{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360306905187563008.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/biom14091126"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/2218-273X/14/9/1126/pdf"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Modeling Epithelial Homeostasis and Perturbation in Three-Dimensional Human Esophageal Organoids"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Background: Esophageal organoids from a variety of pathologies including cancer are grown in Advanced Dulbecco’s Modified Eagle Medium-Nutrient Mixture F12 (hereafter ADF). However, the currently available ADF-based formulations are suboptimal for normal human esophageal organoids, limiting the ability to compare normal esophageal organoids with those representing a given disease state. Methods: We have utilized immortalized normal human esophageal epithelial cell (keratinocyte) lines EPC1 and EPC2 and endoscopic normal esophageal biopsies to generate three-dimensional (3D) organoids. To optimize the ADF-based medium, we evaluated the requirement of exogenous epidermal growth factor (EGF) and inhibition of transforming growth factor-(TGF)-β receptor-mediated signaling, both key regulators of the proliferation of human esophageal keratinocytes. We have modeled human esophageal epithelial pathology by stimulating esophageal 3D organoids with interleukin (IL)-13, an inflammatory cytokine, or UAB30, a novel pharmacological activator of retinoic acid signaling. Results: The formation of normal human esophageal 3D organoids was limited by excessive EGF and intrinsic TGFβ-receptor-mediated signaling. Optimized HOME0 improved normal human esophageal organoid formation. In the HOME0-grown organoids, IL-13 and UAB30 induced epithelial changes reminiscent of basal cell hyperplasia, a common histopathologic feature in broad esophageal disease conditions including eosinophilic esophagitis. Conclusions: HOME0 allows modeling of the homeostatic differentiation gradient and perturbation of the human esophageal epithelium while permitting a comparison of organoids from mice and other organs grown in ADF-based media.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380306905187562916","@type":"Researcher","foaf:name":[{"@value":"Masataka Shimonosono"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187563016","@type":"Researcher","foaf:name":[{"@value":"Masaki Morimoto"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187563008","@type":"Researcher","foaf:name":[{"@value":"Wataru Hirose"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187562899","@type":"Researcher","foaf:name":[{"@value":"Yasuto Tomita"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187563028","@type":"Researcher","foaf:name":[{"@value":"Norihiro Matsuura"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187562890","@type":"Researcher","foaf:name":[{"@value":"Samuel Flashner"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187562905","@type":"Researcher","foaf:name":[{"@value":"Mesra S. Ebadi"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187563022","@type":"Researcher","foaf:name":[{"@value":"Emilea H. Okayasu"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187562910","@type":"Researcher","foaf:name":[{"@value":"Christian Y. Lee"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187562911","@type":"Researcher","foaf:name":[{"@value":"William R. Britton"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187562915","@type":"Researcher","foaf:name":[{"@value":"Cecilia Martin"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"},{"@value":"Organoid & Cell Culture Core, Columbia University Digestive and Liver Diseases Research Center, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187563029","@type":"Researcher","foaf:name":[{"@value":"Beverly R. Wuertz"}],"jpcoar:affiliationName":[{"@value":"Department of Otolaryngology, Head and Neck Surgery, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187562885","@type":"Researcher","foaf:name":[{"@value":"Anuraag S. Parikh"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"},{"@value":"Department of Otolaryngology, Head and Neck Surgery, Columbia University, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187563027","@type":"Researcher","foaf:name":[{"@value":"Uma M. Sachdeva"}],"jpcoar:affiliationName":[{"@value":"Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187562914","@type":"Researcher","foaf:name":[{"@value":"Frank G. Ondrey"}],"jpcoar:affiliationName":[{"@value":"Department of Otolaryngology, Head and Neck Surgery, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187563010","@type":"Researcher","foaf:name":[{"@value":"Venkatram R. Atigadda"}],"jpcoar:affiliationName":[{"@value":"Department of Dermatology, University of Alabama, Birmingham, AL 35294, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187563023","@type":"Researcher","foaf:name":[{"@value":"Craig A. Elmets"}],"jpcoar:affiliationName":[{"@value":"Department of Dermatology, University of Alabama, Birmingham, AL 35294, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187562900","@type":"Researcher","foaf:name":[{"@value":"Julian A. Abrams"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"},{"@value":"Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187562912","@type":"Researcher","foaf:name":[{"@value":"Amanda B. Muir"}],"jpcoar:affiliationName":[{"@value":"Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children’s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187563018","@type":"Researcher","foaf:name":[{"@value":"Andres J. Klein-Szanto"}],"jpcoar:affiliationName":[{"@value":"Histopathology Facility, Fox Chase Cancer Center, Philadelphia, PA 19111, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187562896","@type":"Researcher","foaf:name":[{"@value":"Kenneth I. Weinberg"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics, Maternal & Child Health Research Institute, Stanford Cancer Institute, Stanford University, Stanford, CA 94305, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187563043","@type":"Researcher","foaf:name":[{"@value":"Fatemeh Momen-Heravi"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"},{"@value":"Cancer Biology and Immunology Laboratory, College of Dental Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306905187563041","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Nakagawa"}],"jpcoar:affiliationName":[{"@value":"Herbert Irving Comprehensive Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA"},{"@value":"Organoid & Cell Culture Core, Columbia University Digestive and Liver Diseases 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