{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360298757408099712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.15252/embj.2021109457"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2021109457"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.15252/embj.2021109457"}},{"identifier":{"@type":"URI","@value":"https://www.embopress.org/doi/pdf/10.15252/embj.2021109457"}},{"identifier":{"@type":"PMID","@value":"35603814"}},{"identifier":{"@type":"HANDLE","@value":"10230/53522"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Controlled X‐chromosome dynamics defines meiotic potential of female mouse\n                    <i>in vitro</i>\n                    germ cells"}],"description":[{"notation":[{"@value":"The mammalian germline is characterized by extensive epigenetic reprogramming during its development into functional eggs and sperm. Specifically, the epigenome requires resetting before parental marks can be established and transmitted to the next generation. In the female germline, X-chromosome inactivation and reactivation are among the most prominent epigenetic reprogramming events, yet very little is known about their kinetics and biological function. Here, we investigate X-inactivation and reactivation dynamics using a tailor-made in vitro system of primordial germ cell-like cell (PGCLC) differentiation from mouse embryonic stem cells. We find that X-inactivation in PGCLCs in vitro and in germ cell-competent epiblast cells in vivo is moderate compared to somatic cells, and frequently characterized by escaping genes. X-inactivation is followed by step-wise X-reactivation, which is mostly completed during meiotic prophase I. Furthermore, we find that PGCLCs which fail to undergo X-inactivation or reactivate too rapidly display impaired meiotic potential. Thus, our data reveal fine-tuned X-chromosome remodelling as a critical feature of female germ cell development towards meiosis and oogenesis."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380298757408099713","@type":"Researcher","foaf:name":[{"@value":"Jacqueline Severino"}],"jpcoar:affiliationName":[{"@value":"Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology  Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298757408099840","@type":"Researcher","foaf:name":[{"@value":"Moritz Bauer"}],"jpcoar:affiliationName":[{"@value":"Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology  Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298757408099718","@type":"Researcher","foaf:name":[{"@value":"Tom Mattimoe"}],"jpcoar:affiliationName":[{"@value":"Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology  Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298757408099714","@type":"Researcher","foaf:name":[{"@value":"Niccolò Arecco"}],"jpcoar:affiliationName":[{"@value":"Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology  Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298757408099842","@type":"Researcher","foaf:name":[{"@value":"Luca Cozzuto"}],"jpcoar:affiliationName":[{"@value":"Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology  Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298757408099712","@type":"Researcher","foaf:name":[{"@value":"Patricia Lorden"}],"jpcoar:affiliationName":[{"@value":"CNAG‐CRG, Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology (BIST)  Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298757408099719","@type":"Researcher","foaf:name":[{"@value":"Norio Hamada"}],"jpcoar:affiliationName":[{"@value":"Department of Obstetrics and Gynecology Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298757408099841","@type":"Researcher","foaf:name":[{"@value":"Yoshiaki Nosaka"}],"jpcoar:affiliationName":[{"@value":"Institute for the Advanced Study of Human Biology (ASHBi) Kyoto University  Kyoto Japan"},{"@value":"Department of Anatomy and Cell Biology Graduate School of Medicine Kyoto University  Kyoto Japan"},{"@value":"Center for iPS Cell Research and Application (CiRA) Kyoto University  Kyoto Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298757408099715","@type":"Researcher","foaf:name":[{"@value":"So I Nagaoka"}],"jpcoar:affiliationName":[{"@value":"Institute for the Advanced Study of Human Biology (ASHBi) Kyoto University  Kyoto Japan"},{"@value":"Department of Anatomy and Cell Biology Graduate School of Medicine Kyoto University  Kyoto Japan"},{"@value":"Center for iPS Cell Research and Application (CiRA) Kyoto University  Kyoto Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298757408099722","@type":"Researcher","foaf:name":[{"@value":"Pauline Audergon"}],"jpcoar:affiliationName":[{"@value":"Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology  Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298757408099721","@type":"Researcher","foaf:name":[{"@value":"Antonio Tarruell"}],"jpcoar:affiliationName":[{"@value":"Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology  Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298757408099716","@type":"Researcher","foaf:name":[{"@value":"Holger Heyn"}],"jpcoar:affiliationName":[{"@value":"CNAG‐CRG, Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology (BIST)  Barcelona Spain"},{"@value":"Universitat Pompeu Fabra (UPF)  Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276160440832","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"20287486"},{"@type":"NRID","@value":"1000020287486"},{"@type":"ORCID","@value":"0000-0002-2479-2941"}],"foaf:name":[{"@value":"Katsuhiko Hayashi"}],"jpcoar:affiliationName":[{"@value":"Department of Stem Cell Biology and Medicine Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298757408099717","@type":"Researcher","foaf:name":[{"@value":"Mitinori Saitou"}],"jpcoar:affiliationName":[{"@value":"Institute for the Advanced Study of Human Biology (ASHBi) Kyoto University  Kyoto Japan"},{"@value":"Department of Anatomy and Cell Biology Graduate School of Medicine Kyoto University  Kyoto Japan"},{"@value":"Center for iPS Cell Research and Application (CiRA) Kyoto University  Kyoto Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298757408099723","@type":"Researcher","foaf:name":[{"@value":"Bernhard Payer"}],"jpcoar:affiliationName":[{"@value":"Centre for Genomic Regulation (CRG) The Barcelona Institute of Science and Technology  Barcelona Spain"},{"@value":"Universitat Pompeu Fabra (UPF)  Barcelona Spain"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1891429165878929536","@type":"Researcher","foaf:name":[{"@value":"Hubrecht Institute with UMC"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02614189"},{"@type":"EISSN","@value":"14602075"}],"prism:publicationName":[{"@value":"The EMBO Journal"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2022-05-23","prism:volume":"41","prism:number":"12"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.2021109457"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.15252/embj.2021109457"},{"@id":"https://www.embopress.org/doi/pdf/10.15252/embj.2021109457"}],"createdAt":"2022-05-23","modifiedAt":"2025-12-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Mammals","dc:title":"Mammals"},{"@id":"https://cir.nii.ac.jp/all?q=General%20Immunology%20and%20Microbiology","dc:title":"General Immunology and Microbiology"},{"@id":"https://cir.nii.ac.jp/all?q=General%20Neuroscience","dc:title":"General Neuroscience"},{"@id":"https://cir.nii.ac.jp/all?q=General%20Biochemistry,Genetics%20and%20Molecular%20Biology","dc:title":"General Biochemistry,Genetics and Molecular Biology"},{"@id":"https://cir.nii.ac.jp/all?q=epigenetic%20reprogramming","dc:title":"epigenetic reprogramming"},{"@id":"https://cir.nii.ac.jp/all?q=X-chromosome%20inactivation","dc:title":"X-chromosome inactivation"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Differentiation","dc:title":"Cell Differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=Articles","dc:title":"Articles"},{"@id":"https://cir.nii.ac.jp/all?q=Epigen%C3%A8tica","dc:title":"Epigenètica"},{"@id":"https://cir.nii.ac.jp/all?q=Chromosomes","dc:title":"Chromosomes"},{"@id":"https://cir.nii.ac.jp/all?q=Cromosoma%20X","dc:title":"Cromosoma X"},{"@id":"https://cir.nii.ac.jp/all?q=C%C3%A8l%C2%B7lules%20germinals","dc:title":"Cèl·lules germinals"},{"@id":"https://cir.nii.ac.jp/all?q=Meiosis","dc:title":"Meiosis"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Germ%20Cells","dc:title":"Germ Cells"},{"@id":"https://cir.nii.ac.jp/all?q=X%20Chromosome%20Inactivation","dc:title":"X Chromosome Inactivation"},{"@id":"https://cir.nii.ac.jp/all?q=in%20vitro%20model","dc:title":"in vitro model"},{"@id":"https://cir.nii.ac.jp/all?q=meiosis","dc:title":"meiosis"},{"@id":"https://cir.nii.ac.jp/all?q=primordial%20germ%20cells","dc:title":"primordial germ cells"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Biology","dc:title":"Molecular Biology"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000781994978432","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H05544"},{"@type":"JGN","@value":"JP18H05544"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-18H05544/"}],"notation":[{"@language":"ja","@value":"配偶子インテグリティの構築"},{"@language":"en","@value":"Ensuring integrity of gametogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1040003825727922432","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"20K15801"},{"@type":"JGN","@value":"JP20K15801"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K15801/"}],"notation":[{"@language":"ja","@value":"転写因子ZGLP1によるマウス始原生殖細胞の雌性運命決定機構の解明"},{"@language":"en","@value":"Mechanism of female germ cell fate determination by a transcription factor ZGLP1"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282256971688448","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"18H05545"},{"@type":"JGN","@value":"JP18H05545"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-18H05545/"}],"notation":[{"@language":"ja","@value":"多能性幹細胞による配偶子産生システムのin vitro再構築"},{"@language":"en","@value":"Reconstitution of gamete integrity using pluripotent stem cells"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050008212372799360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass"}]},{"@id":"https://cir.nii.ac.jp/crid/1050292936859776512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1050848249735156608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"ZGLP1 is a determinant for the oogenic fate in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002215852223104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A Signaling Principle for the Specification of the Germ Cell Lineage in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216079863296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tsix RNA and the Germline Factor, PRDM14, Link X Reactivation and Stem Cell Reprogramming"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216168590336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233445743360","@type":"Article","resourceType":"学術雑誌論文(journal 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      Regulation and Pluripotency"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013173199716224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"X-Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017285539048448","@type":"Article","resourceType":"preprint","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"X upregulation is not global and extent of upregulation differs between ancestral and acquired X-linked genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017288453758336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017288454708480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"New Insights into X-Chromosome Reactivation during Reprogramming to Pluripotency"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017289637395584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690829006976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690865159040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Global Landscape and Regulatory Principles of DNA Methylation Reprogramming for Germ Cell Specification by Mouse Pluripotent Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285705284654080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of Primordial Germ Cell-Like Cells From Mouse Embryonic Stem Cells by ERK Signal Inhibition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706909204352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of fetal primary oocytes and the meiotic prophase from mouse pluripotent stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292617907951488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"limma powers differential expression analyses for RNA-sequencing and microarray studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621280786176","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292621316315136","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294646213978112","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"WASP: allele-specific software for robust molecular quantitative trait locus discovery"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298755607953536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298762039421824","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Identification of X-chromosomal genes that drive sex differences in embryonic stem cells through a hierarchical CRISPR screening approach"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298762763722880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Genetic Intersection of Tsix and Hedgehog Signaling during the Initiation of X-Chromosome Inactivation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166752329216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Induction of mouse germ-cell fate by transcription factors in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168392040064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Offspring from Oocytes Derived from in Vitro Primordial Germ Cell–like Cells in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574092892962688","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fiji: an open-source platform for biological-image analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574096379482880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Embryonic germ cells from mice and rats exhibit properties consistent with a generic pluripotent ground state"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580234547917440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580234570438784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Single‐cell RNA sequencing reveals the landscape of early female germ cell development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580234908944128","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Tissue of Origin, but Not XCI State, Influences Germ Cell Differentiation from Human Pluripotent Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580236933512320","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Elastic dosage compensation by X-chromosome upregulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360585254925787392","@type":"Article","resourceType":"preprint","relationType":["hasPreprint"],"jpcoar:relatedTitle":[{"@value":"A temporally controlled sequence of X-chromosome inactivation and reactivation defines female mouse\n                  <i>in vitro</i>\n                  germ cells with meiotic potential"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640782561920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"X Chromosome Reactivation Dynamics Reveal Stages of Reprogramming to Pluripotency"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641743065728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Reconstitution of mouse oogenesis in a dish from pluripotent stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846644618955776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"<i>In vitro</i>\n                    expansion of mouse primordial germ cell‐like cells recapitulates an epigenetic blank slate"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848662855929728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Bone morphogenetic protein and retinoic acid synergistically specify female germ‐cell fate in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855567860394624","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"STAR: ultrafast universal RNA-seq aligner"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855567860583040","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569923689472","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"LIF signaling in stem cells and development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570329475328","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855570584918016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Clonal Analysis of the Origin 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