{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360302865730078336.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.addr.2023.114895"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0169409X23002107?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0169409X23002107?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"37211278"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Stealth and pseudo-stealth nanocarriers"}],"description":[{"notation":[{"@value":"The stealth effect plays a central role on capacitating nanomaterials for drug delivery applications through improving the pharmacokinetics such as blood circulation, biodistribution, and tissue targeting. Here based on a practical analysis of stealth efficiency and a theoretical discussion of relevant factors, we provide an integrated material and biological perspective in terms of engineering stealth nanomaterials. The analysis surprisingly shows that more than 85% of the reported stealth nanomaterials encounter a rapid drop of blood concentration to half of the administered dose within 1 h post administration although a relatively long β-phase is observed. A term, pseudo-stealth effect, is used to delineate this common pharmacokinetics behavior of nanomaterials, that is, dose-dependent nonlinear pharmacokinetics because of saturating or depressing bio-clearance of reticuloendothelial system (RES). We further propose structural holism can be a watershed to improve the stealth effect; that is, the whole surface structure and geometry play important roles, rather than solely relying on a single factor such as maximizing repulsion force through polymer-based steric stabilization (e.g., PEGylation) or inhibiting immune attack through a bio-inspired component. Consequently, engineering delicate structural hierarchies to minimize attractive binding sites, that is, minimal charges/dipole and hydrophobic domain, becomes crucial. In parallel, the pragmatic implementation of the pseudo-stealth effect and dynamic modulation of the stealth effect are discussed for future development."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380302865730077990","@type":"Researcher","foaf:name":[{"@value":"Wendong Ke"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658700380800","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70794353"},{"@type":"NRID","@value":"1000070794353"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/DirisalaAnjaneyulu12"}],"foaf:name":[{"@value":"Anjaneyulu Dirisala"}]},{"@id":"https://cir.nii.ac.jp/crid/1380302865730077971","@type":"Researcher","foaf:name":[{"@value":"Kazuko Toh"}]},{"@id":"https://cir.nii.ac.jp/crid/1380302865730078210","@type":"Researcher","foaf:name":[{"@value":"Panyue Wen"}]},{"@id":"https://cir.nii.ac.jp/crid/1380302865730078110","@type":"Researcher","foaf:name":[{"@value":"Masaru Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801202323840","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80869892"},{"@type":"NRID","@value":"1000080869892"}],"foaf:name":[{"@value":"Junjie Li"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0169409X"}],"prism:publicationName":[{"@value":"Advanced Drug Delivery Reviews"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2023-07","prism:volume":"198","prism:startingPage":"114895"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://www.elsevier.com/open-access/userlicense/1.0/","https://doi.org/10.15223/policy-017","https://doi.org/10.15223/policy-037","https://doi.org/10.15223/policy-012","https://doi.org/10.15223/policy-029","https://doi.org/10.15223/policy-004"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0169409X23002107?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0169409X23002107?httpAccept=text/plain"}],"createdAt":"2023-05-19","modifiedAt":"2025-09-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Kinetics","dc:title":"Kinetics"},{"@id":"https://cir.nii.ac.jp/all?q=Drug%20Delivery%20Systems","dc:title":"Drug Delivery Systems"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Tissue%20Distribution","dc:title":"Tissue Distribution"},{"@id":"https://cir.nii.ac.jp/all?q=Polyethylene%20Glycols","dc:title":"Polyethylene Glycols"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040006432262936960","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21K18062"},{"@type":"JGN","@value":"JP21K18062"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K18062/"}],"notation":[{"@language":"ja","@value":"Ligand-free hepatocyte-targeting of nanomedicines by selective stealth coating of liver reticuloendothelial system scavenger cells"},{"@language":"en","@value":"Ligand-free hepatocyte-targeting of nanomedicines by selective stealth coating of liver reticuloendothelial system scavenger 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