{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360564064056983680.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/hr.2014.117"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/hr2014117.pdf"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/hr2014117"}},{"identifier":{"@type":"PMID","@value":"25185833"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Slight increase in urinary albumin excretion within the normal range predicts incident hypertension in a community-based Japanese population: the Takahata study"}],"description":[{"notation":[{"@value":"Recent studies have suggested that urine albumin excretion in the high normal range predicts hypertension. However, the relationship between urinary albumin excretion in spot urine and incident hypertension remains unclear in the general Japanese population. To clarify this relationship, we conducted a cohort study in a community-based population of 412 normotensive individuals without diabetes and renal insufficiency and examined the incidence of hypertension using the urinary albumin-to-creatinine ratio (UACR) at baseline. Incident hypertension was defined as new-onset systolic blood pressure ⩾ 140 mm Hg and/or diastolic blood pressure ⩾ 90 mm Hg and/or the use of anti-hypertensive drugs. During the follow-up period (median, 6.7 years), 133 subjects (32.3%) newly developed hypertension. The incidence of hypertension increased with an increase in baseline UACR (20.4% for UACR5 mg g(-1), 34.0% for 5-9.9 mg g(-1) UACR and 40.4% for 10-29.9 mg g(-1), P=0.002). Multivariate logistic regression analysis, after adjustment for possible confounders, showed that UACR 5-9.9 mg g(-1) and 10-29.9 mg g(-1) were independent risks for incident hypertension compared with UACR5 mg g(-1) (odds ratio (OR) 2.15, 95% confidence interval (CI) 1.16-4.10 and OR 2.67, 95% CI 1.36-5.38, respectively). Subgroup analysis revealed that subjects with increased UACR (⩾ 5 mg g(-1)) had a higher risk of incident hypertension than did those with low UACR (5 mg g(-1)), irrespective of their backgrounds (age, sex, smoking, alcohol consumption, obesity and urinary sodium excretion). In conclusion, this study showed that a slight increase in urinary albumin excretion might predict incident hypertension in a community-based Japanese population."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380285708382999558","@type":"Researcher","foaf:name":[{"@value":"Atsushi 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Revised equations for estimated GFR from serum creatinine in Japan"},{"@value":"Revised equations for estimated GFR from serum creatinine in Japan. American journal of kidney diseases: the official journal of the"},{"@value":"Revised equations for estimating glomerular filtration rate (GFR) from serum creatinine in Japan"},{"@value":"Hishida A; Collaborators developing the Japanese equation for estimated GFR. Revised equations for estimated GFR from serum creatinine in Japan"},{"@value":"Revised equation for estimated GFR from serum creatinine in Japan"},{"@value":"Collaborators developing the Japanese equation for estimating GFR. Revised equation for estimated GFR from serum creatinine in Japan"},{"@value":"Collaborators developing the Japanese equation for estimated GFR"},{"@value":"Japanese equation for estimated GFR"},{"@value":"Revised equation for estimating glomerular filtration rate (GFR) from serum creatinin in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/2050870367073829888","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Endothelial dysfunction as an underlying pathophysiological condition of chronic kidney disease"}]},{"@id":"https://cir.nii.ac.jp/crid/2051996266980979584","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Albuminuria is an independent predictor of all-cause and cardiovascular mortality in the Japanese population : the Takahata study"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/hr.2014.117"},{"@type":"KAKEN","@value":"PRODUCT-15264180"},{"@type":"KAKEN","@value":"PRODUCT-20629729"},{"@type":"OPENAIRE","@value":"doi_dedup___::2285b4fd0342c1e17ff47c0d1d9b493c"},{"@type":"CROSSREF","@value":"10.1038/hr.2017.74_references_DOI_J3EVfKfdPRyMdAI3aZiD6yrS3KT"},{"@type":"CROSSREF","@value":"10.1038/s41440-018-0036-2_references_DOI_J3EVfKfdPRyMdAI3aZiD6yrS3KT"},{"@type":"CROSSREF","@value":"10.1038/hr.2014.135_references_DOI_J3EVfKfdPRyMdAI3aZiD6yrS3KT"}]}