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Epidermal FABP (FABP5) Regulates Keratinocyte Differentiation by 13(S)-HODE-Mediated Activation of the NF-κB Signaling Pathway
Bibliographic Information
- Published
- 2011-03
- Resource Type
- journal article
- Rights Information
-
- https://www.elsevier.com/tdm/userlicense/1.0/
- https://www.elsevier.com/legal/tdmrep-license
- http://www.elsevier.com/open-access/userlicense/1.0/
- DOI
-
- 10.1038/jid.2010.342
- Publisher
- Elsevier BV
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Description
Fatty acid-binding proteins (FABPs) are postulated to serve as lipid shuttles that solubilize hydrophobic fatty acids and deliver them to appropriate intracellular sites. Epidermal FABP (E-FABP/FABP5) is predominantly expressed in keratinocytes and is overexpressed in the actively proliferating tissue characteristic of psoriasis and wound healing. In this study, we found decreased expression of the differentiation-specific proteins keratin 1, involucrin, and loricrin in E-FABP(-/-) keratinocytes relative to E-FABP(+/+) keratinocytes. We also determined that incorporation of linoleic acid was significantly reduced in E-FABP(-/-) keratinocytes. Although linoleic acid did not directly affect keratinocyte differentiation, keratin 1 expression was induced by the linoleic acid derivative 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE), and this induction was concomitant with increased NF-κB activity. In E-FABP(-/-) keratinocytes, the expression of 13(S)-HODE and the subsequent induction of NF-κB activity was lower than in wild-type keratinocytes. The reduction of linoleic acid in E-FABP(-/-) keratinocytes led to decreased cellular 13(S)-HODE content, resulting in decreased keratin 1 expression through downregulation of NF-κB activity. The regulation of fatty acid metabolism by E-FABP during keratinocyte differentiation suggests that E-FABP may have a role in the pathogenesis of psoriasis.
Journal
-
- Journal of Investigative Dermatology
-
Journal of Investigative Dermatology 131 (3), 604-612, 2011-03
Elsevier BV
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Keywords
- Keratinocytes
- Dermatology
- Fatty Acid-Binding Proteins
- Biochemistry
- Linoleic Acid
- Mice
- Animals
- Psoriasis
- Protein Precursors
- Molecular Biology
- Cells, Cultured
- Mice, Knockout
- Fatty Acids
- NF-kappa B
- Membrane Proteins
- Cell Differentiation
- Cell Biology
- Neoplasm Proteins
- Disease Models, Animal
- Linoleic Acids
- Epidermis
- Keratin-1
- Signal Transduction
Details 詳細情報について
-
- CRID
- 1360565166747570560
-
- ISSN
- 0022202X
-
- PubMed
- 21068754
-
- Article Type
- journal article
-
- Data Source
-
- Crossref
- KAKEN
- OpenAIRE
