{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360298339727707008.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/jjco/hyac070"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jjco/article-pdf/52/8/911/46214327/hyac070.pdf"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2023195134"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Risk of radiculopathy caused by second course of spine stereotactic body radiotherapy"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n               <jats:sec>\n                  <jats:title>Objective</jats:title>\n                  <jats:p>Stereotactic body radiotherapy is used to treat spinal metastases; however, 10% of patients experience local failure. We aimed to clarify the outcomes of the second course of stereotactic body radiotherapy for spinal metastases with a uniform fractionation schedule at our institution.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Methods</jats:title>\n                  <jats:p>Data of patients treated with a second salvage stereotactic body radiotherapy course at the same spinal level or adjacent level from July 2018 to December 2020 were retrospectively reviewed. The initial prescribed dose was 24 Gy in two fractions, and the second dose 30 or 35 Gy in five fractions. The spinal cord dose constraint at the second course was 15.5 Gy at the maximum point dose. The endpoints were local failure and adverse effects. Local failure was defined as tumor progression using imaging.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Results</jats:title>\n                  <jats:p>We assessed 19 lesions in 17 patients, with radioresistant lesions in 14 (74%) cases, the second stereotactic body radiotherapy to the same/adjacent spinal level in 13/6 cases, the median interval between stereotactic body radiotherapy of 23 (range, 6–52) months, and lesions compressing the cord in 5 (26%) cases. The median follow-up period was 19 months. The 12- and 18-month local failure rates were 0% and 8%, respectively. Radiation-induced myelopathy, radiculopathy and vertebral compression fractures were observed in 0 (0%), 4 (21%) and 2 (11%) lesions, respectively. Three patients with radiculopathy experienced almost complete upper or lower limb paralysis.</jats:p>\n               </jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions</jats:title>\n                  <jats:p>The second course of salvage stereotactic body radiotherapy for spinal metastases achieved good local control with a reduced risk of myelopathy. However, a high occurrence rate of radiation-induced radiculopathy has been confirmed.</jats:p>\n               </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380298339727707022","@type":"Researcher","foaf:name":[{"@value":"Kei Ito"}],"jpcoar:affiliationName":[{"@value":"Division of Radiation Oncology , Department of Radiology, , Bunkyo-ku, Tokyo, Japan"},{"@value":"Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Department of Radiology, , Bunkyo-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801206671744","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20799530"},{"@type":"NRID","@value":"1000020799530"},{"@type":"NRID","@value":"9000411979893"},{"@type":"NRID","@value":"9000414253564"},{"@type":"NRID","@value":"9000340462065"},{"@type":"NRID","@value":"9000412112883"},{"@type":"NRID","@value":"9000413259863"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/20799530"}],"foaf:name":[{"@value":"Yujiro Nakajima"}],"jpcoar:affiliationName":[{"@value":"Division of Radiation Oncology , Department of Radiology, , Bunkyo-ku, Tokyo, Japan"},{"@value":"Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Department of Radiology, , Bunkyo-ku, Tokyo, Japan"},{"@value":"Department of Radiological Sciences, Komazawa University , Setagaya-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298339727707012","@type":"Researcher","foaf:name":[{"@value":"Hiroaki Ogawa"}],"jpcoar:affiliationName":[{"@value":"Division of Radiation Oncology , Department of Radiology, , Bunkyo-ku, Tokyo, Japan"},{"@value":"Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Department of Radiology, , Bunkyo-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298339727707017","@type":"Researcher","foaf:name":[{"@value":"Kentaro Taguchi"}],"jpcoar:affiliationName":[{"@value":"Division of Radiation Oncology , Department of Radiology, , Bunkyo-ku, Tokyo, Japan"},{"@value":"Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Department of Radiology, , Bunkyo-ku, Tokyo, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298339727707014","@type":"Researcher","foaf:name":[{"@value":"Shurei Sugita"}],"jpcoar:affiliationName":[{"@value":"Department of Orthopedic surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Bunkyo-ku, Tokyo, 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