{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360565166147920640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.virol.2015.03.010"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0042682215001464?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0042682215001464?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"25817401"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection"}],"description":[{"notation":[{"@value":"Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral disease that is endemic in China, Korea and Japan. No effective vaccine or specific treatment for SFTS is currently available. Here, we used a mouse model to examine the effects of ribavirin, site-1 protease inhibitor PF-429242, steroids, and combination of minocycline and ciprofloxacin (MC) on SFTS infection. The antiserum from a patient who recovered from SFTS was also examined for its effect on mice. Administration of antiserum completely protected mice against lethal infection with SFTSV. It could also protect mice from showing clinical signs of the disease due to non-lethal infection. MC-treatment resulted in prolonged survival times during lethal infection. Although other agents had no significant protective effects, they did not provide detrimental effects that could lead to progression of the disease in mice. Our results suggest that antiserum treatment may be clinically useful for post-exposure prophylaxis against SFTSV 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Viral"},{"@id":"https://cir.nii.ac.jp/all?q=Bunyaviridae%20Infections","dc:title":"Bunyaviridae Infections"},{"@id":"https://cir.nii.ac.jp/all?q=Severe%20fever%20with%20thrombocytopenia%20syndrome","dc:title":"Severe fever with thrombocytopenia syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=Post-exposure%20prophylaxis","dc:title":"Post-exposure prophylaxis"},{"@id":"https://cir.nii.ac.jp/all?q=Antiviral%20Agents","dc:title":"Antiviral Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Survival%20Analysis","dc:title":"Survival Analysis"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Mouse%20model","dc:title":"Mouse model"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Treatment%20Outcome","dc:title":"Treatment Outcome"},{"@id":"https://cir.nii.ac.jp/all?q=Virology","dc:title":"Virology"},{"@id":"https://cir.nii.ac.jp/all?q=Ribavirin","dc:title":"Ribavirin"},{"@id":"https://cir.nii.ac.jp/all?q=Human%20antiserum","dc:title":"Human antiserum"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Post-Exposure%20Prophylaxis","dc:title":"Post-Exposure Prophylaxis"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782247228416","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25304045"},{"@type":"JGN","@value":"JP25304045"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25304045/"}],"notation":[{"@language":"ja","@value":"インドシナ地域におけるマダニ媒介性人獣共通感染ウイルスの分布調査"},{"@language":"en","@value":"Epidemiological and experimental studies of Tick-borne viruses in Indochina"}]},{"@id":"https://cir.nii.ac.jp/crid/1040282257244181888","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"25660229"},{"@type":"JGN","@value":"JP25660229"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25660229/"}],"notation":[{"@language":"ja","@value":"フラビウイルス脳炎重症化機序のin vivo分子イメージング解析"},{"@language":"en","@value":"In vivo molecular imaging of viral encephalitis"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282812466493568","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tofla virus : A newly identified Nairovirus of the Crimean-Congo hemorrhagic fever group isolated from ticks in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1050850247228984576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Seroepidemiological evidence of severe fever with thrombocytopenia 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SPECT"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620127116672","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evaluation of the anti-arenaviral activity of the subtilisin kexin isozyme-1/site-1 protease inhibitor PF-429242"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905172943872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"N-glycosylation of viral glycoprotein is a novel determinant for the tropism and virulence of highly pathogenic tick-borne bunyaviruses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306906098995584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Two amino acid pairs in the Gc glycoprotein of severe fever with thrombocytopenia syndrome virus responsible for the enhanced 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