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The mammalian target of rapamycin (mTOR) cascade is one of the important pathways regulating cyst growth in ADPKD. Branched-chain amino acids (BCAAs), including leucine, play a crucial role to activate mTOR pathway. Therefore, we administered BCAA dissolved in the drinking water to Pkd1"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380847869163120771","@type":"Researcher","foaf:name":[{"@value":"Junya 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System"},{"@id":"https://cir.nii.ac.jp/all?q=TOR%20Serine-Threonine%20Kinases","dc:title":"TOR Serine-Threonine Kinases"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Polycystic%20Kidney,%20Autosomal%20Dominant","dc:title":"Polycystic Kidney, Autosomal Dominant"},{"@id":"https://cir.nii.ac.jp/all?q=Amino%20Acids,%20Branched-Chain","dc:title":"Amino Acids, Branched-Chain"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256945286784","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"17K09679"},{"@type":"JGN","@value":"JP17K09679"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K09679/"}],"notation":[{"@language":"ja","@value":"多発性嚢胞腎における嚢胞増悪の機序、および予後予測因子の解明"},{"@language":"en","@value":"Analysis of a factor and mechanism of cyst 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