- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
A mouse T cell product that preferentially enhances IgA production. II. Physicochemical characterization.
-
- M W Bond
- DNAX Research Institute of Molecular and Cellular Biology , Palo Alto, CA 94304
-
- B Shrader
- DNAX Research Institute of Molecular and Cellular Biology , Palo Alto, CA 94304
-
- T R Mosmann
- DNAX Research Institute of Molecular and Cellular Biology , Palo Alto, CA 94304
-
- R L Coffman
- DNAX Research Institute of Molecular and Cellular Biology , Palo Alto, CA 94304
Search this article
Description
<jats:title>Abstract</jats:title> <jats:p>Certain subsets of helper T cells, following stimulation with concanavalin A, secrete factors that specifically enhance the production of IgG1, IgE, and IgA by lipopolysaccharide-stimulated B cells. In the previous report, we describe a factor from the helper T cell line MB2-1 which enhances IgA production. IgA-enhancing factor has been purified from serum-free supernatants of this cell line. The purified lymphokine is a family of microheterogeneous polypeptides presumably modified post-translationally. IgA-enhancing factor has a native m.w. of 45,000 to 60,000 with subunits of between 24,000 and 28,000 under reducing conditions. Upon Edman degradation, a single amino-terminal sequence is detected which is identical to that of the lymphokine interleukin 5. IgA-enhancing factor activity is thus mediated by the same polypeptide that has been characterized as type II B cell growth factor, T cell-replacing factor, and eosinophil-differentiation factor.</jats:p>
Journal
-
- The Journal of Immunology
-
The Journal of Immunology 139 (11), 3691-3696, 1987-12-01
Oxford University Press (OUP)
- Tweet
Details 詳細情報について
-
- CRID
- 1360299152186947712
-
- ISSN
- 15506606
- 00221767
- http://id.crossref.org/issn/00221767
-
- Data Source
-
- Crossref