Histatin-Derived Monomeric and Dimeric Synthetic Peptides Show Strong Bactericidal Activity towards Multidrug-Resistant <i>Staphylococcus aureus</i> In Vivo

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  • Mick M. Welling
    Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands
  • Carlo P. J. M. Brouwer
    R&D, AM-Pharma, Bunnik, the Netherlands
  • Wim van ′t Hof
    Academic Centre for Dentistry Amsterdam (ACTA), Department of Oral Biochemistry, Amsterdam, the Netherlands
  • Enno C. I. Veerman
    Academic Centre for Dentistry Amsterdam (ACTA), Department of Oral Biochemistry, Amsterdam, the Netherlands
  • Arie V. Nieuw Amerongen
    Academic Centre for Dentistry Amsterdam (ACTA), Department of Oral Biochemistry, Amsterdam, the Netherlands

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<jats:title>ABSTRACT</jats:title> <jats:p> Homodimerization of histatin-derived peptides generally led to improved bactericidal activity against <jats:italic>Staphylococcus aureus</jats:italic> in vitro. In vivo, monomers and dimers were equally active in killing bacteria in mice with a soft tissue infection. Altogether, these peptides are promising compounds for the development of novel therapeutics against infections with drug-resistant bacteria. </jats:p>

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