Histatin-Derived Monomeric and Dimeric Synthetic Peptides Show Strong Bactericidal Activity towards Multidrug-Resistant <i>Staphylococcus aureus</i> In Vivo
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- Mick M. Welling
- Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands
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- Carlo P. J. M. Brouwer
- R&D, AM-Pharma, Bunnik, the Netherlands
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- Wim van ′t Hof
- Academic Centre for Dentistry Amsterdam (ACTA), Department of Oral Biochemistry, Amsterdam, the Netherlands
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- Enno C. I. Veerman
- Academic Centre for Dentistry Amsterdam (ACTA), Department of Oral Biochemistry, Amsterdam, the Netherlands
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- Arie V. Nieuw Amerongen
- Academic Centre for Dentistry Amsterdam (ACTA), Department of Oral Biochemistry, Amsterdam, the Netherlands
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説明
<jats:title>ABSTRACT</jats:title> <jats:p> Homodimerization of histatin-derived peptides generally led to improved bactericidal activity against <jats:italic>Staphylococcus aureus</jats:italic> in vitro. In vivo, monomers and dimers were equally active in killing bacteria in mice with a soft tissue infection. Altogether, these peptides are promising compounds for the development of novel therapeutics against infections with drug-resistant bacteria. </jats:p>
収録刊行物
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- Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy 51 (9), 3416-3419, 2007-09
American Society for Microbiology