of 123 patients with anti-GBM GN between 1986 and 2015 from six centers worldwide. Their kidney biopsy samples were classified according to the histopathologic classification for ANCA-associated GN. Clinical data such as details of treatment were retrieved from clinical records. The primary outcome parameter was the occurrence of ESRD. Kidney survival was analyzed using the log-rank test and Cox regression analyses.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Results</jats:title>\n            <jats:p>The 5-year kidney survival rate was 34%, with an improved rate observed among patients diagnosed after 2007 (<jats:italic toggle=\"yes\">P</jats:italic>=0.01). In patients with anti-GBM GN, histopathologic class and kidney survival were associated (<jats:italic toggle=\"yes\">P</jats:italic><0.001). Only one of 15 patients with a focal class biopsy sample (≥50% normal glomeruli) developed ESRD. Patients with a sclerotic class biopsy sample (≥50% globally sclerotic glomeruli) and patients with 100% cellular crescents did not recover from dialysis dependency at presentation. In multivariable analysis, dialysis dependency at presentation (hazard ratio [HR], 3.17; 95% confidence interval [95% CI], 1.59 to 6.32), percentage of normal glomeruli (HR, 0.97; 95% CI, 0.95 to 0.99), and extent of interstitial infiltrate (HR, 2.02; 95% CI, 1.17 to 3.50) were predictors of ESRD during follow-up.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions</jats:title>\n            <jats:p>Dialysis dependency, low percentage of normal glomeruli, and large extent of interstitial infiltrate are associated with poor kidney outcome in anti-GBM GN. Kidney outcome has improved during recent years; the success rate doubled after 2007.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Podcast</jats:title>\n            <jats:p>This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2017_11_21_CJASNPodcast_18_1_v.mp3\n                              </jats:p>\n          </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380294646711448704","@type":"Researcher","foaf:name":[{"@value":"Emma E. van Daalen"}],"jpcoar:affiliationName":[{"@value":"Pathology and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448716","@type":"Researcher","foaf:name":[{"@value":"J. Charles Jennette"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Laboratory Medicine and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448712","@type":"Researcher","foaf:name":[{"@value":"Stephen P. McAdoo"}],"jpcoar:affiliationName":[{"@value":"Renal and Vascular Inflammation Section, Department of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448711","@type":"Researcher","foaf:name":[{"@value":"Charles D. Pusey"}],"jpcoar:affiliationName":[{"@value":"Renal and Vascular Inflammation Section, Department of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448705","@type":"Researcher","foaf:name":[{"@value":"Marco A. Alba"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Laboratory Medicine and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448706","@type":"Researcher","foaf:name":[{"@value":"Caroline J. Poulton"}],"jpcoar:affiliationName":[{"@value":"Kidney Center, Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448718","@type":"Researcher","foaf:name":[{"@value":"Ron Wolterbeek"}],"jpcoar:affiliationName":[{"@value":"Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448707","@type":"Researcher","foaf:name":[{"@value":"Tri Q. Nguyen"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448717","@type":"Researcher","foaf:name":[{"@value":"Roel Goldschmeding"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448715","@type":"Researcher","foaf:name":[{"@value":"Bassam Alchi"}],"jpcoar:affiliationName":[{"@value":"Renal Department, Royal Berkshire Hospital, Reading, Berkshire, United Kingdom;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448713","@type":"Researcher","foaf:name":[{"@value":"Meryl Griffiths"}],"jpcoar:affiliationName":[{"@value":"Department of Histopathology, Addenbrooke’s Hospital, Cambridge, United Kingdom; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448714","@type":"Researcher","foaf:name":[{"@value":"Janak R. de Zoysa"}],"jpcoar:affiliationName":[{"@value":"Department of Nephrology, North Shore Hospital, Auckland, New Zealand"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448708","@type":"Researcher","foaf:name":[{"@value":"Beula Vincent"}],"jpcoar:affiliationName":[{"@value":"Department of Nephrology, North Shore Hospital, Auckland, New Zealand"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448709","@type":"Researcher","foaf:name":[{"@value":"Jan A. Bruijn"}],"jpcoar:affiliationName":[{"@value":"Pathology and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380294646711448710","@type":"Researcher","foaf:name":[{"@value":"Ingeborg M. Bajema"}],"jpcoar:affiliationName":[{"@value":"Pathology and"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15559041"},{"@type":"EISSN","@value":"1555905X"}],"prism:publicationName":[{"@value":"Clinical Journal of the American Society of Nephrology"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2017-11-21","prism:volume":"13","prism:number":"1","prism:startingPage":"63","prism:endingPage":"72"},"reviewed":"false","url":[{"@id":"https://journals.lww.com/01277230-201801000-00013"}],"createdAt":"2017-11-22","modifiedAt":"2023-08-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360302866851514496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Serum sulfatide level is associated with severe systemic vasculitis with kidney involvement"}]},{"@id":"https://cir.nii.ac.jp/crid/1390859616450180992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Rituximab for the Treatment of Anti-glomerular Basement Membrane Disease with Isolated Diffuse Alveolar Hemorrhage"}]},{"@id":"https://cir.nii.ac.jp/crid/2050307417129991168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Epidemiology and temporal changes in the prognosis of rapidly progressive glomerulonephritis in Japan : a nationwide 1989-2015 survey"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.2215/cjn.04290417"},{"@type":"CROSSREF","@value":"10.1007/s10157-021-02148-y_references_DOI_VYoxPq3IxWrwki2wqURaCugPOse"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.0166-22_references_DOI_VYoxPq3IxWrwki2wqURaCugPOse"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2023.1271741_references_DOI_VYoxPq3IxWrwki2wqURaCugPOse"}]}