{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360298337115995136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3389/fonc.2022.744886"}},{"identifier":{"@type":"URI","@value":"https://www.frontiersin.org/articles/10.3389/fonc.2022.744886/full"}},{"identifier":{"@type":"PMID","@value":"35350574"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"The Oncogenic Effects, Pathways, and Target Molecules of JC Polyoma Virus T Antigen in Cancer Cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>JC polyoma virus (JCPyV) is a ubiquitous polyoma virus that infects the individual to cause progressive multifocal leukoencephalopathy and malignancies. Here, we found that T-antigen knockdown suppressed proliferation, glycolysis, mitochondrial respiration, migration, and invasion, and induced apoptosis and G<jats:sub>2</jats:sub> arrest. The reverse was true for T-antigen overexpression, with overexpression of Akt, survivin, retinoblastoma protein, β-catenin, β-transducin repeat-containing protein (TRCP), and inhibitor of growth (ING)1, and the underexpression of mammalian target of rapamycin (mTOR), phosphorylated (p)-mTOR, p-p38, Cyclin D1, p21, vascular endothelial growth factor (VEGF), ING2, and ING4 in hepatocellular and pancreatic cancer cells and tissues. In lens tumor cells, T antigen transcriptionally targeted viral carcinogenesis, microRNAs in cancer, focal adhesion, p53, VEGF, phosphoinositide 3 kinase-Akt, and Forkhead box O signaling pathways, fructose and mannose metabolism, ribosome biosynthesis, and choline and pyrimidine metabolism. At a metabolomics level, it targeted protein digestion and absorption, aminoacryl-tRNA biosynthesis, biosynthesis of amino acids, and the AMPK signal pathway. At a proteomic level, it targeted ribosome biogenesis in eukaryotes, citrate cycle, carbon metabolism, protein digestion and absorption, aminoacryl-tRNA biosynthesis, extracellular-matrix-receptor interaction, and biosynthesis of amino acids. In lens tumor cells, T antigen might interact with various keratins, ribosomal proteins, apolipoproteins, G proteins, ubiquitin-related proteins, RPL19, β-catenin, β-TRCP, p53, and CCAAT-enhancer-binding proteins in lens tumor cells. T antigen induced a more aggressive phenotype in mouse and human cancer cells due to oncogene activation, inactivation of tumor suppressors, and disruption of metabolism, cell adhesion, and long noncoding RNA-microRNA-target axes.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380298337115995271","@type":"Researcher","foaf:name":[{"@value":"Hua-Chuan Zheng"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298337115995289","@type":"Researcher","foaf:name":[{"@value":"Hang Xue"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298337115995284","@type":"Researcher","foaf:name":[{"@value":"Yu-Zi Jin"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298337115995274","@type":"Researcher","foaf:name":[{"@value":"Hua-Mao Jiang"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751167492864","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90572115"},{"@type":"NRID","@value":"1000090572115"},{"@type":"NRID","@value":"9000351079497"}],"foaf:name":[{"@value":"Zheng-Guo Cui"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"2234943X"}],"prism:publicationName":[{"@value":"Frontiers in Oncology"}],"dc:publisher":[{"@value":"Frontiers Media SA"}],"prism:publicationDate":"2022-03-08","prism:volume":"12"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.frontiersin.org/articles/10.3389/fonc.2022.744886/full"}],"createdAt":"2022-03-08","modifiedAt":"2022-03-08","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=signal%20pathway","dc:title":"signal pathway"},{"@id":"https://cir.nii.ac.jp/all?q=Oncology","dc:title":"Oncology"},{"@id":"https://cir.nii.ac.jp/all?q=JC%20virus%20T%20antigen","dc:title":"JC virus T antigen"},{"@id":"https://cir.nii.ac.jp/all?q=oncogenesis","dc:title":"oncogenesis"},{"@id":"https://cir.nii.ac.jp/all?q=WNT/beta-catenin%20pathway","dc:title":"WNT/beta-catenin pathway"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms.%20Tumors.%20Oncology.%20Including%20cancer%20and%20carcinogens","dc:title":"Neoplasms. Tumors. Oncology. Including cancer and carcinogens"},{"@id":"https://cir.nii.ac.jp/all?q=PI3k-Akt%20signal%20pathway","dc:title":"PI3k-Akt signal pathway"},{"@id":"https://cir.nii.ac.jp/all?q=RC254-282","dc:title":"RC254-282"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040848250655895680","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20K10449"},{"@type":"JGN","@value":"JP20K10449"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K10449/"}],"notation":[{"@language":"ja","@value":"慢性ヒ素中毒による肺がん発生に特異的なmiRNAを標的とした新規予防法の開発"},{"@language":"en","@value":"A Novel Approach to Target Specific miRNAs for Prevention of Arsenic-induced Lung Cancer Development"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360013171111061632","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"JC Virus T-Antigen Regulates Glucose Metabolic Pathways in Brain Tumor Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016867207860096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Stability and Function of JC Virus Large T Antigen and T′ Proteins Are Altered by Mutation of Their Phosphorylated Threonine 125 Residues"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016867506389376","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"JCPyV miR-J1-5p in Urine of Natalizumab-Treated Multiple Sclerosis Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016869101557760","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Faecal ribosomal protein L19 is a genetic prognostic factor for survival in colorectal cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360016869797442304","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of Polyomavirus Transcription by Viral and Cellular 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expression after infection in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298341497667584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic and Functional Dissection of the Role of Individual 5-HT2 Receptors as Entry Receptors for JC Polyomavirus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298342473504768","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The role of mTOR in age-related diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298343146363136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"JC Polyomavirus Infection Potentiated by Biologics"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298345255134720","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Interaction between JCV large T-antigen and 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Ribosomal Protein Gene RPL19 Abrogates the Aggressive Phenotype of Human Prostate Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1363951794425936256","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"IFN-Gamma Inhibits JC Virus Replication in Glial Cells by Suppressing T-Antigen Expression"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3389/fonc.2022.744886"},{"@type":"KAKEN","@value":"PRODUCT-24007301"},{"@type":"OPENAIRE","@value":"doi_dedup___::ea8033f70d9c74c175f2659a93999057"}]}