{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1360565166756163712.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/ncomms13946"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/ncomms13946.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/ncomms13946"}},{"identifier":{"@type":"PMID","@value":"28067314"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Mutations of<jats:italic>DOCK8</jats:italic>in humans cause a combined immunodeficiency characterized by atopic dermatitis with high serum IgE levels. However, the molecular link between DOCK8 deficiency and atopic skin inflammation is unknown. Here we show that CD4<jats:sup>+</jats:sup>T cells from DOCK8-deficient mice produce large amounts of IL-31, a major pruritogen associated with atopic dermatitis. IL-31 induction critically depends on the transcription factor EPAS1, and its conditional deletion in CD4<jats:sup>+</jats:sup>T cells abrogates skin disease development in DOCK8-deficient mice. Although EPAS1 is known to form a complex with aryl hydrocarbon receptor nuclear translocator (ARNT) and control hypoxic responses, EPAS1-mediated<jats:italic>Il31</jats:italic>promoter activation is independent of ARNT, but in collaboration with SP1. On the other hand, we find that DOCK8 is an adaptor and negative regulator of nuclear translocation of EPAS1. Thus, EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction in CD4<jats:sup>+</jats:sup>T cells.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380566394945647104","@type":"Researcher","foaf:name":[{"@value":"Kazuhiko Yamamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751144184448","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"80532093"},{"@type":"NRID","@value":"1000080532093"},{"@type":"NRID","@value":"9000414242991"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/takehitouruno"}],"foaf:name":[{"@value":"Takehito Uruno"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394945647235","@type":"Researcher","foaf:name":[{"@value":"Akira Shiraishi"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326205054592","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00398083"},{"@type":"NRID","@value":"1000000398083"},{"@type":"NRID","@value":"9000288829995"},{"@type":"NRID","@value":"9000002633011"},{"@type":"NRID","@value":"9000018253137"},{"@type":"NRID","@value":"9000003808922"},{"@type":"NRID","@value":"9000003765824"},{"@type":"NRID","@value":"9000392072540"},{"@type":"NRID","@value":"9000305619137"},{"@type":"NRID","@value":"9000390875509"},{"@type":"NRID","@value":"9000021029202"},{"@type":"NRID","@value":"9000241873246"},{"@type":"NRID","@value":"9000018884445"},{"@type":"NRID","@value":"9000314080681"},{"@type":"NRID","@value":"9000254093685"},{"@type":"NRID","@value":"9000323840226"},{"@type":"NRID","@value":"9000257947330"},{"@type":"NRID","@value":"9000258302909"},{"@type":"NRID","@value":"9000011081466"},{"@type":"NRID","@value":"9000002333928"},{"@type":"NRID","@value":"9000337074789"},{"@type":"NRID","@value":"9000005707926"},{"@type":"NRID","@value":"9000288829832"},{"@type":"NRID","@value":"9000408889938"},{"@type":"NRID","@value":"9000388503991"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/tanakayo"}],"foaf:name":[{"@value":"Yoshihiko Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394945647361","@type":"Researcher","foaf:name":[{"@value":"Miho Ushijima"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394945647360","@type":"Researcher","foaf:name":[{"@value":"Takeshi Nakahara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394945647234","@type":"Researcher","foaf:name":[{"@value":"Mayuki Watanabe"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394945647236","@type":"Researcher","foaf:name":[{"@value":"Makiko Kido-Nakahara"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394945647107","@type":"Researcher","foaf:name":[{"@value":"Ikuya Tsuge"}]},{"@id":"https://cir.nii.ac.jp/crid/1380566394945647233","@type":"Researcher","foaf:name":[{"@value":"Masutaka Furue"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751141467264","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60243961"},{"@type":"NRID","@value":"1000060243961"},{"@type":"NRID","@value":"9000000337659"},{"@type":"NRID","@value":"9000239598238"},{"@type":"NRID","@value":"9000000376514"},{"@type":"NRID","@value":"9000333086480"},{"@type":"NRID","@value":"9000314079126"},{"@type":"NRID","@value":"9000411075615"},{"@type":"NRID","@value":"9000021233473"},{"@type":"NRID","@value":"9000018884446"},{"@type":"NRID","@value":"9000365002753"},{"@type":"NRID","@value":"9000021073063"},{"@type":"NRID","@value":"9000238914178"},{"@type":"NRID","@value":"9000238914174"},{"@type":"NRID","@value":"9000238912527"},{"@type":"NRID","@value":"9000414242996"},{"@type":"NRID","@value":"9000006850688"},{"@type":"NRID","@value":"9000323840227"},{"@type":"NRID","@value":"9000392112002"},{"@type":"NRID","@value":"9000242706787"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/1_1_1_1"}],"foaf:name":[{"@value":"Yoshinori Fukui"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20411723"}],"prism:publicationName":[{"@value":"Nature Communications"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2017-01-09","prism:volume":"8","prism:number":"1","prism:startingPage":"13946"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/ncomms13946.pdf"},{"@id":"https://www.nature.com/articles/ncomms13946"}],"createdAt":"2017-01-09","modifiedAt":"2023-08-21","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=CD4-Positive%20T-Lymphocytes","dc:title":"CD4-Positive T-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Heterozygote","dc:title":"Heterozygote"},{"@id":"https://cir.nii.ac.jp/all?q=Sp1%20Transcription%20Factor","dc:title":"Sp1 Transcription Factor"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Active%20Transport,%20Cell%20Nucleus","dc:title":"Active Transport, Cell Nucleus"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=Dermatitis,%20Atopic","dc:title":"Dermatitis, Atopic"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Cytosol","dc:title":"Cytosol"},{"@id":"https://cir.nii.ac.jp/all?q=Basic%20Helix-Loop-Helix%20Transcription%20Factors","dc:title":"Basic Helix-Loop-Helix Transcription 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medicine."}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050017057727081344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1050586963913289344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer’s Patches"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230267487872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Acute eosinophilic pneumonia occurring in a dedicator of cytokinesis 8 (DOCK8) deficient 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