{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360298760894366464.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/ddr.21509"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fddr.21509"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ddr.21509"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ddr.21509"}},{"identifier":{"@type":"URI","@value":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/ddr.21509"}}],"dc:title":[{"@value":"Curcumin reduces inflammation in knee osteoarthritis rats through blocking TLR4 /MyD88/NF‐κB signal pathway"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p><jats:table-wrap position=\"anchor\">\n\n<jats:table frame=\"hsides\">\n<jats:col/>\n<jats:tbody>\n<jats:tr>\n<jats:td>Preclinical Research & Development</jats:td>\n</jats:tr>\n</jats:tbody>\n</jats:table>\n\n</jats:table-wrap></jats:p><jats:p>Curcumin has been shown to possess a series of beneficial effects, such as antiinflammatory, antioxidant, analgesic, and promoting healing. However, the effect and relative mechanism of curcumin on knee osteoarthritis (OA) have not been elucidated. The aim of this study is to explore the protective effect of curcumin on monosodium iodoacetate (MIA)‐induced OA. Forty‐eight rats were randomized into four experimental groups: control group, OA group, OA + PBS group, and OA + curcumin group, respectively. A single intraarticular injection of MIA was applied to establish the rat model of knee OA. Hematoxylin–eosin staining was used to evaluate histological changes of knee joint. The paw withdrawal threshold was collected and the expression of synovial fluid cytokine levels was measured by ELISA. The protein expression of TRL‐4, MyD88, p‐IκBα, NF‐κB, TNF‐α, IL‐1β, and IL6 was measured by western blot. Treating with curcumin can significantly reduce joint diameter and Mankin's score, and increase the paw withdrawal threshold. The expression of synovial fluid inflammatory biomarkers, IL‐6, IL‐1β, and TNF‐α in the OA + curcumin group were lower than that in OA and OA + PBS group. The protein expression of the TLR4 receptor was increased in the OA, OA + PBS, and OA + curcumin group compared to the control group. However, curcumin treatment can significantly decrease the expression of MyD88, p‐IκBα, NF‐κB, TNF‐α, IL‐1β, and IL6 in OA + curcumin group. These findings may indicate that curcumin could block TLR4/NF‐κB signal pathway, and reduce inflammation level to prevent knee wound in OA rats. Curcumin may be a feasible kind of medicament in the treatment of knee OA.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380298760894366464","@type":"Researcher","foaf:name":[{"@value":"Yun Zhang"}],"jpcoar:affiliationName":[{"@value":"Department of Orthopedics of Traditional Chinese Medicine Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital  Chengdu China"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298760894366465","@type":"Researcher","foaf:name":[{"@value":"Yu Zeng"}],"jpcoar:affiliationName":[{"@value":"Department of Hyperbaric Oxygen Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital  Chengdu China"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02724391"},{"@type":"EISSN","@value":"10982299"}],"prism:publicationName":[{"@value":"Drug Development Research"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2019-01-21","prism:volume":"80","prism:number":"3","prism:startingPage":"353","prism:endingPage":"359"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fddr.21509"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ddr.21509"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ddr.21509"},{"@id":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/ddr.21509"}],"createdAt":"2019-01-21","modifiedAt":"2025-10-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360017282431984768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intra-Articular Injections of Curcumin Monoglucuronide TBP1901 Suppresses Articular Cartilage Damage and Regulates Subchondral Bone Alteration in an Osteoarthritis Rat Model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306906080872704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pathophysiology of the Effects of Oxidative Stress on the Skeletal System"}]},{"@id":"https://cir.nii.ac.jp/crid/1390020984102947200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Functional Ingredients Associated with the Prevention and Suppression of Locomotive Syndrome: A Review"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/ddr.21509"},{"@type":"CROSSREF","@value":"10.1177/19476035211043202_references_DOI_7BliybAO55GURsCeklHSanfXak6"},{"@type":"CROSSREF","@value":"10.1248/bpb.b24-00443_references_DOI_7BliybAO55GURsCeklHSanfXak6"},{"@type":"CROSSREF","@value":"10.1002/jor.26075_references_DOI_7BliybAO55GURsCeklHSanfXak6"}]}