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This study compared and assessed the metabolic profile of head and neck squamous cell carcinoma (HNSCC) and normal tissues, which were collected from patients without cancer.</jats:p></jats:sec><jats:sec><jats:title>Subjects and Methods</jats:title><jats:p>Overall, 23 patients with HNSCC and 6 patients without cancer were included in the analysis. Metabolomic profiles were analyzed using capillary electrophoresis‐mass spectrometry. Gene expression was evaluated using real‐time reverse transcription‐polymerase chain reaction.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Glycolysis, the pentose phosphate pathway, tricarboxylic acid cycle, and glutamine metabolism were upregulated in HNSCC tissues based on gene expression analysis. HNSCC could then have enhanced energy production and structural component. The levels of lactate, succinate, glutathione, 2‐hydroxyglutarate, and S‐adenosylmethionine, considered as oncometabolites, increased and these had accumulated in HNSCC tissues.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The level of metabolites and the expression of enzymes differ between HNSCC and normal tissues. Reprogramming metabolism in HNSCC provides an energy source as well as structural components, creating a system that offers rapid proliferation, progression, and is less likely to be eliminated.</jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326225346304","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80707860"},{"@type":"NRID","@value":"1000080707860"},{"@type":"NRID","@value":"9000001979762"},{"@type":"NRID","@value":"9000412044176"},{"@type":"NRID","@value":"9000406357262"},{"@type":"NRID","@value":"9000257920566"},{"@type":"NRID","@value":"9000242142516"},{"@type":"NRID","@value":"9000413253252"},{"@type":"NRID","@value":"9000021550532"},{"@type":"NRID","@value":"9000413247608"},{"@type":"NRID","@value":"9000412032583"},{"@type":"NRID","@value":"9000399004351"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000014624"}],"foaf:name":[{"@value":"Toshimitsu 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