{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360302866849552000.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1097/pas.0000000000002029"}},{"identifier":{"@type":"URI","@value":"https://journals.lww.com/10.1097/PAS.0000000000002029"}},{"identifier":{"@type":"PMID","@value":"36876749"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"CYP1A1 Is a Useful Diagnostic Marker for Angiofibroma of Soft Tissue"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Angiofibroma of soft tissue (AFST) is a recently described benign fibroblastic neoplasm composed of uniform bland spindle cell proliferation in fibrous and fibromyxoid stroma with prominent thin-walled small branching vessels. A major recurrent genetic abnormality in AFST is t(5;8)(p15;q13), which results in the rearrangement of <jats:italic toggle=\"yes\">AHRR</jats:italic> and <jats:italic toggle=\"yes\">NCOA2</jats:italic>. Owing to a lack of discriminatory IHC markers and potential overlap with other mesenchymal neoplasms, it may be difficult to confirm the diagnosis of AFST in some cases. Triggered by a recent gene expression profile study of AFST, which showed the significant upregulation of AhR/AHRR/ARNT downstream genes (including <jats:italic toggle=\"yes\">CYP1A1</jats:italic>), we used a mouse monoclonal antibody to explore the diagnostic significance of CYP1A1 expression in histologically confirmed AFST cases along with 224 control cases, consisting of 221 neoplastic mimickers and 3 non-neoplastic lesions. We found moderate to strong cytoplasmic expression of CYP1A1 in 13 of 16 AFST cases (sensitivity, 81.3%). In contrast, the vast majority of other examined histologic mimickers exhibited no expression of CYP1A1 (specificity, 97.3%), except for 3 myxofibrosarcomas (3/31), 2 solitary fibrous tumors (2/22), and 2 neurofibroma (1/27). Our results indicate that CYP1A1 immunohistochemistry may aid in the diagnosis of AFST by distinguishing among various kinds of tumors, particularly those harboring prominent vasculature.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380302866849551891","@type":"Researcher","foaf:name":[{"@value":"Kotaro Uemura"}],"jpcoar:affiliationName":[{"@value":"Diagnostic Pathology"},{"@value":"Pediatric Surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1380302866849551894","@type":"Researcher","foaf:name":[{"@value":"Masato Komatsu"}],"jpcoar:affiliationName":[{"@value":"Diagnostic Pathology"}]},{"@id":"https://cir.nii.ac.jp/crid/1380302866849551884","@type":"Researcher","foaf:name":[{"@value":"Shigeo Hara"}],"jpcoar:affiliationName":[{"@value":"Department of Diagnostic Pathology, Kobe City Medical Center General Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1380302866849551880","@type":"Researcher","foaf:name":[{"@value":"Teruya Kawamoto"}],"jpcoar:affiliationName":[{"@value":"Orthopedic Surgery"},{"@value":"Division of Orthopedic Surgery, Kobe University International Clinical Cancer Research Center, Kobe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380302866849551873","@type":"Researcher","foaf:name":[{"@value":"Yuko Bitoh"}],"jpcoar:affiliationName":[{"@value":"Pediatric Surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1380302866849551881","@type":"Researcher","foaf:name":[{"@value":"Tomoo Itoh"}],"jpcoar:affiliationName":[{"@value":"Diagnostic Pathology"}]},{"@id":"https://cir.nii.ac.jp/crid/1380302866849551883","@type":"Researcher","foaf:name":[{"@value":"Takanori Hirose"}],"jpcoar:affiliationName":[{"@value":"Division of Pathology for Regional Communication, Kobe University Graduate School of Medicine"},{"@value":"Department of Diagnostic Pathology, Hyogo Cancer Center, Akashi, Hyogo Prefecture, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01475185"}],"prism:publicationName":[{"@value":"American Journal of Surgical Pathology"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2023-03-06","prism:volume":"47","prism:number":"5","prism:startingPage":"547","prism:endingPage":"557"},"reviewed":"false","url":[{"@id":"https://journals.lww.com/10.1097/PAS.0000000000002029"}],"createdAt":"2023-03-06","modifiedAt":"2025-06-08","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Head%20and%20Neck%20Neoplasms","dc:title":"Head and Neck Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Fibrosarcoma","dc:title":"Fibrosarcoma"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms,%20Fibrous%20Tissue","dc:title":"Neoplasms, Fibrous Tissue"},{"@id":"https://cir.nii.ac.jp/all?q=Cytochrome%20P-450%20CYP1A1","dc:title":"Cytochrome P-450 CYP1A1"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Soft%20Tissue%20Neoplasms","dc:title":"Soft Tissue Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Angiofibroma","dc:title":"Angiofibroma"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040569382209297664","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"21K09250"},{"@type":"JGN","@value":"JP21K09250"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K09250/"}],"notation":[{"@language":"ja","@value":"人工骨肉腫幹細胞を用いた骨肉腫新規治療の開発"},{"@language":"en","@value":"Development of new treatment strategies for osteosarcoma using induced osteosarcoma stem cells"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004235526593920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Histological spectrum of angiofibroma of soft tissue: histological and genetic analysis of 13 cases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142655093376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NKX3-1 Is a Useful Immunohistochemical Marker of EWSR1-NFATC2 Sarcoma and Mesenchymal Chondrosarcoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021396528740096","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Quantitative proteomics identifies biomarkers to distinguish pulmonary from head and neck squamous cell carcinomas by immunohistochemistry"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692742140928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"NKX2.2 is a Useful Immunohistochemical Marker for Ewing Sarcoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302867635380608","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360302868286519680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Detrimental activation of AhR pathway in cancer: an overview of therapeutic strategies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185768405120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Angiofibroma of soft tissue with fibrohistiocytic features and intratumor genetic heterogeneity of <scp><i>NCOA2</i></scp> gene rearrangement revealed by chromogenic <i>in situ</i> hybridization: A case report"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584346098855168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gene fusions AHRR-NCOA2, NCOA2-ETV4, ETV4-AHRR, P4HA2-TBCK, and TBCK-P4HA2 resulting from the translocations t(5;8;17)(p15;q13;q21) and t(4;5)(q24;q31) in a soft tissue angiofibroma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855569158462592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Diagnostic utility of NCOA2 fluorescence in situ hybridization and Stat6 immunohistochemistry staining for soft tissue angiofibroma and morphologically similar fibrovascular tumors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865818720648576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Soft tissue angiofibroma: Clinicopathologic, immunohistochemical and molecular analysis of 14 cases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360866223603894144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Biosynthesis Of All-trans-Retinoic Acid from All-trans-Retinol: Catalysis of All-trans-Retinol Oxidation by Human P-450 Cytochromes"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418520729217664","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Arachidonic and eicosapentaenoic acid metabolism by human CYP1A1: highly stereoselective formation of 17(R),18(S)-epoxyeicosatetraenoic acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468392661888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Angiofibroma of Soft Tissue"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470969453312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"A novel <i>GTF2I/NCOA2</i> fusion gene emphasizes the role of <i>NCOA2</i> in soft tissue angiofibroma development"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946360095488","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MUC4 Is a Sensitive and Extremely Useful Marker for Sclerosing Epithelioid Fibrosarcoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544421409184512","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Fusion of the <i>AHRR</i> and <i>NCOA2</i> genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896269935872","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"RBM10-TFE3 Renal Cell Carcinoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388843392124416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"MUC4 Is a Highly Sensitive and Specific Marker for Low-grade Fibromyxoid Sarcoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845826538752","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Regulation of constitutive and inducible AHR signaling: Complex interactions involving the AHR repressor"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318625272704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Characterization of the Oxidative Metabolites of 17β-Estradiol and Estrone Formed by 15 Selectively Expressed Human Cytochrome P450 Isoforms"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1097/pas.0000000000002029"},{"@type":"KAKEN","@value":"PRODUCT-25025914"},{"@type":"OPENAIRE","@value":"doi_dedup___::71f410f76499b8c5eadd6abea0a12f32"}]}