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The present study first examined the uptake behavior of TiO(2) NPs modified with pre-S1/S2 (model protein-recognizing hepatocytes) by HepG2 cells for 24h. It took 6h for sufficient uptake of the TiO(2) NPs by the cells. Next, the effect of the TiO(2)/US treatment on HepG2 cell growth was examined for 96 h after the 1 MHz ultrasound was irradiated (0.1 W/cm(2), 30s) to the cells which incorporated the TiO(2) NPs. Apoptosis was observed at 6h after the TiO(2)/US treatment. Although no apparent cell-injury was observed until 24h after the treatment, the viable cell concentration had deteriorated to 46% of the control at 96 h. Finally, the TiO(2)/US treatment was applied to a mouse xenograft model. The pre-S1/S2-immobilized TiO(2) (0.1mg) was directly injected into tumors, followed by 1 MHz ultrasound irradiation at 1.0 W/cm(2) for 60s. As a result of the treatment repeated five times within 13 days, tumor growth could be hampered up to 28 days compared with the control 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Therapy"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Nude","dc:title":"Mice, Nude"},{"@id":"https://cir.nii.ac.jp/all?q=Proteins","dc:title":"Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Hep%20G2%20Cells","dc:title":"Hep G2 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasms,%20Experimental","dc:title":"Neoplasms, Experimental"},{"@id":"https://cir.nii.ac.jp/all?q=Radiation%20Dosage","dc:title":"Radiation Dosage"},{"@id":"https://cir.nii.ac.jp/all?q=High-Energy%20Shock%20Waves","dc:title":"High-Energy Shock Waves"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Sonication","dc:title":"Sonication"},{"@id":"https://cir.nii.ac.jp/all?q=Drug%20Delivery%20Systems","dc:title":"Drug Delivery Systems"},{"@id":"https://cir.nii.ac.jp/all?q=Treatment%20Outcome","dc:title":"Treatment Outcome"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282257083709568","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"22300177"},{"@type":"JGN","@value":"JP22300177"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300177/"}],"notation":[{"@language":"ja","@value":"腫瘍集積型光触媒ナノ粒子の創製と超音波力学的がん治療"},{"@language":"en","@value":"Sonodynamic cancer therapy with tumor targeting TiO_2 nanoparticles."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050306506458534144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Sonodynamic therapy using water-dispersed TiO2-polyethylene glycol compound on glioma cells : Comparison of cytotoxic mechanism with photodynamic 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